Results 21 to 30 of about 1,172 (173)

Targeting the EZH2‐PPAR Axis Is a Potential Therapeutic Pathway for Pancreatic Cancer

PPAR Research, Volume 2021, Issue 1, 2021., 2021
Enhancer of zeste homolog 2 (EZH2) is abnormally highly expressed in pancreatic cancer (PC). However, it is not ideal to treat PC by inhibiting EZH2. This study reported that the combined use of pan‐peroxisome proliferator‐activated receptor (PPAR) agonist could significantly improve the anti‐PC effect of EZH2 inhibitor.
Jilong Hu, Zhinan Zheng, Jia Lei, Yuxin Cao, Qiyun Li, Zhi Zheng, Chuanjun Chen, Stéphane Mandard   +7 more
wiley   +1 more source

PPARα Gene Is Involved in Body Composition Variation in Response to an Aerobic Training Program in Overweight/Obese

PPAR Research, Volume 2021, Issue 1, 2021., 2021
The objective of this study was to investigate the relationship of the polymorphism in Intron 7 G/C (rs 4253778) of the peroxisome proliferator‐activated receptor alpha (PPARα) gene with the magnitude of changes in the body composition of an overweight and obese population that underwent an aerobic training program.
Glêbia A. Cardoso, Mateus D. Ribeiro, Bruno R. V. Sousa, Yohanna de Oliveira, Klécia F. Sena, Joane R. E. Batista, Antônio E. M. Almeida, João M. Filho, Raquel S. B. Silva, Darlene C. Persuhn, Alexandre S. Silva, Pascal Froment   +11 more
wiley   +1 more source

PPAR-γ Pro12Ala genotype and risk of cognitive decline in elders [PDF]

Neurobiology of Aging, 2008
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been associated with decreased risk of diabetes and obesity, both disorders linked to cognitive impairment. We tested whether this polymorphism is associated with cognition.Two thousand nine hundred sixty-one participants (mean age, 74.1; 41% Black; 52% women)
K, Yaffe, A M, Kanaya, K, Lindquist, W C, Hsueh, S R, Cummings, B, Beamer, A, Newman, C, Rosano, R, Li, T, Harris   +9 more
openaire   +2 more sources

Peroxisome proliferator-activated receptor-γ polymorphism (rs1801282) is associated with obesity in Egyptian patients with coronary artery disease and type 2 diabetes mellitus

Journal of Genetic Engineering and Biotechnology, 2017
Objective: Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) gene is one of the possible genes linking diabetes mellitus (DM) with coronary artery disease (CAD).
Nehal Salah Hasan, Solaf Ahmed Kamel, Mona Hamed, Eman Awadallah, Amany Hosny Abdel Rahman, Nevine Ibrahim Musa, Ghada Hussein Sayed Hussein   +6 more
doaj   +1 more source

Investigation of peroxisome proliferator-activated receptor-gamma gene Pro12Ala polymorphism and its effect on peroxisome proliferator-activated receptor-gamma mRNA expression in human cancer cell lines

Medicine Science, 2019
The Peroxisome proliferator-activated receptor-gamma (PPARγ) is a member of the nuclear receptor family of transcription factors. In addition to its role in lipid and glucose metabolisms, PPARγ has possible roles in tumor suppression.
Hatice Kurnaz, Gunnur Demircan, Ayyub Ebrahimi, Hande Kocak   +3 more
doaj   +1 more source

The PPAR  Pro12Ala polymorphism and risk for incident sporadic colorectal adenomas [PDF]

Carcinogenesis, 2004
Peroxisome proliferator-activated receptor gamma (PPARgamma), a member of the nuclear hormone receptor superfamily initially shown to be a key regulator of fat cell differentiation, can inhibit cell growth and induce apoptosis in colon cell lines.
Zhihong, Gong, Dawen, Xie, Zonglin, Deng, Roberd M, Bostick, Stephanie J, Muga, Thomas G, Hurley, James R, Hebert   +6 more
openaire   +2 more sources

Pro12Ala polymorphism in PPAR-γ2 and dementia in Chinese nonagenarians/centenarians [PDF]

AGE, 2010
We examined the existence of a relationship between polymorphism and dementia in subjects aged 90 years and above. The sample included 732 unrelated Chinese nonagenarians/centenarians (aged 90-108 years, mean age 93.68 years; 67.5% women). The Pro12Ala variant was examined using polymerase chain reaction restriction fragment length polymorphism ...
Ji-Rong, Yue, Bi-Rong, Dong, Chang-Quan, Huang, Zhen-Chan, Lu, Hong-Mei, Wu, Yan-Ling, Zhang   +5 more
openaire   +2 more sources

Peroxisome proliferator activated receptor gamma polymorphism Pro12Ala in polycystic ovary syndrome (PCOS) of South Indian Population

Asian Pacific Journal of Reproduction, 2016
Objective: To investigate the frequency of Pro12Ala polymorphism in PPAR gamma gene among PCOS of South Indian Population. Understanding this polymorphism may help us in better diagnosis prevention and therapeutic approaches towards management of PCOS ...
Raichel Jacob, Chandirasekar Ramachandran, Calistus Jude, Uthayakumar Venkatachalam, Sasikala Keshav Rao   +4 more
doaj   +1 more source

The association between serum resistin and PPARγ Pro12Ala polymorphism in patients with gestational diabetes mellitus

Pakistan Journal of Pharmaceutical Sciences, 2020
PPARγ Pro12Ala polymorphism is associated with the expression level of resistin and can induce insulin resistance. However, the possible effects of PPARγ Pro12Ala polymorphism for the origin of gestational diabetes mellitus are still unclear.
Yimin Yan, Xiaohong Yang, Tao Zhao, Yi Zou, Rui Li, Yancheng Xu   +5 more
doaj   +1 more source

The Pro12Ala polymorphism in the PPAR­γ2 gene is not associated with an increased risk of NAFLD in Iranian patients with type 2 diabetes mellitus

Cellular & Molecular Biology Letters, 2019
Background The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily.
Leila Saremi, Shirin Lotfipanah, Masumeh Mohammadi, Hassan Hosseinzadeh, Mina Fathi-Kazerooni, Behrooz Johari, Zohreh Saltanatpour   +6 more
doaj   +1 more source