Results 11 to 20 of about 114,221 (304)

FTO, obesity and the adolescent brain [PDF]

Human Molecular Genetics, 2012
Genetic variations in fat mass- and obesity (FTO)-associated gene, a well-replicated gene locus of obesity, appear to be associated also with reduced regional brain volumes in elderly. Here, we examined whether FTO is associated with total brain volume in adolescence, thus exploring possible developmental effects of FTO.
Melka, M. G., Gillis, J., Bernard, M., Abrahamowicz, M., Chakravarty, M. M., Leonard, G. T., Perron, M., Richer, L., Veillette, S., Banaschewski, T., Barker, G. J., BüChel, C., Conrod, P., Flor, H., Heinz, A., Garavan, H., Brühl, R., Mann, K., Artiges, E., Lourdusamy, A., Lathrop, M., Loth, E., Schwartz, Y., Frouin, V., Rietschel, M., Smolka, M. N., hle, A., Gallinat, J., Struve, M., Lattka, E., Waldenberger, M., Schumann, G., Pavlidis, P., Gaudet, D., Paus, T., Pausova, Z.   +35 more
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Revealing the catalytic strategy of FTO

Chem Catalysis, 2023
The fat-mass and obesity-associated protein (FTO) is a Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenase of the AlkB family and is linked with obesity and cancer. The enzyme is identified as single-stranded DNA/RNA demethylase with N6-methyladenine (m6A) modification in RNA as its most favorable substrate.
Ann, Varghese, Sodiq O, Waheed, Shobhit S, Chaturvedi, Isabella, DiCastri, Ciara, LaRouche, Brendan, Kaski, Nicolai, Lehnert, Deyu, Li, Christo Z, Christov, Tatyana G, Karabencheva-Christova   +9 more
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FTO polymorphisms in oceanic populations [PDF]

Journal of Human Genetics, 2007
It has been suggested that Neel's "thrifty genotype" model may account for high body weights in some Oceanic populations, which presumably arose in modern times. In European populations, common variants (rs1421085-C, rs17817449-G, and rs9939609-A) in the fat mass and obesity (FTO associated) were recently found to be associated with body mass index ...
Jun, Ohashi, Izumi, Naka, Ryosuke, Kimura, Kazumi, Natsuhara, Taro, Yamauchi, Takuro, Furusawa, Minato, Nakazawa, Yuji, Ataka, Jintana, Patarapotikul, Pornlada, Nuchnoi, Katsushi, Tokunaga, Takafumi, Ishida, Tsukasa, Inaoka, Yasuhiro, Matsumura, Ryutaro, Ohtsuka   +14 more
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Association of the FTO Gene With BMI [PDF]

Obesity, 2008
Variants in the FTO gene have been strongly associated with obesity in a very large sample (38,759) of diabetic and control subjects. To replicate these findings, the previously reported SNP in the FTO gene (rs9939609, T/A) was genotyped in 5,607 subjects from five different Utah studies.
Steven C, Hunt, Steven, Stone, Yuanpei, Xin, Christina A, Scherer, Charles L, Magness, Shawn P, Iadonato, Paul N, Hopkins, Ted D, Adams   +7 more
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Piecing together the FTO jigsaw [PDF]

Genome Biology, 2011
Two recent studies of the FTO gene provide more information on how it affects body mass index.
Frayling, Timothy M, Ong, Ken
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Pharmacological Inhibition of FTO

PLOS ONE, 2015
In 2007, a genome wide association study identified a SNP in intron one of the gene encoding human FTO that was associated with increased body mass index. Homozygous risk allele carriers are on average three kg heavier than those homozygous for the protective allele.
Fiona McMurray, Marina Demetriades, WeiShen Aik, Myrte Merkestein, Holger Kramer, Daniel S Andrew, Cheryl L Scudamore, Tertius A Hough, Sara Wells, Frances M Ashcroft, Michael A McDonough, Christopher J Schofield, Roger D Cox   +12 more
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FTO, RNA epigenetics and epilepsy [PDF]

Epigenetics, 2012
Several recent landmark papers describing N(6) -methyladenosine (m(6) A) RNA modifications have provided valuable new insights as to the importance of m(6) A in the RNA transcriptome and in furthering the understanding of RNA epigenetics. One endogenous enzyme responsible for demethylating RNA m(6) A, FTO, is highly expressed in the CNS and is likely ...
Rowles, Joie, Wong, Morgan, Powers, Ryan, Olsen, Mark   +3 more
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FTO Gene Polymorphisms and Their Roles in Acromegaly

International Journal of Molecular Sciences, 2023
The major causes of both morbidity and mortality in patients with acromegaly are cardiovascular diseases (CVDs). The polymorphisms of the fat mass and obesity-associated gene (FTO) are associated with obesity, as well as with an increased risk of CVDs. The aim of the study was to determine the relationship of risk alleles of four FTO gene polymorphisms
Aleksandra Jawiarczyk-Przybyłowska, Justyna Kuliczkowska-Płaksej, Katarzyna Kolačkov, Agnieszka Zembska, Jowita Halupczok-Żyła, Małgorzata Rolla, Michał Miner, Marcin Kałużny, Marek Bolanowski   +8 more
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Uncovering the biology of FTO

Molecular Metabolism, 2012
Genome-wide association studies have revealed that SNPs in the first intron of FTO (Fat mass and Obesity related) are robustly associated with body mass index and obesity. Subsequently, it has become clear that this association with body weight, and increasingly food intake, is replicable across multiple populations and different age groups.
Yeo, Giles S.H., O'Rahilly, Stephen
openaire   +2 more sources

Detection of Rs9939609 Polymorphism of Fto Gene and Rs324011 Polymorphism of Stat6 Gene and Severity Degree of Bronchial Asthma Associated with Obesity [PDF]

, 2017
The aim of this research was to analyze the distribution of FTO and STAT6 genes polymorphism in patients with bronchial asthma (BA), associated with obesity (Ob) depending on the main disease severity degree.Materials and methods.
Fediv, A. (Alexander), Melnik, E. (Elena)   +1 more
core   +2 more sources