Results 21 to 30 of about 1,310,860 (245)

Peroxisome proliferator-activated receptor agonists (PPARs): a promising prospect in the treatment of psoriasis and psoriatic arthritis [PDF]

Anais Brasileiros de Dermatologia, 2013
Psoriasis is a polygenic, inflammatory and progressive disease, characterized by an abnormal differentiation and hyperproliferation of keratinocytes, associated with impaired immunologic activation and systemic disorders, while psoriatic arthritis is a ...
Emerson de Andrade Lima, Mariana Modesto Dantas de Andrade Lima, Cláudia Diniz Lopes Marques, Angela Luzia Branco Pinto Duarte, Ivan da Rocha Pita, Maira Galdino da Rocha Pita   +5 more
doaj   +1 more source

Peroxisome proliferator-activated receptor γ coactivator 1 coactivators, energy homeostasis, and metabolism [PDF]

, 2006
Many biological programs are regulated at the transcriptional level. This is generally achieved by the concerted actions of several transcription factors. Recent findings have shown that, in many cases, transcriptional coactivators coordinate the overall
Christoph Handschin, Bruce M. Spiegelman, Handschin, C., Spiegelman, B. M.   +3 more
core   +2 more sources

Peroxisome Proliferator-Activated Receptors in Lung Cancer

PPAR Research, 2007
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. Their discovery in the 1990s provided insights into the cellular mechanisms involved in the control of ...
Venkateshwar G. Keshamouni, ShouWei Han, Jesse Roman   +2 more
doaj   +1 more source

Profiling of promoter occupancy by PPARalpha in human hepatoma cells via ChIP-chip analysis [PDF]

, 2010
The transcription factor peroxisome proliferator-activated receptor alpha (PPARalpha) is an important regulator of hepatic lipid metabolism. While PPARalpha is known to activate transcription of numerous genes, no comprehensive picture of PPARalpha ...
Degenhardt, Tatjana, de Groot, Philip, Merja Heinäniemi, Väisänen, Sami, de Groot, P.J., Carlberg, Carsten, Carsten Carlberg, de Vries, Sacco C, Müller, M.R., David L. M. van der Meer, Vries, Sacco, de, Philip J. de Groot, van der Meer, D.L., Degenhardt, T., Kersten, Sander, de Vries, Sacco, Heinaniemi, M., Vries, S.C., de, Kersten, A.H., Müller, Michael, Carlberg, C., Meer, D.L., van der, Sander Kersten, Michael Müller, Meer, D.L.M., van der, Groot, Philip, de, de Vries, S.C., Väisänen, S., Sami Väisänen, van der Meer, David L M, Groot, P.J., de, Heinäniemi, Merja, van der Meer, D.L.M., de Groot, Philip J, Tatjana Degenhardt, Sacco C. de Vries   +35 more
core   +1 more source

Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy

PPAR Research, 2008
Diabetic nephropathy is a leading cause of end-stage renal disease, which is increasing in incidence worldwide, despite intensive treatment approaches such as glycemic and blood pressure control in patients with diabetes mellitus.
Shinji Kume, Takashi Uzu, Keiji Isshiki, Daisuke Koya   +3 more
doaj   +1 more source

Peroxisome Proliferator-Activated Receptors and Shock State

The Scientific World Journal, 2006
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid, and thyroid hormone receptors.
Emanuela Esposito, Salvatore Cuzzocrea, Rosaria Meli   +2 more
doaj   +1 more source

Peroxisome Proliferator-Activated Receptor alpha (PPAR alpha) down-regulation in cystic fibrosis lymphocytes [PDF]

, 2006
Background: PPARs exhibit anti-inflammatory capacities and are potential modulators of the inflammatory response. We hypothesized that their expression and/or function may be altered in cystic fibrosis (CF), a disorder characterized by an excessive host ...
Wagner, Thomas, Reynders, Veerle, Veerle Reynders, Stefan Loitsch, Joachim Bargon, Reynders Veerle, Thomas Wagner, Steinhauer, Constanze, Bargon Joachim, Steinhilber Dieter, Bargon, Joachim, Loitsch Stefan, Dieter Steinhilber, Constanze Steinhauer, Loitsch, Stefan Marcel, Wagner Thomas, Steinhauer Constanze, Steinhilber, Dieter   +17 more
core   +2 more sources

Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor gamma coactivator 1alpha [PDF]

, 2010
Exercise triggers a pleiotropic response in skeletal muscle, which results in a profound remodeling of this tissue. Physical activity-dependent muscle fiber plasticity is regulated by a number of distinct signaling pathways.
Handschin, C.
core   +1 more source

Hepatic peroxisome proliferator-activated receptor γ and α-mRNA expression in HCV-infected adults is decreased by HIV co-infection and is also affected by ethnicity

Clinics, 2015
OBJECTIVE: To determine peroxisome proliferator activated receptor α and γ mRNA expression in liver tissue of hepatitis C virus-infected patients with and without human immunodeficiency virus and its possible contribution to an acceleration of liver ...
Nathan J. Shores, Maria Cássia Mendes-Corrêa, Ivana Maida, JoLyn Turner, Kevin P. High, Sergio Babudieri, Marina Núãez   +6 more
doaj   +1 more source

Crosstalk between Peroxisome Proliferator-Activated Receptors andToll-Like Receptors: A Systematic Review [PDF]

Advanced Pharmaceutical Bulletin, 2019
As one of the four major families of pattern recognition receptors (PRRs), toll like receptors (TLRs)are crucial and important components of the innate immune system. Peroxisome proliferatoractivatedreceptors (PPARs) with three isoforms are transcription
Nasim Dana, Golnaz Vaseghi, Shaghayegh Haghjooy-Javanmard   +2 more
doaj   +1 more source