Results 11 to 20 of about 3,653 (217)

Association between Pro12Ala polymorphism and albuminuria in type 2 diabetic nephropathy [PDF]

Journal of Diabetes Investigation, 2020
Aims/Introduction Diabetic nephropathy (DN) is a complication of diabetes mellitus that is characterized by the gradual loss of kidney function, which results in increased levels of albumin in the urine.
Yung‐Nien Chen, Pei‐Wen Wang, Shih‐Chen Tung, Ming‐Chun Kuo, Shao‐Wen Weng, Chen‐Kai Chou, Chih‐Min Chang, Chia‐Jen Tsa, Cheng‐Feng Taso, Feng‐Chih Shen, Jung‐Fu Chen   +10 more
doaj   +4 more sources

Polymorphism of Pro12Ala and C1431T PPARγin the pathogenesis of Graves' orbitopathy

Клиническая и экспериментальная тиреоидология, 2013
AIM: to examine the association of polymorphisms Pro12Ala and C1431T PPARγwith the development of thyroid eye disease (TEO). Materials and methods. A total of 88 people: 52 patients with TEO, 36 – healthy individuals.
D M Serkin, O V Serebryakova, M A Serkin, S V Charinzeva, N N Strambovskaya, S D Dagbaeva   +5 more
doaj   +3 more sources

PPAR𝛾2Pro12Ala Polymorphism and Human Health [PDF]

PPAR Research, 2009
The nuclear hormone receptor peroxisome proliferator activated receptor gamma (PPAR𝛾) is an important transcription factor regulating adipocyte differentiation, lipid and glucose homeostasis, and insulin sensitivity.
Weimin He
doaj   +2 more sources

Effects Of PPARγ2 Pro12Ala Variant On Adipocyte Phenotype Dependent Of DHA

Diabetes, Metabolic Syndrome and Obesity, 2019
Renhui Wan,* Zhengping Ding,* Sheng Xia, Longyi Zheng, Jin Lu Department of Endocrinology, Changhai Hospital, Second Military Medical University, Shanghai 200433, People’s Republic of China*These authors contributed equally to this ...
Wan R, Ding Z, Xia S, Zheng L, Lu J
doaj   +3 more sources

Molecular Dynamics Simulation and Essential Dynamics of Deleterious Proline 12 Alanine Single-Nucleotide Polymorphism in PPARγ2 Associated with Type 2 Diabetes, Cardiovascular Disease, and Nonalcoholic Fatty Liver Disease. [PDF]

PPAR Res, 2022
Background. Peroxisome proliferator‐activated receptor‐γ (PPARγ) gene is located at 3p25 position. PPARγ functions as the master regulator of glucose homeostasis and lipoprotein metabolism, and recent studies have reported that it is involved in various metabolic diseases such as diabetes mellitus, hyperlipidemia, coronary artery disease (CAD), and ...
Taghvaei S, Saremi L.
europepmc   +2 more sources

Implications of Genetic Elements on Type 2 Diabetes Mellitus Pathogenesis and Management. [PDF]

Endocrinol Diabetes Metab
Genetic variations in T2DM, including key metabolic and insulin‐related genes, influence disease risk, insulin resistance, and drug response. Understanding these polymorphisms enables precision medicine, optimising therapy and improving glycaemic control across diverse populations.
Ngcobo NN, Sibiya NH.
europepmc   +2 more sources

Pathophysiologic Mechanisms of Insulin Secretion and Signaling-Related Genes in Etiology of Polycystic Ovary Syndrome. [PDF]

Genet Res (Camb), 2021
Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women. PCOS is characterized by anovulation, hyperandrogenism, polycystic ovaries, insulin resistance, and obesity. Despite the finding that the genetic origin of PCOS is well demonstrated in previous twin and familial clustering studies, genes and factors that can exactly explain the PCOS ...
Shaaban Z, Khoradmehr A, Amiri-Yekta A, Nowzari F, Jafarzadeh Shirazi MR, Tamadon A.   +5 more
europepmc   +2 more sources

The Peroxisome Proliferator-Activated Receptor-γ2 Pro12Ala Polymorphism [PDF]

Diabetes, 2002
Peroxisome proliferator-activated receptor (PPAR)-γ is a transcription factor with a key role in adipocyte differentiation. The Ala allele of the common Pro12Ala polymorphism in the isoform PPAR-γ2 is associated with reduced risk for type 2 diabetes. The effect on the individual is weak, but because of a prevalence of >75% of the high-risk Pro ...
Michael, Stumvoll, Hans, Häring
openaire   +2 more sources

Effect of Pesticides on Peroxisome Proliferator‐Activated Receptors (PPARs) and Their Association with Obesity and Diabetes

PPAR Research, Volume 2023, Issue 1, 2023., 2023
Obesity and diabetes mellitus are considered the most important diseases of the XXI century. Recently, many epidemiological studies have linked exposure to pesticides to the development of obesity and type 2 diabetes mellitus. The role of pesticides and their possible influence on the development of these diseases was investigated by examining the ...
J. Hernández-Valdez, A. Velázquez-Zepeda, J. C. Sánchez-Meza, Stéphane Mandard   +3 more
wiley   +1 more source

The Peroxisome Poliferator–Activated Receptor-γ2 Pro12Ala Variant [PDF]

Diabetes, 2001
Recent studies have identified a common proline-to-alanine substitution (Pro12Ala) in the peroxisome proliferator–activated receptor-γ2 (PPAR-γ2), a nuclear receptor that regulates adipocyte differentiation and possibly insulin sensitivity. The Pro12Ala variant has been associated in some studies with diabetes-related traits and/or protection against ...
Julie A. Douglas, Michael R. Erdos, Richard M. Watanabe, Andi Braun, Cristy L. Johnston, Paul Oeth, Karen L. Mohlke, Timo T. Valle, Christian Ehnholm, Thomas A. Buchanan, Richard N. Bergman, Francis S. Collins, Michael Boehnke, Jaakko Tuomilehto   +13 more
openaire   +1 more source