Results 51 to 60 of about 2,006 (194)

Genetic Predictors of Weight Loss and Weight Regain After Intensive Lifestyle Modification, Metformin Treatment, or Standard Care in the Diabetes Prevention Program [PDF]

, 2012
OBJECTIVE: We tested genetic associations with weight loss and weight regain in the Diabetes Prevention Program, a randomized controlled trial of weight loss–inducing interventions (lifestyle and metformin) versus placebo.
Delahanty, Linda M., Florez, Jose C., Franks, Paul,, Jablonski, Icatiileen A., Kahn, Steven E., Knowler, William C., Lund University., Lund University., Lund University., McCaffery, Jeanne M., Pan, Qing, Shuldiner, Alan, Watson, Karol E.   +12 more
core   +1 more source

Ethnic differences in adiposity and diabetes risk – insights from genetic studies

Journal of Internal Medicine, Volume 288, Issue 3, Page 271-283, September 2020., 2020
Content List ‐ Read more articles from the symposium: “Obesity and Type 2 Diabetes: Understanding the Role of Ethnicity”. Abstract Type 2 diabetes is more common in non‐Europeans and starts at a younger age and at lower BMI cut‐offs. This review discusses the insights from genetic studies about pathophysiological mechanisms which determine risk of ...
H. Yaghootkar, B. Whitcher, J. D. Bell, E. L. Thomas   +3 more
wiley   +1 more source

Functional informed genome‐wide interaction analysis of body mass index, diabetes and colorectal cancer risk

Cancer Medicine, Volume 9, Issue 10, Page 3563-3573, May 2020., 2020
Novel findings of this study include: the genetically predicted expressions of FOXA1, PSMC5 and CD33 modified the association of BMI on CRC risk for men; KIAA0753 and SCN1B modified the association of BMI on CRC risk for women; and PTPN2 modified the association between diabetes and CRC risk in both sexes.
Zhiyu Xia, Yu‐Ru Su, Paneen Petersen, Lihong Qi, Andre E. Kim, Jane C. Figueiredo, Yi Lin, Hongmei Nan, Lori C. Sakoda, Demetrius Albanes, Sonja I. Berndt, Stéphane Bézieau, Stephanie Bien, Daniel D. Buchanan, Graham Casey, Andrew T. Chan, David V. Conti, David A. Drew, Steven J. Gallinger, W. James Gauderman, Graham G. Giles, Stephen B. Gruber, Marc J. Gunter, Michael Hoffmeister, Mark A. Jenkins, Amit D. Joshi, Loic Le Marchand, Juan P. Lewinger, Li Li, Noralane M. Lindor, Victor Moreno, Neil Murphy, Rami Nassir, Polly A. Newcomb, Shuji Ogino, Gad Rennert, Mingyang Song, Xiaoliang Wang, Alicja Wolk, Michael O. Woods, Hermann Brenner, Emily White, Martha L. Slattery, Edward L. Giovannucci, Jenny Chang‐Claude, Paul D. P. Pharoah, Li Hsu, Peter T. Campbell, Ulrike Peters   +48 more
wiley   +1 more source

Two SNPs (rs1801282 and -1279G/A) of PPARγ are associated with Parkinson's disease in a northern Chinese population

, 2020
Abstract Background: This study aimed to assess the association between PPARγ gene polymorphism and susceptibility to Parkinson’s disease (PD) in a northern Chinese population. Methods : We conducted a case-control study which including 391 outpatients with PD and 391 healthy matched individuals. All subject genotypes on PPARγ gene in rs3856806,
shanshan li, Li Xue, Huimin Wang, Qingwu Tian, Anmu Xie   +4 more
openaire   +1 more source

Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study [PDF]

, 2009
International ...
Delphine D Fradin, M Daniele Fallin
core   +2 more sources

UEG Week 2023 Moderated Posters

, 2023
United European Gastroenterology Journal, Volume 11, Issue S8, Page 201-534, October 2023.
wiley   +1 more source

Peroxisome proliferator-activated receptor γ2 Pro12Ala (rs1801282) polymorphism and breast cancer susceptibility: A meta-analysis

Molecular Medicine Reports, 2013
Several studies have investigated the correlation between the peroxisome proliferator-activated receptor γ2 (PPAR‑γ2) Pro12Ala (rs1801282) polymorphism and the risk of breast cancer, with inconsistent results. For this reason, a meta-analysis was conducted to identify the potential correlation after pooling data from eligible case-control studies ...
Qunxia, Mao, Huilin, Guo, Linggen, Gao, Hongwei, Wang, Xu, Ma   +4 more
openaire   +3 more sources

Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine [PDF]

, 2019
Type 2 diabetes mellitus (T2DM) is a chronic disease that has reached the levels of a global epidemic. In order to achieve optimal glucose control, it is often necessary to rely on combination therapy of multiple drugs or insulin because uncontrolled ...
Andreozzi, F, Mannino, Gc, Sesti, G
core   +1 more source

Population Pharmacokinetic and Pharmacodynamic Analysis of Voriconazole‐Induced Liver Injury in Chinese Lung Transplant Patients

Journal of Clinical Pharmacy and Therapeutics, Volume 2026, Issue 1, 2026.
Background Voriconazole (VCZ) served as primary therapy for invasive aspergillosis in lung transplant recipients. However, VCZ‐induced hepatotoxicity emerged as a frequent adverse effect that critically compromised postoperative management and complication prevention in this vulnerable population.
Dan Zhang, Wenwen Du, Wei Qin, Bo Li, Pengmei Li, Xiaoxing Wang, Wenqian Chen, Anjali Chauhan   +7 more
wiley   +1 more source

Is the rs1801282 (G/C) Polymorphism of PPAR - Gamma Gene Associated with T2DM in Iraqi People?

Open Access Macedonian Journal of Medical Sciences, 2018
BACKGROUND: Pro12Ala (rs1801282) is a common polymorphism of the human PPAR-γ gene. Studies have demonstrated conflicting results about its association with T2DM worldwide. There are no reports about such possible association among Iraqi people. OBJECTIVES:  This study aims at finding out whether having the mutant allele (Ala12) might be associated ...
Al-Naemi, Amjad Hazim, Ahmad, Akram Jarjees   +1 more
openaire   +3 more sources