Peroxisome Proliferator-Activated Receptors and Acute Lung Injury
PPAR Research, 2007 Peroxisome proliferator-activated receptors are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. PPARs regulate several metabolic pathways by binding to sequence-specific PPAR response elements in the promoter
Rosanna Di Paola, Salvatore Cuzzocrea
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Variants of the human PPARG locus and the susceptibility to chronic periodontitis [PDF]
, 2011 Apart from its regulatory function in lipid and glucose metabolism, peroxisome proliferator-activated receptor (PPAR)γ has impact on the regulation of inflammation and bone metabolism.
Manolis, Vasilios +7 more
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Peroxisome Proliferator-Activated Receptors in HBV-Related Infection
PPAR Research, 2009 Thirty years after its discovery, the hepatitis B virus (HBV) still remains a major global public health problem. Worldwide, two billion subjects have been infected, 350 million have a chronic infection and more than 600 000 die annually of HBV-related ...
Laurent Dubuquoy +4 more
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Peroxisome proliferator-activated receptor-γ coactivator-1α in muscle links metabolism to inflammation [PDF]
, 2009 1. In higher eukaryotes, metabolism and immunity are tightly coupled. However, whereas evolutionary, a compromised immune response due to undernourishment has been the predominant problem, the inflammatory response to obesity and other life style ...
Handschin, C., Handschin, C
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Peroxisome Proliferator-Activated Receptors in HCV-Related Infection
PPAR Research, 2009 The topic of peroxisome proliferator-activated receptors has been developed in the field of hepatology allowing envisaging therapeutic strategies for the most frequent chronic liver diseases such as chronic infection with hepatitis C virus (HCV).
Sébastien Dharancy +4 more
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Kinetic characterization of selective peroxisome-proliferator-activated receptor gamma modulators in vitro [PDF]
, 2012 Background: The ligand-activated transcription factor, peroxisome-proliferator-activated receptor gamma (PPARγ), has been shown to play an essential role in immunosuppression during sepsis.
Parnham, Michael J. +6 more
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Peroxisome proliferator-activated receptors and hepatitis C virus
Therapeutic Advances in Gastroenterology, 2011 The prevalence of type 2 diabetes mellitus and insulin resistance are higher among people chronically infected with hepatitis C (CHC) when compared with the general population and people with other causes of chronic liver disease. Both insulin resistance
M. Eslam +2 more
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The Peroxisome Proliferator-activated Receptor γ (PPARγ) Controls Natural Protective Mechanisms against Lipid Peroxidation in Amyotrophic Lateral Sclerosis [PDF]
, 2012 Recent evidence highlights the peroxisome proliferator-activated receptors (PPARs) as critical neuroprotective factors in several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). To gain new mechanistic insights into the role of
Maggi, Adriana +8 more
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Skin-targeted inhibition of PPAR β/δ by selective antagonists to treat PPAR β/δ-mediated psoriasis-like skin disease in vivo [PDF]
, 2012 We have previously shown that peroxisome proliferator activating receptor ß/d (PPAR ß/d is overexpressed in psoriasis. PPAR ß/d is not present in adult epidermis of mice.
Kevin D. Read (165019) +33 more
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source