Results 41 to 50 of about 41,660 (152)
Regulation of the placental BCRP transporter by PPAR gamma [PDF]
Journal of Biochemical and Molecular Toxicology, 2016 AbstractIdentifying regulators of placental breast cancer resistance protein (BCRP) expression is critical as downregulation of this transporter may increase exposure of the fetus to xenobiotics. Here, we sought to test whether the nuclear receptor peroxisome proliferator‐activated receptor γ (PPARγ) regulates BCRP expression in the placenta.
Yixin, Lin +4 more
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Molecules, 2018 Xanthine-based KMUP-1 was shown to inhibit phosphodiesterases (PDEs) and modulate G-protein coupled receptors (GPCRs) to lower hyperlipidemia and body weight.
Chung-Pin Liu +6 more
doaj +1 more source
The target of arachidonic acid pathway is a new anticancer strategy for human prostate cancer
Biologics: Targets & Therapy, 2008 Masahide Matsuyama, Rikio YoshimuraDepartment of Urology, Osaka City University Graduate School of Medicine, Osaka, JapanAbstract: Recent epidemiological studies and animal experiments have demonstrated that nonsteroidal anti-inflammatory drugs (NSAIDs ...
Masahide Matsuyama, Rikio Yoshimura
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Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone
Drug Design, Development and Therapy, 2014 Xue-Jiao Wang,1 Jun Zhang,1 Shu-Qing Wang,1 Wei-Ren Xu,2 Xian-Chao Cheng,1 Run-Ling Wang1 1Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical ...
Wang XJ +5 more
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Drug Design, Development and Therapy, 2016 Yanzhe Wang, Zhiyi He, Shumin Deng Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, People’s Republic of China Background: Activators of PPARs, particularly PPARγ, may be effective ...
Wang Y, He Z, Deng S
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Reproductive Biology and Endocrinology, 2009 Background Ovarian granulosa cells are the predominant source of estradiol and progesterone biosynthesis in vivo. Rosiglitazone, a synthetic agonist of the peroxisome proliferator-activated receptor gamma (PPAR gamma), is applied as the treatment of ...
Wang Yongwei +6 more
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PPAR–gamma: a dagger in endometriosis
Australasian medical journal, 2010 Endometriosis is a debilitating gynecological disorder with an enigmatic pathogenesis. Current treatment strategy mainly involves surgery and medications, which provide only temporary relief. Endometriosis is associated with an abnormal inflammatory response, one of the recent pathogenesis is RANTES (regulated upon activation normal Tcell expressed and
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Drug Design, Development and Therapy, 2016 Ching-Han Lin,1,* Shang-Yu Lee,2,* Chun-Cheng Zhang,3 Ye-Fong Du,1 Hao-Chang Hung,1 Hung-Tsung Wu,4 Horng-Yih Ou1 1Department of Internal Medicine, Division of Endocrinology and Metabolism, National Cheng Kung University Hospital, College of Medicine ...
Lin CH +6 more
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Journal of Inflammation Research, 2021 Qiang Wang,* Hao Wang,* Qingxu Jing, Yang Yang, Dongbo Xue, Chenjun Hao, Weihui Zhang Department of General Surgery, Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin ...
Wang Q +6 more
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