Results 31 to 40 of about 76,534 (232)

Peroxisome proliferator-activated receptor alpha plays a crucial role in behavioral repetition and cognitive flexibility in mice [PDF]

, 2015
Acknowledgments We thank Luca Giordano, Giovanni Esposito and Angelo Russo for technical assistance and Dr. Livio Luongo (Second University of Naples–Italy) for critical discussions.
Avagliano, Carmen, Calignano, Antonio, Citraro, Rita, Cristiano, Claudia, D'Agostino, Giuseppe, De Sarro, Giovambattista, Heisler, Lora K, Lyons, David J, Meli, Rosaria, Raso, Giuseppina Mattace, Russo, Emilio, Russo, Roberto   +11 more
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PPAR gamma Pro(12)Ala polymorphism and risk of acute coronary syndrome in a prospective study of Danes [PDF]

, 2009
Background: Acute coronary syndrome (ACS) is a major cause of morbidity and mortality in the western world. Peroxisome proliferator-activated receptor gamma (PPAR gamma) plays a key role in the regulation of the energy balance, adipocyte differentiation ...
Ulla Vogel, Stine Segel, Claus Dethlefsen, Anne Tjønneland, Anne Thoustrup Saber, Håkan Wallin, Majken K Jensen, Erik B Schmidt, Paal Skytt Andersen, Kim Overvad, S Heikkinen, A Meirhaeghe, M Stumvoll, J Masugi, SS Deeb, A Tonjes, D Altshuler, AS Doney, PM Ridker, T Pischon, L Li, SM Brand-Herrmann, A Tjonneland, AM Joensen, MK Jensen, SA Miller, U Vogel, JD Kalbfleisch, U Vogel, MH Zafarmand, A Doney, AS Doney, U Vogel, MM Swarbrick, J Zhang, I Tegeder, U Vogel   +36 more
core   +5 more sources

Development of an In Vitro Screening Platform for the Identification of Partial PPARγ Agonists as a Source for Antidiabetic Lead Compounds

Molecules, 2018
Type 2 diabetes (T2D) is a metabolic disorder where insulin-sensitive tissues show reduced sensitivity towards insulin and a decreased glucose uptake (GU), which leads to hyperglycaemia.
Lars Porskjær Christensen, Rime Bahij El-Houri   +1 more
doaj   +1 more source

Tyrosine kinase inhibitors for the therapy of anaplastic thyroid cancer [PDF]

, 2015
Anaplastic thyroid cancer (ATC) is often incurable so new therapeutic approaches are needed. Tyrosine kinases inhibitors (such as imanitib, sunitinib or sorafenib) are under evaluation for the treatment of ATC.
Bond JA, Cohen EE, Dowlati A, Goulart B, Grande E, Hayashi N, Ibrahim N, Klopper JP, Mahlknecht U, Ohta K, Ruggeri RM, Sherman SI   +11 more
core   +1 more source

Peroxisome Proliferator-Activated Receptors and the Hallmarks of Cancer

Cells, 2022
Peroxisome proliferator-activated receptors (PPARs) function as nuclear transcription factors upon the binding of physiological or pharmacological ligands and heterodimerization with retinoic X receptors.
Nicole Wagner, Kay-Dietrich Wagner
doaj   +1 more source

Peroxisome Proliferator-Activated Receptor alpha (PPAR alpha) down-regulation in cystic fibrosis lymphocytes [PDF]

, 2006
Background: PPARs exhibit anti-inflammatory capacities and are potential modulators of the inflammatory response. We hypothesized that their expression and/or function may be altered in cystic fibrosis (CF), a disorder characterized by an excessive host ...
C Hubeau, RB Moss, P Reineck, AA Ionescu, LS Nixon, ME Poynter, P Delerive, SW Chung, BM Forman, W Wahli, JD Tugwood, JM Shipley, A Madej, JP Despres, N Marx, B Staels, Z Israelian-Konaraki, A Trifilieff, MA Birrell, M Roulet, PM Farrell, AP Sampson, JT Zakrzewski, J Carlstedt-Duke, SD Freedman, SM Loitsch, KA Kreuzer, JL Su, JD Dignam, TP Dean, K Balough, TZ Khan, A Augarten, F Akbiyik, I Inoue, DC Jones, P Greally, E Dagli, TA Waldmann, JH Parmentier, K Beier, C Andersson, M Ollero, H Pall, G Chinetti, PR Devchand, N Marx, AE Lovett-Racke, A Linden, F McAllister, RB Moss, RB Moss, C Hubeau, RU Sorensen   +53 more
core   +1 more source

Methanolic extract of Momordica cymbalaria enhances glucose uptake in L6 myotubes in vitro by up-regulating PPAR-gamma and GLUT-4 [PDF]

, 2014
The present study was undertaken to evaluate the influence of the methanolic fruit extract of Momordica cymbalaria (MFMC) on PPAR gamma (Peroxisome Proliferator Activated Receptor gamma) and GLUT-4 (Glucose transporter-4) with respect to glucose ...
Ashok, G., Kumar, P.M., Manjunath, K., Venkataranganna, M.V., Viswanatha, G.L.   +4 more
core   +1 more source

The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasomemediated degradation of PPAR gamma [PDF]

, 2018
Peroxisome proliferator-activated receptor gamma (PPAR??) is a ligand-dependent transcription factor that regulates adipocyte differentiation and glucose homeostasis. The transcriptional activity of PPAR??
A Must, A Orimo, A Reymond, BL Wagner, Byung-gyu Kim, CX Yuan, Dougu Nam, E Hu, ED Rosen, ED Rosen, ED Rosen, F Picard, G Consortium, G Heikel, G Kilroy, G Meroni, GD Girnun, GS Hotamisligil, H Oshiumi, J DiRenzo, J Kim, J Lonsdale, J Shi, Jae Min Lee, Jang Hyun Choi, JH Choi, JH Choi, JJ Li, JM Lehmann, K Ikeda, Keon Woo Khim, Kyungjae Myung, L Fajas, LA Walsh, M Watanabe, ME Trujillo, MU Gack, N Ouchi, N Sun, O Beekum, P Puigserver, P Rocca-Serra, P Tontonoz, P Tontonoz, Pann-Ghill Suh, R Keshet, S Choi, S Han, S Hauser, S Katsura, SC Kwon, Sora Yoon, SS Choi, Sun Sil Choi, T Lemberger, T Ohshima, UJ Jung, W Zou, X Qin, Y Sun, Y Xu, Yo Han Lee, Z Wu, ZE Floyd   +63 more
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Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer [PDF]

, 2016
Prostate cancer (CaP) is the most common adult male cancer in the developed world. The paucity of biomarkers to predict prostate tumor biology makes it important to identify key pathways that confer poor prognosis and guide potential targeted therapy ...
Adams, David J., Ahmad, Imran, Edwards, Joanne, Galbraith, Laura, Hedley, Ann, Leung, Hing Y., Loveridge, Carolyn, Markert, Elke, Mui, Ernest, Patel, Rachana, Repiscak, Peter, Rust, Alistair G., Salji, Mark, Sansom, Owen J., Tan, Ee Hong, van der Weyden, Louise   +15 more
core   +1 more source

The nuclear receptor PPARγ as a therapeutic target for cerebrovascular and brain dysfunction in Alzheimer's disease

Frontiers in Aging Neuroscience, 2010
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear transcription factors that regulate peripheral lipid and glucose metabolism. Three subtypes make up the PPAR family (α, γ, β/δ), and synthetic ligands
Nektaria Nicolakakis, Edith Hamel
doaj   +1 more source