Results 1 to 10 of about 41,660 (152)
PPAR Gamma and Viral Infections of the Brain [PDF]
International Journal of Molecular Sciences, 2021 Peroxisome Proliferator-Activated Receptor gamma (PPARγ) is a master regulator of metabolism, adipogenesis, inflammation and cell cycle, and it has been extensively studied in the brain in relation to inflammation or neurodegeneration. Little is known however about its role in viral infections of the brain parenchyma, although they represent the most ...
Pierre Layrolle +2 more
exaly +7 more sources
Selective PPAR-Delta/PPAR-Gamma Activation Improves Cognition in a Model of Alzheimer’s Disease [PDF]
Cells, 2023 Background: The continuously increasing association of Alzheimer’s disease (AD) with increased mortality rates indicates an unmet medical need and the critical need for establishing novel molecular targets for therapeutic potential.
Ian Steinke +10 more
doaj +2 more sources
PPAR-gamma Fun(gi) With Prostaglandin. [PDF]
Nucl Recept Signal, 2020 In our recent publication, we show for the first time that the fungal pathogen Cryptococcus neoformans is able to manipulate host cells by producing eicosanoids that mimic those found in the host. Using complementary in vivo zebrafish and in vitro macrophage cell culture models of Cryptococcus infection, we found that these eicosanoids manipulate host
Evans RJ, Johnston SA.
europepmc +6 more sources
Prmt6 represses the pro-adipogenic Ppar-gamma–C/ebp-alpha transcription factor loop [PDF]
Scientific ReportsThe feed-forward loop between the transcription factors Ppar-gamma and C/ebp-alpha is critical for lineage commitment during adipocytic differentiation. Ppar-gamma interacts with epigenetic cofactors to activate C/ebp-alpha and the downstream adipocytic ...
Mirjam Gerstner +5 more
doaj +2 more sources
Studies on the contribution of PPAR Gamma to tuberculosis physiopathology. [PDF]
Front Cell Infect Microbiol, 2023 IntroductionTuberculosis (TB) is a major health problem characterized by an immuno-endocrine imbalance: elevated plasma levels of cortisol and pro- and anti-inflammatory mediators, as well as reduced levels of dehydroepiandrosterone. The etiological agent, Mycobacterium tuberculosis (Mtb), is captured by pulmonary macrophages (Mf), whose activation is ...
Díaz A +9 more
europepmc +5 more sources
Exploring PPAR Gamma and PPAR Alpha’s Regulation Role in Metabolism via Epigenetics Mechanism [PDF]
BiomoleculesPeroxisome proliferator-activated receptors (PPARs) belong to a family of nuclear receptors. To date, three types of PPARs, namely PPARα, PPARδ, and PPARγ, have been identified, demonstrating co-expression across numerous tissues.
Małgorzata Małodobra-Mazur +2 more
doaj +2 more sources
The Role of PPAR Gamma in Systemic Sclerosis [PDF]
PPAR Research, 2015 Fibrosis is recognized as an important feature of many chronic diseases, such as systemic sclerosis (SSc), an autoimmune disease of unknown etiology, characterized by immune dysregulation and vascular injury, followed by progressive fibrosis affecting ...
Andréa Tavares Dantas +7 more
doaj +3 more sources
Maintenance of Kidney Metabolic Homeostasis by PPAR Gamma. [PDF]
Int J Mol Sci, 2018 Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear hormone receptors that control the transcription of specific genes by binding to regulatory DNA sequences. Among the three subtypes of PPARs, PPARγ modulates a broad range of physiopathological processes, including lipid metabolism, insulin sensitization, cellular ...
Corrales P +2 more
europepmc +5 more sources
Clinical and Translational Medicine, 2017 Cancer cells are the site of numerous metabolic and thermodynamic abnormalities. We focus this review on the interactions between the canonical WNT/beta-catenin pathway and peroxisome proliferator-activated receptor gamma (PPAR gamma) in cancers and ...
Jean-Louis Hebert +2 more
exaly +3 more sources
PPAR Gamma and Angiogenesis: Endothelial Cells Perspective [PDF]
Journal of Diabetes Research, 2016 We summarize the current knowledge concerning PPARγ function in angiogenesis. We discuss the mechanisms of action for PPARγ and its role in vasculature development and homeostasis, focusing on endothelial cells, endothelial progenitor cells, and bone ...
Jerzy Kotlinowski, Alicja Jozkowicz
doaj +3 more sources