Results 71 to 80 of about 43,347 (215)

Gas chromatography–mass spectrometry analysis and comprehensive evaluation of antibacterial, antioxidant and anti‐inflammatory properties of Thymus capitatus extracts from Libya

JSFA reports, EarlyView.
Abstract Background The emergence of multidrug‐resistant bacteria necessitates the development of alternative therapeutic approaches. Thymus capitatus, a Mediterranean medicinal plant, has been traditionally used to treat various ailments, but its bioactive potential from Libyan origins remains underexplored.
Ahmed Saeed Kabbashi, Taher Issa Shailabi, Ahlam Mohamed Keshar, Amel Mahmoud Abdrabo, Ahmed Ali Mustafa, Bushray Salih Jabullah, Rama Burhan Hasan, Mona Rafea Mosa, Esraa Radwan Ibrahim, Maryam Mohammed Ibrahim   +9 more
wiley   +1 more source

Gymnema sylvestre: Bioactive constituents, health benefits, and emerging applications in nutraceuticals and functional foods

JSFA reports, EarlyView.
Abstract Gymnema sylvestre (Retz.) R.Br. ex‐Schult., commonly known as “gurmar” or “sugar destroyer,” belongs to the Apocynaceae family and is traditionally used in Ayurveda for diabetes management. This review synthesizes ethnomedicinal evidence with contemporary pharmacological studies, to evaluate the therapeutic properties and mechanistic actions ...
Faiza Saeed, Muhammad Tauseef Sultan, Hassan Raza, Ahmad Mujtaba Noman, Nimra Haroon, Entessar Mohammad Al Jbawi   +5 more
wiley   +1 more source

Ferroptosis and PPAR-gamma in the limelight of brain tumors and edema. [PDF]

Front Oncol, 2023
Yakubov E, Schmid S, Hammer A, Chen D, Dahlmanns JK, Mitrovic I, Zurabashvili L, Savaskan N, Steiner HH, Dahlmanns M.   +9 more
europepmc   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Studies on the contribution of PPAR Gamma to tuberculosis physiopathology. [PDF]

Front Cell Infect Microbiol, 2023
Díaz A, D'Attilio L, Penas F, Bongiovanni B, Massa E, Cevey A, Santucci N, Bottasso O, Goren N, Bay ML.   +9 more
europepmc   +1 more source

Synthesis of Microbial‐Derived Octadecanoids

Lipids, EarlyView.
C18‐carbon containing dietary polyunsaturated fatty acids (e.g., linoleic acid, α‐linolenic acid, and γ‐linolenic acid) are metabolized by bacteria in the gut into oxygenated lipid mediators termed octadecanoids. To study the biological function of these compounds, we report here the chemical synthesis of multiple octadecanoids.
Johanna Revol‐Cavalier, Katarína Bankóová, Olivier Salamin, Alessandro Quaranta, Juan Du, Mats Hamberg, Craig E. Wheelock   +6 more
wiley   +1 more source

The Role of PPAR Gamma in Systemic Sclerosis

PPAR Research, 2015
Fibrosis is recognized as an important feature of many chronic diseases, such as systemic sclerosis (SSc), an autoimmune disease of unknown etiology, characterized by immune dysregulation and vascular injury, followed by progressive fibrosis affecting ...
Andréa Tavares Dantas, Michelly Cristiny Pereira, Moacyr Jesus Barreto de Melo Rego, Laurindo Ferreira da Rocha, Ivan da Rocha Pitta, Cláudia Diniz Lopes Marques, Angela Luzia Branco Pinto Duarte, Maira Galdino da Rocha Pitta   +7 more
doaj   +1 more source

PPAR Gamma Receptor: A Novel Target to Improve Morbidity in Preterm Babies. [PDF]

Pharmaceuticals (Basel), 2023
Victor S, Forbes B, Greenough A, Edwards AD.   +3 more
europepmc   +1 more source

Incretin‐Based Therapies: A Testable Hypothesis Linking Incretin Signaling, Mitochondrial Redox, and OXPHOS Efficiency

Obesity, EarlyView.
ABSTRACT Objective Incretin‐based obesity therapies (IBTs), especially GLP‐1 receptor agonists (GLP‐1 RAs), effectively treat obesity and improve comorbidities. However, their impact on energy metabolism is unclear. A recent case of acute generalized muscle weakness in a patient with mitochondrial myopathy after tirzepatide exposure raises concerns ...
Bryn Falahee, Caroline M. Apovian, Nawfal Istfan   +2 more
wiley   +1 more source

Proteomic Analysis of Mixed Cell Membrane Extracts From Triple‐Negative Breast Cancer Cell Lines Revealed Broad Metabolic Reprogramming Associated With Tumor Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca, Violeta Larios‐Serrato, María Luisa Labra‐Barrios, Emmanuel Ríos‐Castro, Carlos Alberto Castañón‐Sánchez, Rodolfo Moreno‐Castillo, Erika Beatriz Ángeles‐Morales, Juan Pedro Luna‐Arias   +7 more
wiley   +1 more source