Results 11 to 20 of about 26,295 (268)
Association of the FTO Gene With BMI [PDF]
Obesity, 2008 Variants in the FTO gene have been strongly associated with obesity in a very large sample (38,759) of diabetic and control subjects. To replicate these findings, the previously reported SNP in the FTO gene (rs9939609, T/A) was genotyped in 5,607 subjects from five different Utah studies.
Steven C, Hunt +7 more
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Piecing together the FTO jigsaw [PDF]
Genome Biology, 2011 Two recent studies of the FTO gene provide more information on how it affects body mass index.
Frayling, Timothy M, Ong, Ken
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Beilstein Journal of Nanotechnology, 2021 Al2O3 layers were deposited onto electrodes by atomic layer deposition. Solubility and electron-transport blocking were tested. Films deposited onto fluorine-doped tin oxide (FTO, F:SnO2/glass) substrates blocked electron transfer to redox couples ...
Hana Krýsová +5 more
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Molecular Metabolism, 2012 Genome-wide association studies have revealed that SNPs in the first intron of FTO (Fat mass and Obesity related) are robustly associated with body mass index and obesity. Subsequently, it has become clear that this association with body weight, and increasingly food intake, is replicable across multiple populations and different age groups.
Yeo, Giles S.H., O'Rahilly, Stephen
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FTO, RNA epigenetics and epilepsy [PDF]
Epigenetics, 2012 Several recent landmark papers describing N(6) -methyladenosine (m(6) A) RNA modifications have provided valuable new insights as to the importance of m(6) A in the RNA transcriptome and in furthering the understanding of RNA epigenetics. One endogenous enzyme responsible for demethylating RNA m(6) A, FTO, is highly expressed in the CNS and is likely ...
Rowles, Joie +3 more
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Genes and molecules related to obesity and lifestyle-related disease and exercise
Journal of Physical Fitness and Sports Medicine, 2013 In 2006, Rankinen et al. reported 127 candidate obesity-related genes, and since then more have been identified (http://www.genome.gov/gwastudies/). A lot of mutations in more than 7 genes, especially in the MC4-R gene, were reported as monogenic obesity
Masaki Kimura
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Pharmacological Inhibition of FTO
PLOS ONE, 2015 In 2007, a genome wide association study identified a SNP in intron one of the gene encoding human FTO that was associated with increased body mass index. Homozygous risk allele carriers are on average three kg heavier than those homozygous for the protective allele.
Fiona McMurray +12 more
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Food & Nutrition Research, 2022 Background: Fat mass and obesity-associated gene (FTO) is a well-known gene associated with body weight and obesity risk. Recent studies have suggested that genetic variations in FTO may play a role in the regulation of food preference and consumption ...
Young Goh, Jeong-Hwa Choi
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Hypertension in Pregnancy, 2023 Background Preeclampsia (PE) is one of the leading disorders in pregnant women with maternal and fetal complications. Obesity is considered an important risk factor for the development of PE.
Ghasem Azizi-Tabesh +8 more
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Nature Genetics, 2010 Previous genome-wide association studies have identified a strong association between FTO and human obesity, although the mechanism by which FTO affects obesity remains unknown. Anew study suggests that the obesity risk alleles are gain-of-function.
George Stratigopoulos, Rudolph L Leibel
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