Results 21 to 30 of about 3,653 (217)

Relationship between PPAR‐γ gene polymorphisms and ischemic stroke risk: A meta‐analysis

Brain and Behavior, Volume 11, Issue 12, December 2021., 2021
Ischemic strokes (IS) are one of the most common diseases resulting in disabilities and death among adults. Our meta‐analysis indicated that the individuals with G mutation of rs1801282 C/G polymorphism would face an increased risk of IS. But there was no significant association between rs3856806 C/T polymorphism and IS risk.
Fan Cheng, Xiao‐Min Si, Gong‐Li Yang, Lan Zhou   +3 more
wiley   +1 more source

Targeting the EZH2‐PPAR Axis Is a Potential Therapeutic Pathway for Pancreatic Cancer

PPAR Research, Volume 2021, Issue 1, 2021., 2021
Enhancer of zeste homolog 2 (EZH2) is abnormally highly expressed in pancreatic cancer (PC). However, it is not ideal to treat PC by inhibiting EZH2. This study reported that the combined use of pan‐peroxisome proliferator‐activated receptor (PPAR) agonist could significantly improve the anti‐PC effect of EZH2 inhibitor.
Jilong Hu, Zhinan Zheng, Jia Lei, Yuxin Cao, Qiyun Li, Zhi Zheng, Chuanjun Chen, Stéphane Mandard   +7 more
wiley   +1 more source

PPARα Gene Is Involved in Body Composition Variation in Response to an Aerobic Training Program in Overweight/Obese

PPAR Research, Volume 2021, Issue 1, 2021., 2021
The objective of this study was to investigate the relationship of the polymorphism in Intron 7 G/C (rs 4253778) of the peroxisome proliferator‐activated receptor alpha (PPARα) gene with the magnitude of changes in the body composition of an overweight and obese population that underwent an aerobic training program.
Glêbia A. Cardoso, Mateus D. Ribeiro, Bruno R. V. Sousa, Yohanna de Oliveira, Klécia F. Sena, Joane R. E. Batista, Antônio E. M. Almeida, João M. Filho, Raquel S. B. Silva, Darlene C. Persuhn, Alexandre S. Silva, Pascal Froment   +11 more
wiley   +1 more source

PPAR-γ Pro12Ala genotype and risk of cognitive decline in elders [PDF]

Neurobiology of Aging, 2008
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been associated with decreased risk of diabetes and obesity, both disorders linked to cognitive impairment. We tested whether this polymorphism is associated with cognition.Two thousand nine hundred sixty-one participants (mean age, 74.1; 41% Black; 52% women)
K, Yaffe, A M, Kanaya, K, Lindquist, W C, Hsueh, S R, Cummings, B, Beamer, A, Newman, C, Rosano, R, Li, T, Harris   +9 more
openaire   +2 more sources

Peroxisome proliferator-activated receptor-γ polymorphism (rs1801282) is associated with obesity in Egyptian patients with coronary artery disease and type 2 diabetes mellitus

Journal of Genetic Engineering and Biotechnology, 2017
Objective: Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) gene is one of the possible genes linking diabetes mellitus (DM) with coronary artery disease (CAD).
Nehal Salah Hasan, Solaf Ahmed Kamel, Mona Hamed, Eman Awadallah, Amany Hosny Abdel Rahman, Nevine Ibrahim Musa, Ghada Hussein Sayed Hussein   +6 more
doaj   +1 more source

The PPARγ2 P12A polymorphism is not associated with all-cause mortality in patients with type 2 diabetes mellitus [PDF]

, 2016
The high mortality risk of patients with type 2 diabetes mellitus may well be explained by the several comorbidities and/or complications. Also the intrinsic genetic component predisposing to diabetes might have a role in shaping the risk of diabetes ...
Alberico, Federica, Bacci, Simonetta, Cignarelli, Mauro, Copetti, Massimiliano, De Cosmo, Salvatore, Fontana, Andrea, Lamacchia, Olga, Marucci, Antonella, Mercuri, Luana, Pacilli, Antonio, Palena, Antonio, Prudente, Sabrina, Trischitta, Vincenzo, Viti, Raffaella   +13 more
core   +1 more source

A Possible Role for the PPARG Pro12Ala Polymorphism in Preterm Birth [PDF]

Diabetes, 2007
The links between preterm birth, low birth weight, and adult vascular/metabolic morbidity remain unclear. Genetic susceptibility of babies related to these three conditions might contribute to this long-term association. We tested whether the Pro12Ala polymorphism of the peroxisome proliferator–activated receptor γ (PPARG) gene could play a role in ...
Meirhaeghe, A, Boreham, CAG, Murray, LJ, Richard, F, Davey Smith, G, Young, IS, Amouyel, P   +6 more
openaire   +4 more sources

Investigation of peroxisome proliferator-activated receptor-gamma gene Pro12Ala polymorphism and its effect on peroxisome proliferator-activated receptor-gamma mRNA expression in human cancer cell lines

Medicine Science, 2019
The Peroxisome proliferator-activated receptor-gamma (PPARγ) is a member of the nuclear receptor family of transcription factors. In addition to its role in lipid and glucose metabolisms, PPARγ has possible roles in tumor suppression.
Hatice Kurnaz, Gunnur Demircan, Ayyub Ebrahimi, Hande Kocak   +3 more
doaj   +1 more source

Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine [PDF]

, 2019
Type 2 diabetes mellitus (T2DM) is a chronic disease that has reached the levels of a global epidemic. In order to achieve optimal glucose control, it is often necessary to rely on combination therapy of multiple drugs or insulin because uncontrolled ...
Andreozzi, F, Mannino, Gc, Sesti, G
core   +1 more source

FABP-2 and PPAR-γ Haplotype as Risk Factors for Dyslipidemia in a Type 2 Diabetes Mellitus Population of Santa Rosa del Conlara, San Luis, Argentina [PDF]

, 2014
Introduction: Type 2 Diabetes Mellitus (T2DM) is a complex disorder caused by the interaction between genetic predisposition and environmental factors. Genetics plays an important role on lipid homeostasis. Many genes are involved in the lipid metabolism,
Fernandez, Gustavo, Gonzalez, Irma Ines, Ojeda, Marta Susana, Olmos Nicotra, Maria Florencia, Siewert, Susana Elfrida   +4 more
core   +1 more source