Results 61 to 70 of about 3,653 (217)

Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population

BMC Medical Genetics, 2005
Background The Pro12Ala Single Nucleotide Polymorphism (SNP) of the Peroxisome Proliferator-Activated Receptor gamma 2 (PPAR-gamma 2) has been associated with insulin resistance and type 2 diabetes (T2D) and also inconsistently with obesity.
Charles Marie-Aline, Clément Karine, Charpentier Guillaume, Lobbens Stéphane, Meyre David, Ghoussaini Maya, Tauber Maïté, Weill Jacques, Froguel Philippe   +8 more
doaj   +1 more source

PPAR α and PPAR γ Polymorphisms as risk factors for Dyslipidemia in a Chinese han population [PDF]

, 2014
BACKGROUND: The PPAR α and PPAR γ are the key messengers responsible for the translation of nutritional stimuli into changes for the expression of genes, particularly genes involved in lipid metabolism.
Ming Wu, Shu-Jun Gu, Xiao-Shu Hu, Zheng-Yuan Zhou, Zhi-Rong Guo   +4 more
core   +1 more source

Mitigation of Metabolic Diseases Through Personalized Nutrition: A Critical In‐Depth Review

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
The main objective of this review is to explore the impact of variation within the microbiome and among genes on nutrient metabolism and argue in favor of successful evidence of individualized dietary intervention for cardiovascular disease, diabetes, and obesity.
Muhammad Tayyab Arshad, M. K. M. Ali, Farhang Hameed Awlqadr, Sammra Maqsood, Ali Ikram, Md. Sakhawot Hossain, Muhammed Adem Abdullahi, M. M. Rashed   +7 more
wiley   +1 more source

Association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma gene and strength athlete status. [PDF]

PLoS ONE, 2013
BackgroundThe 12Ala allele of the Peroxisome Proliferator-Activated Receptor gamma gene (PPARG) Pro12Ala polymorphism produces a decreased binding affinity of the PPARγ2 protein, resulting in low activation of the target genes.
Agnieszka Maciejewska-Karlowska, Marek Sawczuk, Pawel Cieszczyk, Aleksandra Zarebska, Stanislaw Sawczyn   +4 more
doaj   +1 more source

Interaction between breastfeeding duration and an obesity genetic risk score to predict body fat composition in European adolescents: The HELENA study

Pediatric Obesity, Volume 20, Issue 3, March 2025.
Summary Background Although the genetic interplay with the environment has a major impact on obesity development, little is known on whether breastfeeding could modulate the genetic predisposition to obesity. Objectives To investigate whether breastfeeding attenuates the effect of an obesity genetic risk score (GRS) on adiposity in European adolescents.
Georgios K. Baxevanis, Iris Iglesia, Miguel Seral‐Cortes, Sergio Sabroso‐Lasa, Paloma Flores‐Barrantes, Frédéric Gottrand, Aline Meirhaeghe, Anthony Kafatos, Kurt Widhalm, Nele Hockamp, Dénes Molnár, Ascensión Marcos, Esther Nova, Marcela González‐Gross, Eva Gesteiro, Ángel Gutiérrez, Yannis Manios, Costas A. Anastasiou, Gerardo Rodríguez, Luis A. Moreno, on behalf of the HELENA Study Group   +20 more
wiley   +1 more source

Genetic Predictors of Weight Loss and Weight Regain After Intensive Lifestyle Modification, Metformin Treatment, or Standard Care in the Diabetes Prevention Program [PDF]

, 2012
OBJECTIVE: We tested genetic associations with weight loss and weight regain in the Diabetes Prevention Program, a randomized controlled trial of weight loss–inducing interventions (lifestyle and metformin) versus placebo.
Delahanty, Linda M., Florez, Jose C., Franks, Paul,, Jablonski, Icatiileen A., Kahn, Steven E., Knowler, William C., Lund University., Lund University., Lund University., McCaffery, Jeanne M., Pan, Qing, Shuldiner, Alan, Watson, Karol E.   +12 more
core   +1 more source

Associations Between TCF7L2, PPARγ, and KCNJ11 Genotypes and Insulin Response to an Oral Glucose Tolerance Test: A Systematic Review

Molecular Nutrition &Food Research, Volume 69, Issue 3, February 2025.
No robust evidence for associations between TCF7L2, PPARγ, or KCNJ11 genotypes and postprandial insulin AUC after an oral glucose tolerance test (OGTT) was found. ABSTRACT Scope: Insulin responses to standardized meals differ between individuals. This variability may in part be explained by genotype.
Carmen P. S. Blanken, Sandra Bayer, Sophie Buchner Carro, Hans Hauner, Christina Holzapfel   +4 more
wiley   +1 more source

Impact of diabetes mellitus on tuberculosis prevention, diagnosis, and treatment from an immunologic perspective

Exploration, Volume 4, Issue 5, October 2024.
The coexistence of diabetes mellitus (DM) and tuberculosis (TB) presents a significant global burden, with DM being recognized as a major risk factor for TB. This review comprehensively analyzes the immunological aspects of DM‐TB comorbidity, shedding light on the impact of DM on TB pathogenesis and immune responses.
Zhaoyang Ye, Linsheng Li, Ling Yang, Li Zhuang, Ashok Aspatwar, Liang Wang, Wenping Gong   +6 more
wiley   +1 more source

Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity [PDF]

, 1982
7 pages, 2 tables.-- Results from this work were presented at the 85th Annual Meeting of The Endocrine Society, Philadelphia, PA, June 2003.We have evaluated the possible association of polycystic ovary syndrome (PCOS) with 15 genomic variants ...
San Millán, José L., Cortón, Marta, Villuendas, Gemma, Sancho, José, Peral, Belén, Escobar-Morreale, Héctor F.   +5 more
core   +1 more source

Association of the PPARγ2 Pro12Ala polymorphism with increased risk of cardiovascular diseases

Genetics and Molecular Research, 2015
This meta-analysis investigated the correlation between the PPARγ2 Pro12Ala polymorphism and cardiovascular disease (CVD). Electronic database and manual searches were conducted to retrieve studies published relevant to the PPARγ2 Pro12Ala polymorphism and CVD.
Y, Li, J, Zhu, J Q, Ding
openaire   +2 more sources