Results 51 to 60 of about 1,310,860 (245)

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases

Journal of Advanced Pharmaceutical Technology & Research, 2011
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/δ.
Sandeep Tyagi, Paras Gupta, Arminder Singh Saini, Chaitnya Kaushal, Saurabh Sharma   +4 more
doaj   +1 more source

Endogenous Epoxygenases Are Modulators of Monocyte/Macrophage Activity [PDF]

, 2011
Background: Arachidonic acid is metabolized through three major metabolic pathways, the cyclooxygenase, lipoxygenase and CYP450 enzyme systems. Unlike cyclooxygenase and lipoxygenases, the role of CYP450 epoxygenases in monocyte/macrophage-mediated ...
Bishop-Bailey, D, Mary C Sugden, David Bishop-Bailey, Bystrom, J, Holness Mark J., Sugden, MC, Mark J Holness, Holness, MJ, Jessica A. Wray, Wray, JA, Sugden, M C, Matthew L. Edin, Zeldin Darryl C., Zeldin, DC, Karen E Swales, Edin Matthew L., Edin, ML, Zeldin, D C, Sugden Mary C., Wray, J A, Gilroy Derek W., Swales Karen E., Darryl C Zeldin, Gilroy, DW, Derek W Gilroy, Karen E. Swales, Edin, M L, Mark J. Holness, Matthew L Edin, Derek W. Gilroy, Wray Jessica A., Gilroy, D W, Warner Timothy D., Jonas Bystrom, Warner, T D, Darryl C. Zeldin, Timothy D. Warner, Bishop-Bailey David, Bystrom Jonas, Holness, M J, Jessica A Wray, Swales, K E, Warner, TD, Timothy D Warner, Swales, KE, Mary C. Sugden   +45 more
core   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Magneto‐NIR‐II‐Programmed Cascade Nanozymes Unlocking Blood–Brain Barrier Translocation and Autophagic Resistance in Glioblastoma

Advanced Science, EarlyView.
Magneto‐NIR‐II‐programmed NFSH nanozymes integrate magnetic blood–brain barrier (BBB) translocation, CD44 targeting, multimodal imaging, and cascade catalytic therapy for glioblastoma. Alternating magnetic fields and NIR‐II irradiation amplify ferroptosis, release H2S, suppress autophagic and mitophagic repair, and reshape the immune microenvironment ...
Ruocan Liu, Yundi Wu, Shuai Zhang, Hongjuan Zhao, Jiping Zheng, Shiyang Shao, Jianqiang Chen, Xilong Wu   +7 more
wiley   +1 more source

Topical rosiglitazone is an effective anti-scarring agent in the cornea [PDF]

, 2013
Corneal scarring remains a major cause of blindness world-wide, with limited treatment options, all of which have side-effects. Here, we tested the hypothesis that topical application of Rosiglitazone, a Thiazolidinedione and ligand of peroxisome ...
Phipps, Richard P., Holly B Hindman, MacRae, Scott, Patricia J Sime, Krystel R Huxlin, David Ciufo, Jeon, Kye-Im, Richard P Phipps, Sime, Patricia J., DeMagistris, Margaret, Ciufo, David, Huxlin, Krystel R., Jens Bühren, Scott MacRae, Kye-Im Jeon, Margaret DeMagistris, Bühren, Jens, Hindman, Holly B.   +17 more
core   +2 more sources

m6A‐Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress

Advanced Science, EarlyView.
Prenatal environmental stress exposure promotes m6A modification to drive PEX2‐dependent pexophagy, thereby causing placental ferroptosis and FGR. ABSTRACT The role and underlying mechanisms of placental ferroptosis in fetal growth restriction (FGR) induced by environmental stress remain poorly understood.
Xin‐Xin Zhang, Ye‐Xin Luo, Cheng‐Fang Sun, Rui Pan, Yu‐Xi Wu, Zhi Yuan, Xin‐Run Wang, Xu‐Dong Zhang, Lan‐Lan Wu, Xiang‐Yu Yao, Zhan‐Dong Song, Wei Chang, Tian Wei, Pan‐Yuan Cai, Tian‐Ci Zhang, Yong‐Wei Xiong, De‐Xiang Xu, Hua Wang, Hua‐Long Zhu   +18 more
wiley   +1 more source

Role of metabolic nuclear receptors in acute liver injury and drug-induced hepatotoxicity

Pharmacological Research
Metabolic nuclear receptors (NRs) are ligand-activated transcription factors central to metabolic homeostasis and detoxification. While their roles in chronic liver diseases have been reviewed, comprehensive reviews specifically addressing the role of ...
Liangliang Nie, Nana Yan, Frank J. Gonzalez, Haiping Hao, Tingting Yan   +4 more
doaj   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Expression studies on PPARγ in pancreatic neuroendocrine tumours [PDF]

, 2010
MDPancreatic NETs occur with an annual incidence of around 5 per 1,000,000 population per year, with survival rates of between 30 – 97% at 5 years depending on the tumour subtype.
Hanson, Matthew Richard
core   +4 more sources