Results 61 to 70 of about 43,347 (215)

Direct rosiglitazone action on steroidogenesis and proinflammatory factor production in human granulosa-lutein cells

Reproductive Biology and Endocrinology, 2009
Background Ovarian granulosa cells are the predominant source of estradiol and progesterone biosynthesis in vivo. Rosiglitazone, a synthetic agonist of the peroxisome proliferator-activated receptor gamma (PPAR gamma), is applied as the treatment of ...
Wang Yongwei, Wang Jian, Cheng Linan, Chen Junling, Sun Xiaoxi, Chen Qiuju, Sun Zhaogui   +6 more
doaj   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

GC-MS and molecular docking studies of Hunteria umbellata methanolic extract as a potent anti-diabetic

Informatics in Medicine Unlocked, 2018
Background: The purpose of this study was to investigate the diabetic effect of phytocompounds synthesized from Hunteria umbellata using GC-MS analysis and molecular docking studies.
Olusola Abiola Ladokun, Aminu Abiola, Durosinlorun Okikiola, Famuti Ayodeji   +3 more
doaj   +1 more source

The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis

PPAR Research, 2020
PPARs are ligand-activated transcriptional factors that belong to the nuclear receptor superfamily. Among them, PPAR alpha and PPAR gamma are prone to exert an antiangiogenic effect, whereas PPAR beta/delta has an opposite effect in physiological and ...
Siyue Du, Nicole Wagner, Kay-Dietrich Wagner   +2 more
doaj   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Fenretinide inhibits macrophage inflammatory mediators and controls hypertension in spontaneously hypertensive rats via the peroxisome proliferator-activated receptor gamma pathway

Drug Design, Development and Therapy, 2016
Ching-Han Lin,1,* Shang-Yu Lee,2,* Chun-Cheng Zhang,3 Ye-Fong Du,1 Hao-Chang Hung,1 Hung-Tsung Wu,4 Horng-Yih Ou1 1Department of Internal Medicine, Division of Endocrinology and Metabolism, National Cheng Kung University Hospital, College of Medicine ...
Lin CH, Lee SY, Zhang CC, Du YF, Hung HC, Wu HT, Ou HY   +6 more
doaj  

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

Regulation of Pancreatic Fibrosis by Acinar Cell-Derived Exosomal miR-130a-3p via Targeting of Stellate Cell PPAR-γ

Journal of Inflammation Research, 2021
Qiang Wang,* Hao Wang,* Qingxu Jing, Yang Yang, Dongbo Xue, Chenjun Hao, Weihui Zhang Department of General Surgery, Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin ...
Wang Q, Wang H, Jing Q, Yang Y, Xue D, Hao C, Zhang W   +6 more
doaj  

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

Subchronic Exposure to Cannabis‐Based Nanoemulsions Induces Histopathological and Molecular Alterations in the Rat Submandibular Gland

Journal of Applied Toxicology, EarlyView.
ABSTRACT The increasing therapeutic incorporation of cannabis has expanded phytocannabinoid application, yet peripheral adverse effects like xerostomia raise concerns regarding emerging biotechnological formulations. This study evaluated the effects of cannabis‐based lipid nanoemulsions on the rat submandibular gland parenchyma.
Lorrany Avanci Bullo, Gabriel Carvalhal de Aguiar, Daniel Vitor Souza, Barbara dos Anjos Rosário, Flavia de Oliveira, Fernando Augusto Cintra Magalhaes, Nágila Maria Pontes Silva Ricardo, Edilberto Rocha Silveira, Dávila Zampieri, Milena de Barros Viana, Daniel Araki Ribeiro   +10 more
wiley   +1 more source