Worldwide population differentiation at disease-associated SNPs [PDF]
, 2008 Background Recent genome-wide association (GWA) studies have provided compelling evidence of association between genetic variants and common complex diseases.
Sean Myles +64 more
core +2 more sources
Effect of PPAR-γ2 Gene Pro12Ala polymorphism (Rs1801282) and Vitamin D3 on glucose homeostasis in Type 2 diabetic subjects from Gujarat-India [PDF]
Molecular Cytogenetics, 2014 Background Pro12Ala polymorphism in PPAR-g2 gene is known to be involved in insulin sensitization and metabolic deregulation in Type 2 Diabetes (T2D) subject. Considering beneficial effects of Vitamin D3 in functional regulation of pancreatic-b cells, present population based study was designed to determine the association of Pro12Ala polymorphism with
Majumder, Avisek +7 more
openaire +1 more source
Archives of Endocrinology and Metabolism, 2017 Objective Gestational diabetes mellitus (GDM) is a metabolic disorder that shares pathophysiologic features with type 2 diabetes mellitus. The aim of this study was to investigate the association of the polymorphisms fat mass and obesity-associated (FTO)
Mauren Isfer Anghebem-Oliveira +5 more
doaj +1 more source
Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease [PDF]
, 2014 Antitumor necrosis factor-α (TNF-α) is used for treatment of severe cases of inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). However, one-third of the patients do not respond to the treatment.
Andersen, P S +19 more
core +1 more source
Transferability and Fine Mapping of Type 2 Diabetes Loci in African Americans: The Candidate Gene Association Resource Plus Study [PDF]
, 2014 Type 2 diabetes (T2D) disproportionally affects African Americans (AfA) but, to date, genetic variants identified from genome-wide association studies (GWAS) are primarily from European and Asian populations.
Bertoni, Alain G. +24 more
core +1 more source
Patologìâ, 2016 Aim – to study the impact of polymorphic marker rs1801282 of gene PPARG on the formation of oxidative stress in terms of LPO and AOS in patients with type 2 diabetes depending on the duration of the disease. Materials and methods.
V. Y. Mokrii, S. V. Ziablytsev
doaj +1 more source
The PPARγ2 Pro12Ala variant is protective against progression of nephropathy in people with type 2 diabetes [PDF]
, 2015 Cross-sectional studies suggest the association between diabetic nephropathy and the PPARγ2 Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 (PPARγ2).
BRUZZESE, DARIO +7 more
core +1 more source
High-Quality and -Quantity DNA Extraction from Frozen Archival Blood Clots for Genotyping of Single-Nucleotide Polymorphisms [PDF]
, 2013 Background: The recovery of biological samples for genetic epidemiological studies can be cumbersome. Blood clots are routinely collected for serological examinations.
Adkins KK +8 more
core +1 more source
Journal of Diabetes Research, 2015 Background. Transcription factor 7-like 2 gene (TCF7L2) and peroxisome proliferator-activated receptors-γ2 (PPAR-γ2) have a profound effect on the incidence of type 2 diabetes mellitus (T2DM) and had previously been found to be associated with T2DM risk ...
Habiba Al-Safar +5 more
doaj +1 more source
Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus [PDF]
, 2009 Background: Genome-wide association studies (GWAS) have emerged as a powerful approach for identifying susceptibility loci associated with polygenetic diseases such as type 2 diabetes mellitus (T2DM).
Hemang Parikh +2 more
core +3 more sources