Results 41 to 50 of about 1,310,860 (245)

Lipids, Inflammation and Pathology of the Human: Role of Peroxisome Prolifera tor-Activated Receptors (Literature Review)

Mìžnarodnij Endokrinologìčnij Žurnal, 2013
Chronic systemic indolent uncontrolled inflammation is the basis for the development of many chronic diseases, including atherosclerosis and its ischemic complications, hypertension, type 2 diabetes mellitus, hepatosteatosis and many others.
M.S. Rasin
doaj   +1 more source

Beta-carotene Reduces Body Adiposity of Mice Via BCMO1 [PDF]

, 2011
Evidence from cell culture studies indicates that ß-carotene-(BC)-derived apocarotenoid signaling molecules can modulate the activities of nuclear receptors that regulate many aspects of adipocyte physiology.
Yvonne G. J. van Helden, Georg Lietz, Kiec-Wilk, B., Andreu Palou, Adrian Wyss, von Lintig, J., Jean François Landrier, Landrier, Jean-Francois, Ursula Razny, Lietz, G., Raźny, Urszula, Kramer, E.H.M., Amengual, J., Wyss, A., Kramer, Evelien, Lietz, Georg, Gouranton, Erwan, M. Luisa Bonet, Razny, Ursula, Beata Kiec-Wilk, van Helden, Y.G., M Luisa Bonet, Joan Ribot, Susanne Hessel, Aldona Dembinska-Kiec, Jaap Keijer, Landrier, Jean François, Yvonne G J van Helden, Keijer, J., Hessel, S., Dembinska-Kiec, Aldona, Amengual, Jaume, Keijer, Jaap, Landrier, J. F., Bonet, M. Luisa, Ribot, Joan, Kramer, E., Dembinska-Kiec, A., Gouranton, E., Palou, Andreu, Kiec-Wilk, Beata, Ribot, J., Erwan Gouranton, Palou, A., Razny, U., Helden, Y.G.J., Johannes von Lintig, Wyss, Adrian, Hessel, Susanne, Evelien Kramer, van Helden, Yvonne G. J., Luisa Bonet, M., von Lintig, Johannes, Bonet, M.L., Jaume Amengual   +54 more
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Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Peroxisome Proliferator-Activated Receptors in Female Reproduction and Fertility

PPAR Research, 2016
Reproductive functions may be altered by the exposure to a multitude of endogenous and exogenous agents, drug or environmental pollutants, which are known to affect gene transcription through the peroxisome proliferator-activated receptors (PPARs ...
Maurizio Vitti, Giovanna Di Emidio, Michela Di Carlo, Gaspare Carta, Andrea Antonosante, Paolo Giovanni Artini, Annamaria Cimini, Carla Tatone, Elisabetta Benedetti   +8 more
doaj   +1 more source

PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression [PDF]

, 2008
Background The selective absorption of nutrients and other food constituents in the small intestine is mediated by a group of transport proteins and metabolic enzymes, often collectively called 'intestinal barrier proteins'.
Hooiveld, Guido J E J, Bosch, H.M., van den, de Groot, Philip, de Vogel-van den Bosch, Heleen, de Groot Philip J, de Groot, P.J., Hooiveld Guido JEJ, de Vogel-van den Bosch Heleen M, Müller, M.R., Bosch-Vermeulen, Hanneke, Heleen M de Vogel-van den Bosch, Hooiveld, Guido, Bosch - Vermeulen, Hanneke, Philip J de Groot, Bünger, Meike, Bosch-Vermeulen Hanneke, Bünger Meike, de Vogel-van den Bosch, Heleen M, Müller Michael, Müller, Michael, Meike Bünger, Michael Müller, Hanneke Bosch-Vermeulen, Bosch-Vermeulen, H., van den Bosch, H.M., Bünger, M., Groot, P.J., de, Guido JEJ Hooiveld, Heleen M de Vogel-van den Bosch, Hooiveld, G.J.E.J., de Groot, Philip J   +30 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Peroxisome Proliferator-activated receptor alpha gene variation influences age of onset and progression of type 2 diabetes [PDF]

, 2005
Dysregulation of fatty acid metabolism is important in the pathogenesis of type 2 diabetes. Peroxisome proliferator-activated receptor (PPAR) is a master regulator of fatty acid catabolism, and PPAR activators delay the onset of type 2 diabetes.
Ireland, H., Humphries, S.E., Hawe, E., Stephens, J.W., Acharya, J., Mather, H., Flavell, D.M., Hurel, S.J.   +7 more
core  

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Loss of Renal Tubular PGC-1α Exacerbates Diet-Induced Renal Steatosis and Age-Related Urinary Sodium Excretion in Mice [PDF]

, 2016
The kidney has a high energy demand and is dependent on oxidative metabolism for ATP production. Accordingly, the kidney is rich in mitochondria, and mitochondrial dysfunction is a common denominator for several renal diseases.
Handschin, Christoph, Kristoffer Svensson, Schnyder, Svenia, Christoph Handschin, Kristoffer Svensson (593634), Svenia Schnyder (3146877), Svensson, Kristoffer, Bettina Cardel (3146880), Svenia Schnyder, Christoph Handschin (184204), Cardel, Bettina, Bettina Cardel   +11 more
core   +1 more source