Results 11 to 20 of about 1,172 (173)
PPAR-Gamma Pro12Ala Polymorphism and Gastric Cancer Risk in a Turkish Population
Asian Pacific Journal of Cancer Prevention, 2012 Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand dependent transcription factor involved in various processes, including carcinogenesis. We aimed to investigate any possible association of the PPARγPro12Ala (rs1801282) polymorphism with risk of developing gastric cancer (GC).A hospital based case control study was designed covering ...
Dursun Buḡra +2 more
exaly +5 more sources
PPARγ2 Pro12Ala Polymorphism is Associated in Children With Traits Related to Susceptibility to Type 2 Diabetes [PDF]
Frontiers in Pharmacology, 2021 Carmen Garces +2 more
exaly +2 more sources
Genel Tıp Dergisi, 2021 Amaç: Tip 2 diyabet (T2D), diyabetin en sık görülen türüdür ve tüm dünyada olduğu gibi ülkemizde de ciddi bir halk sağlığı sorunu haline gelmiştir. İnsülin sekresyonunun azalması ve/veya insülin direnci (İR) gelişimi, T2D patogenezinde yer alan iki ana ...
Süleyman Baldane +4 more
doaj +1 more source
The Peroxisome Proliferator-Activated Receptor-γ2 Pro12Ala Polymorphism [PDF]
Diabetes, 2002 Peroxisome proliferator-activated receptor (PPAR)-γ is a transcription factor with a key role in adipocyte differentiation. The Ala allele of the common Pro12Ala polymorphism in the isoform PPAR-γ2 is associated with reduced risk for type 2 diabetes. The effect on the individual is weak, but because of a prevalence of >75% of the high-risk Pro ...
Michael, Stumvoll, Hans, Häring
openaire +2 more sources
Genotype Phenotype Correlation of Genetic Polymorphism of PPAR Gamma Gene and Therapeutic Response to Pioglitazone in Type 2 Diabetes Mellitus-A Pilot Study [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Pro12Ala polymorphism is a missense mutation at codon 12 in peroxisome proliferator-activated receptor γ gene (PPARG). This polymorphism is known to be associated with increased insulin sensitivity. Pioglitazone, a thiazolidinedione, is
S. Shanmuga Priya +4 more
doaj +1 more source
PPAR Research, Volume 2023, Issue 1, 2023., 2023 Obesity and diabetes mellitus are considered the most important diseases of the XXI century. Recently, many epidemiological studies have linked exposure to pesticides to the development of obesity and type 2 diabetes mellitus. The role of pesticides and their possible influence on the development of these diseases was investigated by examining the ...
J. Hernández-Valdez +3 more
wiley +1 more source
Relationship between PPAR‐γ gene polymorphisms and ischemic stroke risk: A meta‐analysis
Brain and Behavior, Volume 11, Issue 12, December 2021., 2021 Ischemic strokes (IS) are one of the most common diseases resulting in disabilities and death among adults. Our meta‐analysis indicated that the individuals with G mutation of rs1801282 C/G polymorphism would face an increased risk of IS. But there was no significant association between rs3856806 C/T polymorphism and IS risk.
Fan Cheng +3 more
wiley +1 more source
The Pro12Ala PPARγ2 Variant Determines Metabolism at the Gene-Environment Interface [PDF]
Cell Metabolism, 2009 The metabolic impact of the common peroxisome proliferator-activated receptor gamma isoform 2 (PPARgamma2) variant Pro12Ala in human populations has been widely debated. We demonstrate, using a Pro12Ala knockin model, that on chow diet, Ala/Ala mice are leaner, have improved insulin sensitivity and plasma lipid profiles, and have longer lifespans. Gene-
Heikkinen, Sami +8 more
openaire +3 more sources
Pro12Ala substitution in the peroxisome proliferator-activated receptor gamma (PPARγ) gene and non-alcoholic fatty liver disease [PDF]
Archives of Biological Sciences, 2013 The aim of this study was to analyze the relationship between Pro12Ala substitution in the peroxisome proliferator-activated receptor gamma (PPARy) gene and non-alcoholic fatty liver disease (NAFLD).
Chen Shao-Hua +4 more
doaj +1 more source
A Possible Role for the PPARG Pro12Ala Polymorphism in Preterm Birth [PDF]
Diabetes, 2007 The links between preterm birth, low birth weight, and adult vascular/metabolic morbidity remain unclear. Genetic susceptibility of babies related to these three conditions might contribute to this long-term association. We tested whether the Pro12Ala polymorphism of the peroxisome proliferator–activated receptor γ (PPARG) gene could play a role in ...
Meirhaeghe, A +6 more
openaire +3 more sources