Results 51 to 60 of about 1,103 (148)

Population Pharmacokinetic and Pharmacodynamic Analysis of Voriconazole‐Induced Liver Injury in Chinese Lung Transplant Patients

Journal of Clinical Pharmacy and Therapeutics, Volume 2026, Issue 1, 2026.
Background Voriconazole (VCZ) served as primary therapy for invasive aspergillosis in lung transplant recipients. However, VCZ‐induced hepatotoxicity emerged as a frequent adverse effect that critically compromised postoperative management and complication prevention in this vulnerable population.
Dan Zhang, Wenwen Du, Wei Qin, Bo Li, Pengmei Li, Xiaoxing Wang, Wenqian Chen, Anjali Chauhan   +7 more
wiley   +1 more source

Genetic Biomarkers for Periodontal Diseases: A Systematic Review

Journal of Clinical Periodontology, Volume 52, Issue S29, Page 182-210, August 2025.
ABSTRACT Aims To identify genetic biomarkers that may be used in the diagnosis, prevention or management of different forms of periodontal disease. Materials and Methods Following protocol registration and PICOTS (patient, intervention, comparison, outcome, time, studies) questions, a systematic search of the literature was conducted (PudMed, Ovid ...
H. Dommisch, D. Hoedke, E. M.‐C. Lu, A. Schäfer, G. Richter, J. Kang, L. Nibali   +6 more
wiley   +1 more source

Metabolic biomarkers in patients with type 2 diabetes mellitus and heart failure with preserved ejection fraction

Сахарный диабет
BACKGROUND: Half of all patients with chronic heart failure (CHF) have preserved ejection fraction (CHF-nEF). The drug’s use effective for treatment of CHF with reduced ejection fraction (CHF-nFV) reduces the hospitalization incidence but does not affect
T. S. Sveklina, S. B. Shustov, S. N. Kolyubayeva, A. N. Kuchmin, V. A. Kozlov, E. V. Smirnova, A. V. Zharkov   +6 more
doaj   +1 more source

Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues

Obesity Reviews, Volume 25, Issue 8, August 2024.
Summary Obesity stands as a formidable global health challenge, predisposing individuals to a plethora of chronic illnesses such as cardiovascular disease, diabetes, and cancer. A confluence of genetic polymorphisms, suboptimal dietary choices, and sedentary lifestyles significantly contribute to the elevated incidence of obesity.
Sara K. AlMarzooqi, Fajr Almarzooqi, Hana Q. Sadida, Jayakumar Jerobin, Ikhlak Ahmed, Abdul‐Badi Abou‐Samra, Khalid A. Fakhro, Punita Dhawan, Ajaz A. Bhat, Ammira S. Al‐Shabeeb Akil   +9 more
wiley   +1 more source

Effect of thiazolidinediones on dislipidemia in patients with metabolic syndrome depending on the gene PPAR-gamma rs1801282 polymorphism

HERALD of North-Western State Medical University named after I.I. Mechnikov, 2019
Background. To evaluate the effect of thiazolidinediones on lipid spectrum of blood in patients with metabolic syndrome depending on gene polymorphism rs1801282. Materials and methods. The study included 109 patients with newly diagnosed metabolic syndrome.
Tatyana V. Eremenko, Svetlana M. Kotova, Natalya V. Vorokhobina, Nikolay A. Matsievskiy, Irina Yu. Matezius   +4 more
openaire   +2 more sources

Association of PPARG gene variants with obesity in South Indian young adults: a cross-sectional study

BMJ Connections Clinical Genetics and Genomics
Introduction Peroxisome proliferator-activated receptor gamma (PPARG) gene polymorphisms, particularly rs1801282 (Pro12Ala) and rs3856806 (C161T), have been implicated in obesity, but findings remain inconsistent across populations.
Shobha C Ramachandra, Cylvia Alphones Luke Jeeva Amala Rani, Raveen Nagaraje Gowda, Vaibhavishree Muniswamy, Anju Srinivas   +4 more
doaj   +1 more source

Тhe study of Association of gene polymorphism with sports success and risk of alimentary-dependent diseases in athletes representing cyclic sports

Спортивная медицина: наука и практика, 2020
The studies of genetic polymorphisms rs1815739 (ACTN3 gene), rs2016520 (gene PPARD), rs1042713 (ADRB2 gene), rs1799945 (HFE gene), rs1801282 (PPARG gene) of athletes involved in cyclic sports were carried out.
E. Yu. Sorokina, E. E. Keshabyants, N. N. Denisova   +2 more
doaj   +1 more source

Type 2 diabetes-associated genetic variants of FTO, LEPR, PPARg, and TCF7L2 in gestational diabetes in a Brazilian population

Archives of Endocrinology and Metabolism, 2017
Objective Gestational diabetes mellitus (GDM) is a metabolic disorder that shares pathophysiologic features with type 2 diabetes mellitus. The aim of this study was to investigate the association of the polymorphisms fat mass and obesity-associated (FTO)
Mauren Isfer Anghebem-Oliveira, Bruna Rodrigues Martins, Dayane Alberton, Edneia Amancio de Souza Ramos, Geraldo Picheth, Fabiane Gomes de Moraes Rego   +5 more
doaj   +1 more source

Effect of Pro12Ala polymorphism of PPARG gene on lipid peroxidation and antioxidant defense in patients with type 2 diabetes depending on the duration of the disease

Patologìâ, 2016
Aim – to study the impact of polymorphic marker rs1801282 of gene PPARG on the formation of oxidative stress in terms of LPO and AOS in patients with type 2 diabetes depending on the duration of the disease. Materials and methods.
V. Y. Mokrii, S. V. Ziablytsev
doaj   +1 more source

A meta-analysis of the association of PPARγ rs1801282 polymorphism and NSAID usage with the risk of developing cancer.

Biological & pharmaceutical bulletin, 2014
Use of nonsteroidal anti-inflammatory drugs (NSAIDs) is correlated with a reduced risk of cancer through the reduction of inflammation, which is an important risk factor. Several studies have investigated polymorphisms in the peroxisome proliferator-activated receptor gamma (PPARγ) gene and NSAID use in association with cancer risk.
Nagao, Mai, Sato, Youichi, Yamauchi, Aiko   +2 more
openaire   +2 more sources