Results 41 to 50 of about 1,172 (173)

ROLE OF THE PPARГ PROI2ALA POLYMORPHISM IN HYPERTENSION AND METABOLIC SYNDROME

Евразийский Кардиологический Журнал, 2012
Aim. То study prevalence of Pro12Ala polymorphism of the PPARγ gene in Uzbek hypertensive patients and healthy men and its association with blood pressure and cardiovascular remodeling process. Methods.
R. D. Kurbanov, N. Z. Srojidinova
doaj   +1 more source

Determinación del polimorfismo pro12ala en el receptor activado por proliferadores de peroxisomas gamma-2 en pacientes que padecen diabetes mellitus tipo 2

Tecnociencia
La diabetes mellitus es un grupo de trastornos metabólicos comunes que comparten el fenotipo de hiperglucemia. El polimorfismo Pro12Ala en el exón B del gen que codifica para PPARg2 ha sido asociado en algunas poblaciones con diabetes tipo 2.
Evelyn Visuete , Tomás A. Diez , Edgardo Castro, Magaly de Chial, Ana E. Tejada , Carlos W. Ramos D.   +5 more
doaj   +1 more source

PPARγ2 Pro12Ala Polymorphism and Insulin Resistance in Japanese Hypertensive Patients

Hypertension Research, 2002
We investigated the relationship between peroxisome proliferator-activated receptor gamma (PPARgamma) Pro12Ala substitution and insulin resistance in subjects with normal insulin secretory capacity, since it has been reported that PPARgamma may affect not only insulin resistance but also insulin secretion.
YAMAMOTO, Junko, KAGEYAMA, Shigeru, NEMOTO, Masami, SASAKI, Takashi, SAKURAI, Tatsuya, ISHIBASHI, Ken-ichi, MIMURA, Akira, YOKOTA, Kuninobu, TAJIMA, Naoko   +8 more
openaire   +3 more sources

UEG Week 2023 Moderated Posters

, 2023
United European Gastroenterology Journal, Volume 11, Issue S8, Page 201-534, October 2023.
wiley   +1 more source

The Pro12Ala polymorphism of the PPAR-γ gene is not associated with the polycystic ovary syndrome

Hormones, 2009
Insulin resistance is a key factor in the pathogenesis of polycystic ovary syndrome (PCOS). Peroxisome proliferator-activated- receptor-gamma (PPAR-gamma) has been implicated in insulin resistance and adiposity. The aim of the study was to investigate the possible involvement of the Pro12Ala polymorphism of the PPAR-gamma gene in the pathogenesis of ...
Xita, N., Lazaros, L., Georgiou, I., Tsatsoulis, A.   +3 more
openaire   +3 more sources

Mitigation of Metabolic Diseases Through Personalized Nutrition: A Critical In‐Depth Review

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
The main objective of this review is to explore the impact of variation within the microbiome and among genes on nutrient metabolism and argue in favor of successful evidence of individualized dietary intervention for cardiovascular disease, diabetes, and obesity.
Muhammad Tayyab Arshad, M. K. M. Ali, Farhang Hameed Awlqadr, Sammra Maqsood, Ali Ikram, Md. Sakhawot Hossain, Muhammed Adem Abdullahi, M. M. Rashed   +7 more
wiley   +1 more source

The common PPAR-γ2 Pro12Ala variant is associated with greater insulin sensitivity [PDF]

European Journal of Human Genetics, 2004
Several genetic variants of peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) have been identified, among which Pro12Ala, a missense mutation in exon 2, is highly prevalent in Caucasian populations. Up to now, conflicting results with regard to the association between this mutation and complex traits, such as obesity, insulin sensitivity ...
BUZZETTI, Raffaella, PETRONE, ANTONIO, M. C. Ribaudo, I. Alemanno, S. Zavarella, C. A. Mein, F. Maiani, TIBERTI, Claudio, BARONI, Marco Giorgio, VECCI, Elio Giancarlo, ARCA, Marcello, LEONETTI, Frida, DI MARIO, Umberto   +12 more
openaire   +2 more sources

Alcohol intake modulates the genetic association between HDL cholesterol and the PPARγ2 Pro12Ala polymorphism

Journal of Lipid Research, 2005
The peroxisome proliferator-activated receptor γ (PPARγ) Pro12Ala polymorphism affects plasma lipids, but to what extent alcohol intake interferes with this association remains unknown.
Stefan-Martin Brand-Herrmann, Tatiana Kuznetsova, Andreas Wiechert, Katarzyna Stolarz, Valerie Tikhonoff, Klaus Schmidt-Petersen, Ralph Telgmann, Edoardo Casiglia, Ji-Guang Wang, Lutgarde Thijs, Jan A. Staessen, Eva Brand   +11 more
doaj   +1 more source

Integrated Network Pharmacology Analysis and Experimental Validation of Zadi‐5 Against Coronary Heart Disease

Cardiology Research and Practice, Volume 2026, Issue 1, 2026.
This study aimed to investigate the potential molecular mechanisms underlying the therapeutic effects of the traditional Mongolian medicine Zadi‐5 on coronary heart disease (CHD). The active compounds of Zadi‐5 were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, and their corresponding targets ...
Jie Xiang, Jing Liu, Pengmei Liu, Esha Saini   +3 more
wiley   +1 more source

Association of the Human PPARY2 PRO12ALA Polymorphism with Obesity in a Population from Turkey [PDF]

Acta Endocrinologica (Bucharest), 2018
There have been a number of reports on the relationship between the PPARγ2 Pro12Ala genotype and the development of obesity.A case-control survey was designed to investigate the potential association between a Pro12Ala polymorphism in the PPARγ2 gene and obesity and/or obesity-related phenotypes in a population from Turkey.The polymerase chain reaction
Sozen, M. A., Ozcan, M. U., Cildir, M., Dogru, I. H., Aygok, A. G., Balkan, K. U.   +5 more
openaire   +2 more sources