Results 1 to 10 of about 114,476 (119)

RETRACTION: Synergistic Antiproliferative Effects of Combined γ-Tocotrienol and PPARγ Antagonist Treatment Are Mediated through PPARγ-Independent Mechanisms in Breast Cancer Cells [PDF]

PPAR Research
PPAR Research
doaj   +2 more sources

Effect of 6-Benzoyl-benzothiazol-2-one scaffold on the pharmacological profile of α-alkoxyphenylpropionic acid derived PPAR agonists

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A series of nitrogen heterocycles containing α–ethoxyphenylpropionic acid derivatives were designed as dual PPARα/γ agonist ligands for the treatment of type 2 diabetes (T2D) and its complications.
Aurélie Hurtevent, Morgan Le Naour, Veronique Leclerc, Pascal Carato, Patricia Melnyk, Nathalie Hennuyer, Bart Staels, Monique Beucher-Gaudin, Daniel-Henri Caignard, Catherine Dacquet, Nicolas Lebegue   +10 more
doaj   +1 more source

Two antibacterial and PPARα/γ-agonistic unsaturated keto fatty acids from a coral-associated actinomycete of the genus Micrococcus

Beilstein Journal of Organic Chemistry, 2020
A pair of geometrically isomeric unsaturated keto fatty acids, (6E,8Z)- and (6E,8E)-5-oxo-6,8-tetradecadienoic acids (1 and 2), were isolated from the culture broth of an actinomycete of the genus Micrococcus, which was associated with a stony coral ...
Amit Raj Sharma, Enjuro Harunari, Naoya Oku, Nobuyasu Matsuura, Agus Trianto, Yasuhiro Igarashi   +5 more
doaj   +1 more source

PPARγ induces PD-L1 expression in MSS+ colorectal cancer cells

OncoImmunology, 2021
Only a small subset of colorectal cancer (CRC) patients benefits from immunotherapies, comprising blocking antibodies (Abs) against checkpoint receptor “programmed-cell-death-1” (PD1) and its ligand (PD-L1), because most cases lack the required ...
Tobias Gutting, Veronika Hauber, Jens Pahl, Kay Klapproth, Wenyue Wu, Ioana Dobrota, Frank Herweck, Juliane Reichling, Laura Helm, Torsten Schroeder, Beifang Li, Philip Weidner, Tianzuo Zhan, Maximilian Eckardt, Johannes Betge, Sebastian Belle, Carsten Sticht, Timo Gaiser, Michael Boutros, Matthias P.A. Ebert, Adelheid Cerwenka, Elke Burgermeister   +21 more
doaj   +1 more source

Role of peroxisome proliferator-activated receptor α and ϒ-2 in primary and secondary prophylaxis of atherosclerosis

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2016
Literature review is devoted to the pathogenesis of atherosclerosis and pathogenetic mechanisms that determine the value of peroxisome proliferator-activated receptor (PPAR) in atherogenesis.
Z. I. Ionova, E. G. Sergeeva, O. A. Berkovich, S. N. Pchelina, E. I. Baranova   +4 more
doaj   +1 more source

Parsing the Role of PPARs in Macrophage Processes

Frontiers in Immunology, 2021
Cells are richly equipped with nuclear receptors, which act as ligand-regulated transcription factors. Peroxisome proliferator activated receptors (PPARs), members of the nuclear receptor family, have been extensively studied for their roles in ...
Daniel Toobian, Pradipta Ghosh, Pradipta Ghosh, Pradipta Ghosh, Pradipta Ghosh, Gajanan D. Katkar   +5 more
doaj   +1 more source

Synopsis: Special Issue on “Disruption of signaling homeostasis induced crosstalk in the carcinogenesis paradigm Epistemology of the origin of cancer”

4 open, 2019
It is increasingly evident that carcinogenesis, in the vast majority of cancers, cannot be explained simply through an accumulation of somatic mutations, or epigenetics, the stem cell theory, or the Warburg effect.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Thymoquinone prevents valproic acid-induced hepatotoxicity via modulation of cytochrome P450, PPARs, and apoptotic pathways [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Thymoquinone (TQ) is the main bioactive component of Nigella sativa L. and has anti-oxidant, anti-hepatotoxic, anti-cancer, anti-hypertensive, hypoglycemic, anti-inflammatory, and lipid-lowering properties.
Sebile Azirak, Sedat Bilgiç, Deniz Korkmaz, İlkay Armağan, Mehmet Kaya Özer   +4 more
doaj   +1 more source

Knockdown of PPAR δ gene promotes the growth of colon cancer and reduces the sensitivity to bevacizumab in nude mice model. [PDF]

PLoS ONE, 2013
The role of peroxisome proliferator--activated receptor- δ (PPAR δ) gene in colon carcinogenesis remains highly controversial. Here, we established nude mice xenograft model using a human colon cancer cell line KM12C either with PPAR δ silenced or normal.
Lie Yang, Jin Zhou, Qin Ma, Cun Wang, Keling Chen, Wenjian Meng, Yongyang Yu, Zongguang Zhou, Xiaofeng Sun   +8 more
doaj   +1 more source

Peroxisome proliferator activated receptor ligands affect porcine endometrial steroids production during the estrous cycle and early pregnancy: an in vitro study

Czech Journal of Animal Science, 2016
In the present study, we investigated the effect of PPAR ligands on progesterone (P4) and 17β-estradiol (E2) secretion, as well as 3β-hydroxysteroid dehydrogenase/Δ(5)-Δ(4) isomerase (3β-HSD) mRNA expression, in porcine endometrial slices collected on ...
A. Kurzyńska, M. Bogacki, K. Chojnowska, I. Bogacka   +3 more
doaj   +1 more source