Results 51 to 60 of about 1,172 (173)
Thalassemia Reports, 2023 β-thalassemia is a genetic disorder affecting chromosome 16, inherited from one or both parents. In spite of the improved treatment of the hematological disorder and its complications, β-thalassemic patients still exhibit an imbalance in bone mineral ...
Ahmed M. Abdel Hamied +11 more
doaj +1 more source
Pediatric Obesity, Volume 20, Issue 3, March 2025.Summary Background Although the genetic interplay with the environment has a major impact on obesity development, little is known on whether breastfeeding could modulate the genetic predisposition to obesity. Objectives To investigate whether breastfeeding attenuates the effect of an obesity genetic risk score (GRS) on adiposity in European adolescents.
Georgios K. Baxevanis +20 more
wiley +1 more source
BMC Medical Genetics, 2005 Background The Pro12Ala Single Nucleotide Polymorphism (SNP) of the Peroxisome Proliferator-Activated Receptor gamma 2 (PPAR-gamma 2) has been associated with insulin resistance and type 2 diabetes (T2D) and also inconsistently with obesity.
Charles Marie-Aline +8 more
doaj +1 more source
Molecular Nutrition &Food Research, Volume 69, Issue 3, February 2025.No robust evidence for associations between TCF7L2, PPARγ, or KCNJ11 genotypes and postprandial insulin AUC after an oral glucose tolerance test (OGTT) was found. ABSTRACT Scope: Insulin responses to standardized meals differ between individuals. This variability may in part be explained by genotype.
Carmen P. S. Blanken +4 more
wiley +1 more source
Association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma gene and strength athlete status. [PDF]
PLoS ONE, 2013 BackgroundThe 12Ala allele of the Peroxisome Proliferator-Activated Receptor gamma gene (PPARG) Pro12Ala polymorphism produces a decreased binding affinity of the PPARγ2 protein, resulting in low activation of the target genes.
Agnieszka Maciejewska-Karlowska +4 more
doaj +1 more source
Exploration, Volume 4, Issue 5, October 2024.The coexistence of diabetes mellitus (DM) and tuberculosis (TB) presents a significant global burden, with DM being recognized as a major risk factor for TB. This review comprehensively analyzes the immunological aspects of DM‐TB comorbidity, shedding light on the impact of DM on TB pathogenesis and immune responses.
Zhaoyang Ye +6 more
wiley +1 more source
PPAR Research, 2019 TNFα and PPARγ are important modulators of metabolism, inflammation, and atherosclerosis. Coronary artery disease is the leading cause of heart failure (HF).
Izabela Wojtkowska +6 more
doaj +1 more source
Pro12Ala and His447His polymorphisms of PPAR-γ are associated with polycystic ovary syndrome
Reproductive BioMedicine Online, 2009 Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects 4-12% of women of reproductive age, and is specified when two of the three following criteria are present: hyperandrogenism, oligomenorrhoea and polycystic ovary morphology by ultrasonography. PCOS is characterized by infertility, obesity and hyperinsulinaemia.
Bon-Hee, Gu, Kwang-Hyun, Baek
openaire +2 more sources
Effects of the PPARG gene polymorphisms on markers of obesity and the metabolic syndrome in Bosnian subjects [PDF]
Journal of Medical Biochemistry, 2014 Background: Peroxisome proliferator-activated receptor gamma (PPARg) is a key transcription factor in adipogenesis, and also regulates a number of genes associated with lipid storage and insulin sensitivity.
Dujić Tanja +8 more
doaj
Balkan Journal of Medical Genetics, 2017 Peroxisome proliferator-activated receptor γ (PPARγ) is a key regulator of metabolism, adipokines production and secretion. The aim of this study was to investigate the association between the PPARγ2 gene Pro12Ala polymorphism in obesity in terms of body
Becer E, Çırakoğlu A
doaj +1 more source