The role of peroxisome proliferator-activated receptors in the tumor microenvironment, tumor cell metabolism, and anticancer therapy [PDF]
Frontiers in Pharmacology, 2023 Peroxisome proliferator-activated receptors (PPARs) have been extensively studied for over 3 decades and consist of three isotypes, including PPARα, γ, and β/δ, that were originally considered key metabolic regulators controlling energy homeostasis in ...
Jiaao Sun +3 more
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The Role of Peroxisome Proliferator-Activated Receptors in Preeclampsia [PDF]
Cells, 2023 Preeclampsia is a common pregnancy-related hypertensive disorder. Often presenting as preexisting or new-onset hypertension complicated by proteinuria and/or end-organ dysfunction, preeclampsia significantly correlates with maternal and perinatal ...
Iason Psilopatis +3 more
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Peroxisome Proliferator-Activated Receptors Regulate Hepatic Immunity and Assist in the Treatment of Primary Biliary Cholangitis [PDF]
Frontiers in Immunology, 2022 Fibrates, which are agonists of peroxisome proliferator-activated receptor alpha, have received increasing attention in the treatment of primary biliary cholangitis.
Chang Wang +12 more
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Peroxisome Proliferator-Activated Receptors and the Hallmarks of Cancer [PDF]
Cells, 2022 Peroxisome proliferator-activated receptors (PPARs) function as nuclear transcription factors upon the binding of physiological or pharmacological ligands and heterodimerization with retinoic X receptors.
Nicole Wagner, Kay-Dietrich Wagner
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Peroxisome Proliferator-Activated Receptors (PPARs): A Themed Issue in Honor of Prof. Walter Wahli [PDF]
BiomoleculesIt is with great pleasure that we introduce this Special Issue dedicated to Peroxisome Proliferator-Activated Receptors (PPARs), honoring the pioneering contributions of Professor Walter Wahli [...]
Hervé Guillou, Manuel Vázquez-Carrera
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The role of peroxisome proliferator-activated receptors in endometriosis [PDF]
Frontiers in MedicineEndometriosis constitutes the most common cause of chronic pelvic pain in female patients and is associated with infertility. Although there is no known cause for the disease, it is a heritable condition that is determined by numerous genetic, epigenetic,
Iason Psilopatis +2 more
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White adipose tissue browning and peroxisome proliferator activated receptors in MASLD [PDF]
Frontiers in EndocrinologyMetabolic dysfunction associated steatotic liver disease (MASLD) has emerged as the predominant global etiology of chronic liver disease, with its incidence and prevalence continuously rising amid the obesity epidemic. The human body contains two primary
Zexuan Li, Huikuan Chu, Ling Yang
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Marine Natural and Nature-Inspired Compounds Targeting Peroxisome Proliferator Activated Receptors (PPARs) [PDF]
Marine Drugs, 2023 Peroxisome proliferator-activated receptors α, γ and β/δ (PPARα, PPARγ, and PPARβ/δ) are a family of ligand-activated transcriptional factors belonging to the superfamily of nuclear receptors regulating the expression of genes involved in lipid and ...
Enrico D’Aniello +2 more
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Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy [PDF]
PPAR Research, 2008 Diabetic nephropathy is a leading cause of end-stage renal disease, which is increasing in incidence worldwide, despite intensive treatment approaches such as glycemic and blood pressure control in patients with diabetes mellitus.
Shinji Kume +3 more
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Peroxisome Proliferator-Activated Receptors and Shock State [PDF]
The Scientific World Journal, 2006 Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid, and thyroid hormone receptors.
Emanuela Esposito +2 more
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