Genome-wide scanning versus candidate gene approach in the genetic architecture of common diseases. [PDF]
, 2007 In the Nature 7 June issue, researchers from the Welcome Trust Case Control Consortium (WTCCC) reported the findings of a large genome-wide association (GWA) study of 14,000 cases of common diseases and 3000 controls studies revealing the role of several
Carlos J. Pirola, Silvia Sookoian
core +2 more sources
The PPAR Pro12Ala polymorphism and risk for incident sporadic colorectal adenomas [PDF]
Carcinogenesis, 2004 Peroxisome proliferator-activated receptor gamma (PPARgamma), a member of the nuclear hormone receptor superfamily initially shown to be a key regulator of fat cell differentiation, can inhibit cell growth and induce apoptosis in colon cell lines.
Zhihong, Gong +6 more
openaire +2 more sources
Genetic variants and the metabolic syndrome: a systematic review [PDF]
, 2011 Several candidate gene studies on the metabolic syndrome (MetS) have been conducted. However, for most single nucleotide polymorphisms (SNPs) no systematic review on their association with MetS exists.
Boer, J.M., Feskens, E.J.M., Povel, C.M.
core +3 more sources
Pro12Ala polymorphism in PPAR-γ2 and dementia in Chinese nonagenarians/centenarians [PDF]
AGE, 2010 We examined the existence of a relationship between polymorphism and dementia in subjects aged 90 years and above. The sample included 732 unrelated Chinese nonagenarians/centenarians (aged 90-108 years, mean age 93.68 years; 67.5% women). The Pro12Ala variant was examined using polymerase chain reaction restriction fragment length polymorphism ...
Ji-Rong, Yue +5 more
openaire +2 more sources
Asian Pacific Journal of Reproduction, 2016 Objective: To investigate the frequency of Pro12Ala polymorphism in PPAR gamma gene among PCOS of South Indian Population. Understanding this polymorphism may help us in better diagnosis prevention and therapeutic approaches towards management of PCOS ...
Raichel Jacob +4 more
doaj +1 more source
PPAR gamma Pro(12)Ala polymorphism and risk of acute coronary syndrome in a prospective study of Danes [PDF]
, 2009 Background: Acute coronary syndrome (ACS) is a major cause of morbidity and mortality in the western world. Peroxisome proliferator-activated receptor gamma (PPAR gamma) plays a key role in the regulation of the energy balance, adipocyte differentiation ...
Ulla Vogel +36 more
core +5 more sources
Cellular & Molecular Biology Letters, 2019 Background The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily.
Leila Saremi +6 more
doaj +1 more source
Interaction of genetic risk factors confers increased risk for metabolic syndrome: the role of peroxisome proliferator-activated receptor γ [PDF]
, 2014 AIM: The aim of the study was to estimate the influence of interactions between peroxisome proliferator-activated receptor γ (PPARγ) and target genes lipoprotein lipase (LPL), interleukin 6 (IL6), angiotensin converting enzyme (ACE), and angiotensin ...
Božina, Tamara +5 more
core +1 more source
Assessment of the Pro12Ala polymorphism in the PPAR-γ2 gene among type 2 diabetes patients in a Nigerian population [PDF]
, 2018 The association between the Pro12Ala polymorphism of the PPARγ2 gene, type 2 diabetes (T2D), and obesity in certain ethnic populations has been reported. However, this relationship has not yet been described among diabetes patients in Nigeria. This study
Chiezey, Venatus Osita +5 more
core +2 more sources
The Association of PPARγ Pro12Ala and C161T Polymorphisms with Polycystic Ovary Syndrome and Their Influence on Lipid and Lipoprotein Profiles [PDF]
International Journal of Fertility and Sterility, 2018 Background The aim of present study was to clarify the role of the peroxisome proliferator-activated receptor (PPAR) γ Pro12Ala and C161T polymorphisms in the pathogenesis of polycystic ovary syndrome (PCOS) and their influence on lipid and ...
Zohreh Rahimi +5 more
doaj +1 more source