Results 1 to 10 of about 76,534 (232)
Exploring PPAR Gamma and PPAR Alpha’s Regulation Role in Metabolism via Epigenetics Mechanism [PDF]
BiomoleculesPeroxisome proliferator-activated receptors (PPARs) belong to a family of nuclear receptors. To date, three types of PPARs, namely PPARα, PPARδ, and PPARγ, have been identified, demonstrating co-expression across numerous tissues.
Małgorzata Małodobra-Mazur +2 more
doaj +4 more sources
PPAR Gamma and Viral Infections of the Brain [PDF]
International Journal of Molecular Sciences, 2021 Peroxisome Proliferator-Activated Receptor gamma (PPARγ) is a master regulator of metabolism, adipogenesis, inflammation and cell cycle, and it has been extensively studied in the brain in relation to inflammation or neurodegeneration. Little is known however about its role in viral infections of the brain parenchyma, although they represent the most ...
Pierre Layrolle +2 more
exaly +7 more sources
Selective PPAR-Delta/PPAR-Gamma Activation Improves Cognition in a Model of Alzheimer’s Disease [PDF]
Cells, 2023 Background: The continuously increasing association of Alzheimer’s disease (AD) with increased mortality rates indicates an unmet medical need and the critical need for establishing novel molecular targets for therapeutic potential.
Ian Steinke +10 more
doaj +2 more sources
PPAR gamma pro12Ala polymorphism and type 2 diabetes: a study in a spanish cohort [PDF]
, 2014 Type 2 diabetes (T2D) is a disease whose occurrence is increasing prevalent in westernized civilizations and is responsible for the proliferation in the morbidity and total mortality of patients with cardiovascular diseases, worldwide.
Cieza Borrella, C +5 more
core +3 more sources
Prmt6 represses the pro-adipogenic Ppar-gamma–C/ebp-alpha transcription factor loop [PDF]
Scientific ReportsThe feed-forward loop between the transcription factors Ppar-gamma and C/ebp-alpha is critical for lineage commitment during adipocytic differentiation. Ppar-gamma interacts with epigenetic cofactors to activate C/ebp-alpha and the downstream adipocytic ...
Mirjam Gerstner +5 more
doaj +2 more sources
Frontiers in Physiology, 2014 Circadian clock mechanisms are far-from-equilibrium dissipative structures. Peroxisome proliferator-activated receptors (PPAR alpha, beta/delta and gamma) play a key role in metabolic regulatory processes, particularly in heart muscle.
Yves eLecarpentier +3 more
doaj +3 more sources
PPAR Gamma Receptor: A Novel Target to Improve Morbidity in Preterm Babies. [PDF]
Pharmaceuticals (Basel), 2023 Victor S +3 more
europepmc +3 more sources
Direct rosiglitazone action on steroidogenesis and proinflammatory factor production in human granulosa-lutein cells [PDF]
Reproductive Biology and Endocrinology, 2009 Background Ovarian granulosa cells are the predominant source of estradiol and progesterone biosynthesis in vivo. Rosiglitazone, a synthetic agonist of the peroxisome proliferator-activated receptor gamma (PPAR gamma), is applied as the treatment of ...
Wang Yongwei +6 more
doaj +3 more sources
Journal of Inflammation Research, 2021 Qiang Wang,* Hao Wang,* Qingxu Jing, Yang Yang, Dongbo Xue, Chenjun Hao, Weihui Zhang Department of General Surgery, Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin ...
Wang Q +6 more
doaj +1 more source
The Role of PPAR-gamma C161T Polymorphism in Colorectal Cancer Susceptibility. [PDF]
In Vivo, 2022 Kurnaz-Gomleksiz O +6 more
europepmc +3 more sources