Results 31 to 40 of about 43,347 (215)

Hierarchical Nanoplatform Integrating Oxidative–Acidic Microenvironment Remodeling and Bone Homeostasis Modulation for Diabetic Bone Defect Therapy

Advanced Science, EarlyView.
A hierarchical CM/LDH nanoplatform integrates ROS‐scavenging Ce‐MOF nanozymes with acid‐neutralizing CaAl‐LDH and is delivered within GelMA hydrogel to diabetic bone defects. By remodeling the oxidative‐acidic microenvironment, preserving mitochondrial homeostasis, and suppressing mtDNA–cGAS–STING inflammatory signaling, CM/LDH reduces proinflammatory ...
Xu Chen, Xingyu Zhu, Zhixin Qiu, Yijia Zhu, Xinhui Zheng, Dongqi Fan, Jinglei Zhan, Congxiu Mao, Ping Ji, Tao Chen, Qingqing He   +10 more
wiley   +1 more source

Emerging role of the peroxisome proliferator-activated receptor-gamma in hepatocellular carcinoma

Journal of Hepatocellular Carcinoma, 2014
Hui-Tzu Hsu,1 Chin-Wen Chi1,21Department and Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan; 2Department of Medical Research, Taipei Veterans General Hospital, Taipei, TaiwanAbstract: Hepatocellular carcinoma
Hsu HT, Chi CW
doaj  

Soy milk and ginger (Sulehe) increase PPAR-γ expression in a rat model of insulin resistance

Сахарный диабет, 2018
Background: Diabetes mellitus type 2 is metabolic disease characterized by hyperglycemia due to a defect in insulin secretion resulting in insulin resistance. This disease leads to dysfunction of various organs including eyes, kidneys, and heart.
Wiwik Handayani, Sri Andarini, Diana Lyrawati, Achmad Rudijanto   +3 more
doaj   +1 more source

Dual Compartmentalization of GSTA4 Suppresses Ferroptosis to Drive Antiandrogen Resistance in Prostate Cancer

Advanced Science, EarlyView.
The schematic diagram depicts a compartmentalized anti‐ferroptotic defense mechanism mediated by GSTA4. GSTA4 is upregulated and localizes to the cytoplasm in ENZR cells, where it detoxifies 4‐HNE via a non‐canonical GSH‐dependent pathway. Under oxidative stress, GSTA4 translocates to mitochondria, interacts with PGAM5, and blocks Drp1 Ser637 ...
Yong Luo, Wei Zhuang, Zean Li, Yiming Lai, Yongyi Ou, Dongquan Li, Shanhe Huang, Tianlong Luo, Jintao Hu, Bingliang Chen, Jianhan Fu, Tao Zhuo, Hankun Jiang, Yin Lu, Hai Huang, Kewei Xu, Shengmeng Peng, Qing Yuan   +17 more
wiley   +1 more source

Effects Of PPARγ2 Pro12Ala Variant On Adipocyte Phenotype Dependent Of DHA

Diabetes, Metabolic Syndrome and Obesity, 2019
Renhui Wan,* Zhengping Ding,* Sheng Xia, Longyi Zheng, Jin Lu Department of Endocrinology, Changhai Hospital, Second Military Medical University, Shanghai 200433, People’s Republic of China*These authors contributed equally to this ...
Wan R, Ding Z, Xia S, Zheng L, Lu J
doaj  

Thermodynamics in Gliomas: Interactions between the Canonical WNT/Beta-Catenin Pathway and PPAR Gamma

Frontiers in Physiology, 2017
Gliomas cells are the site of numerous metabolic and thermodynamics abnormalities with an increasing entropy rate which is characteristic of irreversible processes driven by changes in Gibbs energy, heat production, intracellular acidity, membrane ...
Alexandre Vallée, Alexandre Vallée, Yves Lecarpentier, Rémy Guillevin, Jean-Noël Vallée, Jean-Noël Vallée   +5 more
doaj   +1 more source

SLC25A4high Hepatocytes Enhance Lifestyle Intervention Response in MASLD by Recruiting Eating Macrophages

Advanced Science, EarlyView.
SLC25A4high hepatocytes drive metabolic‐associated steatotic liver disease (MASLD) remission by recruiting lipid‐eating macrophages. The hepatocyte Slc25a4/PANX1/ATP/P2ry12 axis mediates find‐me signaling that triggers macrophage recruitment and efferocytosis, while recruited macrophages secrete GDF15 to activate hepatocyte PPARα and promote fatty acid
Yiting Qian, Linying Lai, Yu Zhang, Yan Meng, Ziping Song, Baoyuan Huang, Guisheng Song, Bo Sun, Wenzhuo Yang   +8 more
wiley   +1 more source

Synergism in hyperhomocysteinemia and diabetes: role of PPAR gamma and tempol

Cardiovascular Diabetology, 2010
Background Hyperhomocysteinemia (HHcy) and hyperglycemia cause diabetic cardiomyopathy by inducing oxidative stress and attenuating peroxisome proliferator- activated receptor (PPAR) gamma. However, their synergistic contribution is not clear.
Mishra Paras K, Tyagi Neetu, Sen Utpal, Joshua Irving G, Tyagi Suresh C   +4 more
doaj   +1 more source

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source