Results 1 to 10 of about 43,248 (116)

Selective PPAR-Delta/PPAR-Gamma Activation Improves Cognition in a Model of Alzheimer’s Disease [PDF]

Cells, 2023
Background: The continuously increasing association of Alzheimer’s disease (AD) with increased mortality rates indicates an unmet medical need and the critical need for establishing novel molecular targets for therapeutic potential.
Ian Steinke, Manoj Govindarajulu, Priyanka Das Pinky, Jenna Bloemer, Sieun Yoo, Tracey Ward, Taylor Schaedig, Taylor Young, Fajar Setyo Wibowo, Vishnu Suppiramaniam, Rajesh H. Amin   +10 more
doaj   +2 more sources

Prmt6 represses the pro-adipogenic Ppar-gamma–C/ebp-alpha transcription factor loop [PDF]

Scientific Reports
The feed-forward loop between the transcription factors Ppar-gamma and C/ebp-alpha is critical for lineage commitment during adipocytic differentiation. Ppar-gamma interacts with epigenetic cofactors to activate C/ebp-alpha and the downstream adipocytic ...
Mirjam Gerstner, Vivien Heller, Johannes Fechner, Benedikt Hermann, Lei Wang, Joern Lausen   +5 more
doaj   +2 more sources

Exploring PPAR Gamma and PPAR Alpha’s Regulation Role in Metabolism via Epigenetics Mechanism [PDF]

Biomolecules
Peroxisome proliferator-activated receptors (PPARs) belong to a family of nuclear receptors. To date, three types of PPARs, namely PPARα, PPARδ, and PPARγ, have been identified, demonstrating co-expression across numerous tissues.
Małgorzata Małodobra-Mazur, Monika Ołdakowska, Tadeusz Dobosz   +2 more
doaj   +2 more sources

PPAR Gamma and Viral Infections of the Brain [PDF]

International Journal of Molecular Sciences, 2021
Pierre Layrolle, Pierre Payoux, Stephane Chavanas   +2 more
exaly   +2 more sources

Immunoregulatory actions of epithelial cell PPAR gamma at the colonic mucosa of mice with experimental inflammatory bowel disease. [PDF]

PLoS ONE, 2010
BACKGROUND: Peroxisome proliferator-activated receptors are nuclear receptors highly expressed in intestinal epithelial cells (IEC) and immune cells within the gut mucosa and are implicated in modulating inflammation and immune responses.
Saroj K Mohapatra, Amir J Guri, Montse Climent, Cristina Vives, Adria Carbo, William T Horne, Raquel Hontecillas, Josep Bassaganya-Riera   +7 more
doaj   +1 more source

PPAR gamma Agonists – Plant Compounds [PDF]

Journal of Stress Physiology & Biochemistry, 2023
The nuclear receptor peroxisome proliferator activated receptor-gamma (PPARg) controls adipocyte differentiation, as well as lipid metabolism and insulin sensitivity.
Anil Kumar Moola, Shobana G., C. Janani
doaj  

Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons

Cardiovascular Diabetology, 2005
There are three peroxisome proliferator-activated receptors (PPARs) subtypes which are commonly designated PPAR alpha, PPAR gamma and PPAR beta/delta.
Tenenbaum Alexander, Motro Michael, Fisman Enrique Z   +2 more
doaj   +1 more source

Alzheimer disease: crosstalk between the canonical Wnt/beta-catenin pathway and PPARs alpha and gamma

Frontiers in Neuroscience, 2016
The molecular mechanisms underlying the pathophysiology of Alzheimer's disease (AD) are still not fully understood. In AD, Wnt/beta-catenin signaling has been shown to be downregulated while the peroxisome proliferator-activated receptor (PPAR) gamma ...
Alexandre VALLEE, Yves Lecarpentier
doaj   +1 more source

Development of an In Vitro Screening Platform for the Identification of Partial PPARγ Agonists as a Source for Antidiabetic Lead Compounds

Molecules, 2018
Type 2 diabetes (T2D) is a metabolic disorder where insulin-sensitive tissues show reduced sensitivity towards insulin and a decreased glucose uptake (GU), which leads to hyperglycaemia.
Lars Porskjær Christensen, Rime Bahij El-Houri   +1 more
doaj   +1 more source

Circadian rhythms, Wnt/beta-catenin pathway and PPAR alpha/gamma profiles in diseases with primary or secondary cardiac dysfunction

Frontiers in Physiology, 2014
Circadian clock mechanisms are far-from-equilibrium dissipative structures. Peroxisome proliferator-activated receptors (PPAR alpha, beta/delta and gamma) play a key role in metabolic regulatory processes, particularly in heart muscle.
Yves eLecarpentier, Victor eClaes, Guillaume eDuthoit, Jean-Louis eHébert   +3 more
doaj   +1 more source