Results 31 to 40 of about 1,172 (173)

Association study of rs1801282 PPARG gene polymorphism and immune cells and cytokine levels in a Spanish pregnant women cohort and their offspring

Journal of Biomedical Science, 2020
Background Peroxisome proliferator activated receptor gamma (PPARG) belongs to the nuclear receptor superfamily functioning as transcription factors to regulate cellular differentiation, development and metabolism. Moreover, it has been implicated in the
Maria García-Ricobaraza, Mercedes García-Bermúdez, Francisco J. Torres-Espinola, M. Teresa Segura Moreno, Mathieu N. Bleyere, Ligia E. Díaz-Prieto, Esther Nova, Ascensión Marcos, Cristina Campoy   +8 more
doaj   +1 more source

Association of the PPARγ2 Pro12Ala polymorphism with increased risk of cardiovascular diseases

Genetics and Molecular Research, 2015
This meta-analysis investigated the correlation between the PPARγ2 Pro12Ala polymorphism and cardiovascular disease (CVD). Electronic database and manual searches were conducted to retrieve studies published relevant to the PPARγ2 Pro12Ala polymorphism and CVD.
Y, Li, J, Zhu, J Q, Ding
openaire   +2 more sources

The Peroxisome Poliferator–Activated Receptor-γ2 Pro12Ala Variant [PDF]

Diabetes, 2001
Recent studies have identified a common proline-to-alanine substitution (Pro12Ala) in the peroxisome proliferator–activated receptor-γ2 (PPAR-γ2), a nuclear receptor that regulates adipocyte differentiation and possibly insulin sensitivity. The Pro12Ala variant has been associated in some studies with diabetes-related traits and/or protection against ...
Julie A. Douglas, Michael R. Erdos, Richard M. Watanabe, Andi Braun, Cristy L. Johnston, Paul Oeth, Karen L. Mohlke, Timo T. Valle, Christian Ehnholm, Thomas A. Buchanan, Richard N. Bergman, Francis S. Collins, Michael Boehnke, Jaakko Tuomilehto   +13 more
openaire   +1 more source

The Frequency of Pro12Ala Genotypes of the PPARγ Gene in Diabetic and Non-Diabetic Patients with Polycystic Ovary Syndrome Referred to Imam Reza and Ghaem Hospitals, Mashhad, 2021 [PDF]

Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān
Introduction: The Pro12Ala polymorphism of the PPARγ gene affects insulin sensitivity, but its distribution in Iranian patients with polycystic ovary syndrome (PCOS) based on diabetic status has been less investigated.
Nafiseh Saghafi, Mahsa Khajoee, Tayebeh Hamzehloei   +2 more
doaj   +1 more source

The Association of PPARγ Pro12Ala and C161T Polymorphisms with Polycystic Ovary Syndrome and Their Influence on Lipid and Lipoprotein Profiles [PDF]

International Journal of Fertility and Sterility, 2018
Background The aim of present study was to clarify the role of the peroxisome proliferator-activated receptor (PPAR) γ Pro12Ala and C161T polymorphisms in the pathogenesis of polycystic ovary syndrome (PCOS) and their influence on lipid and ...
Zohreh Rahimi, Foroogh Chamaie-Nejad, Shohreh Saeidi, Ziba Rahimi, Ali Ebrahimi, Asad Vaisi-Raygani   +5 more
doaj   +1 more source

Obstructive sleep apnea and hypertriglyceridaemia share common genetic background: Results of a twin study

Journal of Sleep Research, Volume 29, Issue 4, August 2020., 2020
Abstract Obstructive sleep apnea is associated with an increased risk of hypertension, diabetes and dyslipidaemia. Both obstructive sleep apnea and its comorbidities are at least partly heritable, suggesting a common genetic background. Our aim was to analyse the heritability of the relationship between obstructive sleep apnea and its comorbidities ...
Martina Meszaros, Adam Domonkos Tarnoki, David Laszlo Tarnoki, Daniel Tamas Kovacs, Bianka Forgo, Jooyeon Lee, Joohon Sung, Jørgen Vestbo, Veronika Müller, Laszlo Kunos, Andras Bikov   +10 more
wiley   +1 more source

Does Pro12Ala Polymorphism Enhance the Physiological Role of PPARγ2?

PPAR Research, 2013
Obesity and type 2 diabetes mellitus (T2D) are two major public health problems that have motivated the scientific community to investigate the high contribution of genetic factors to these disorders.
A. C. Pereira, R. Oliveira, A. C. Castro, R. Fernandes   +3 more
doaj   +1 more source

The PPARG Pro12Ala Polymorphism and 20-year Cognitive Decline [PDF]

Alzheimer Disease & Associated Disorders, 2018
Previous reports suggest race/ethnic and sex heterogeneity in the association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma (PPARG) gene and cognitive decline. Tests of verbal memory, processing speed, and verbal fluency and a composite global Z-score were used to assess cognitive performance longitudinally ...
Nancy A, West, Jonathan V, Tingle, Jeannette, Simino, Elizabeth, Selvin, Jan, Bressler, Thomas H, Mosley   +5 more
openaire   +2 more sources

Investigation of the association of Pro12Ala polymorphism in the PPARG gene with the occurence of obesity and metabolic syndrome in postmenopausal women [PDF]

Medicinski Podmladak
Introduction: During menopause, the prevalence of metabolic disorders in women increases significantly. Postmenopausal women have increased waist circumference, high blood pressure, hypertriglyceridemia, hyperglycemia and low HDL cholesterol, which leads
Pucar Aleksandra, Milanović Ana, Maksimović Nela, Filipović Tamara   +3 more
doaj   +1 more source

Association of Peroxisome Proliferator‐Activated Receptors (PPARs) with Diabetic Retinopathy in Human and Animal Models: Analysis of the Literature and Genome Browsers

PPAR Research, Volume 2020, Issue 1, 2020., 2020
Diabetic retinopathy (DR) is a condition that develops after long‐lasting and poorly handled diabetes and is presently the main reason for blindness among elderly and youth. Peroxisome proliferator‐activated receptors (PPARs) are nuclear receptors that are involved in carbohydrate and fatty‐acid metabolism and have also been associated with DR.
Špela Tajnšek, Danijel Petrovič, Mojca Globočnik Petrovič, Tanja Kunej, John P. Vanden Heuvel   +4 more
wiley   +1 more source