Results 41 to 50 of about 3,653 (217)

Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa [PDF]

, 2014
Please cite as follows: Vergotine, Z. et al. 2014. Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from ...
Andre P Kengne, Rajiv T Erasmus, Tandi E Matsha, Yandiswa Y Yako, Zelda Vergotine   +4 more
core   +3 more sources

Obstructive sleep apnea and hypertriglyceridaemia share common genetic background: Results of a twin study

Journal of Sleep Research, Volume 29, Issue 4, August 2020., 2020
Abstract Obstructive sleep apnea is associated with an increased risk of hypertension, diabetes and dyslipidaemia. Both obstructive sleep apnea and its comorbidities are at least partly heritable, suggesting a common genetic background. Our aim was to analyse the heritability of the relationship between obstructive sleep apnea and its comorbidities ...
Martina Meszaros, Adam Domonkos Tarnoki, David Laszlo Tarnoki, Daniel Tamas Kovacs, Bianka Forgo, Jooyeon Lee, Joohon Sung, Jørgen Vestbo, Veronika Müller, Laszlo Kunos, Andras Bikov   +10 more
wiley   +1 more source

PPARγ2 Pro12Ala Polymorphism and Insulin Resistance in Japanese Hypertensive Patients

Hypertension Research, 2002
We investigated the relationship between peroxisome proliferator-activated receptor gamma (PPARgamma) Pro12Ala substitution and insulin resistance in subjects with normal insulin secretory capacity, since it has been reported that PPARgamma may affect not only insulin resistance but also insulin secretion.
Junko, Yamamoto, Shigeru, Kageyama, Masami, Nemoto, Takashi, Sasaki, Tatsuya, Sakurai, Ken-ichi, Ishibashi, Akira, Mimura, Kuninobu, Yokota, Naoko, Tajima   +8 more
openaire   +3 more sources

Investigation of the association of Pro12Ala polymorphism in the PPARG gene with the occurence of obesity and metabolic syndrome in postmenopausal women [PDF]

Medicinski Podmladak
Introduction: During menopause, the prevalence of metabolic disorders in women increases significantly. Postmenopausal women have increased waist circumference, high blood pressure, hypertriglyceridemia, hyperglycemia and low HDL cholesterol, which leads
Pucar Aleksandra, Milanović Ana, Maksimović Nela, Filipović Tamara   +3 more
doaj   +1 more source

Association of Peroxisome Proliferator‐Activated Receptors (PPARs) with Diabetic Retinopathy in Human and Animal Models: Analysis of the Literature and Genome Browsers

PPAR Research, Volume 2020, Issue 1, 2020., 2020
Diabetic retinopathy (DR) is a condition that develops after long‐lasting and poorly handled diabetes and is presently the main reason for blindness among elderly and youth. Peroxisome proliferator‐activated receptors (PPARs) are nuclear receptors that are involved in carbohydrate and fatty‐acid metabolism and have also been associated with DR.
Špela Tajnšek, Danijel Petrovič, Mojca Globočnik Petrovič, Tanja Kunej, John P. Vanden Heuvel   +4 more
wiley   +1 more source

Lifestyle factors modify obesity risk linked to PPARG2 and FTO variants in an elderly population: a cross-sectional analysis in the SUN Project. [PDF]

, 2012
Genetic factors may interact with lifestyle factors to modify obesity risk. FTO and PPARG2 are relevant obesogenes. Our aim was to explore the effect of Pro12Ala (rs1801282) of PPARG2 and rs9939609 of FTO on obesity risk and to examine their interaction ...
Galbete, C. (Cecilia), Guillen-Grima, F. (Francisco), Marti, A. (Amelia), Martinez, J.A. (José Alfredo), Martinez-Gonzalez, M.A. (Miguel Ángel), Toledo, J. (Jon)   +5 more
core   +1 more source

Does Pro12Ala Polymorphism Enhance the Physiological Role of PPARγ2?

PPAR Research, 2013
Obesity and type 2 diabetes mellitus (T2D) are two major public health problems that have motivated the scientific community to investigate the high contribution of genetic factors to these disorders.
A. C. Pereira, R. Oliveira, A. C. Castro, R. Fernandes   +3 more
doaj   +1 more source

ROLE OF THE PPARГ PROI2ALA POLYMORPHISM IN HYPERTENSION AND METABOLIC SYNDROME

Евразийский Кардиологический Журнал, 2012
Aim. То study prevalence of Pro12Ala polymorphism of the PPARγ gene in Uzbek hypertensive patients and healthy men and its association with blood pressure and cardiovascular remodeling process. Methods.
R. D. Kurbanov, N. Z. Srojidinova
doaj   +1 more source

The PPARγ2 Pro12Ala variant is protective against progression of nephropathy in people with type 2 diabetes [PDF]

, 2015
Cross-sectional studies suggest the association between diabetic nephropathy and the PPARγ2 Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 (PPARγ2).
BRUZZESE, DARIO, COCOZZA, SARA, COCOZZA, SERGIO, LAPICE, EMANUELA, Monticelli, Antonella, PINELLI, MICHELE, RICCARDI, GABRIELE, VACCARO, OLGA   +7 more
core   +1 more source

Qatari Genotype May Contribute to Complications in Type 2 Diabetes

Journal of Diabetes Research, Volume 2020, Issue 1, 2020., 2020
Objective. There is increasing evidence of a strong genetic component in type 2 diabetes (T2DM) that may contribute to diabetes complications. Given the high prevalence of diabetes with its associated complications in the Middle East, we sought to determine if the genotype within a Middle East population may be contributory.
Youssra Dakroury, Stephen L. Atkin, Soha R. Dargham, Amal Robay, Juan Rodriguez-Flores, Ronald G. Crystal, Alexandra E. Butler, Eusebio Chiefari   +7 more
wiley   +1 more source