Results 21 to 30 of about 654 (199)
A Non-Heme Iron-Mediated Chemical Demethylation in DNA and RNA [PDF]
Accounts of Chemical Research, 2009 DNA methylation is arguably one of the most important chemical signals in biology. However, aberrant DNA methylation can lead to cytotoxic or mutagenic consequences. A DNA repair protein in Escherichia coli, AlkB, corrects some of the unwanted methylations of DNA bases by a unique oxidative demethylation in which the methyl carbon is liberated as ...
Chengqi, Yi, Cai-Guang, Yang, Chuan, He
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The DEAD-Box RNA Helicase DDX3 Interacts with m6A RNA Demethylase ALKBH5
Stem Cells International, 2017 DDX3 is a member of the family of DEAD-box RNA helicases. DDX3 is a multifaceted helicase and plays essential roles in key biological processes such as cell cycle, stress response, apoptosis, and RNA metabolism.
Abdullah Shah +6 more
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The Complexity of TET2 Functions in Pluripotency and Development
Frontiers in Cell and Developmental Biology, 2021 Ten-eleven translocation-2 (TET2) is a crucial driver of cell fate outcomes in a myriad of biological processes, including embryonic development and tissue homeostasis.
Vera Garcia-Outeiral +3 more
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ALKBH3-dependent m1A demethylation of Aurora A mRNA inhibits ciliogenesis
Cell Discovery, 2022 Primary cilia are antenna-like subcellular structures to act as signaling platforms to regulate many cellular processes and embryonic development. m1A RNA modification plays key roles in RNA metabolism and gene expression; however, the physiological ...
Wenjun Kuang +15 more
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eLife, 2021 Active DNA demethylation has emerged as an important regulatory process of plant and mammalian immunity. However, very little is known about the mechanisms by which active demethylation controls transcriptional immune reprogramming and disease resistance.
Thierry Halter +6 more
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Sequence-specific m6A demethylation in RNA by FTO fused to RCas9 [PDF]
RNA, 2019 N6-methyladenosine (m6A) is the most common internal modification in eukaryotic mRNA and associated with numerous cellular processes in health and disease. Up- and down-regulation of its “writer” or “eraser” proteins alter the global m6A level; however, modifying distinct m6A sites has remained elusive.
Kristina Rau +2 more
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m6A demethylase FTO regulate CTNNB1 to promote adipogenesis of chicken preadipocyte
Journal of Animal Science and Biotechnology, 2022 Background N6-methyladenosine (m6A) is an abundant post-transcriptional RNA modification that affects various biological processes. The fat mass and obesity-associated (FTO) protein, a demethylase encoded by the FTO gene, has been found to regulate ...
Kan Li +3 more
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The histone demethylase Jhdm1a regulates hepatic gluconeogenesis. [PDF]
PLoS Genetics, 2012 Hepatic gluconeogenesis is required for maintaining blood glucose homeostasis; yet, in diabetes mellitus, this process is unrestrained and is a major contributor to fasting hyperglycemia.
Dongning Pan +6 more
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Detailed resume of RNA m6A demethylases
Acta Pharmaceutica Sinica B, 2022 N6-Methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA, playing critical role in various bioprocesses. Like other epigenetic modifications, m6A modification can be catalyzed by the methyltransferase complex and erased ...
Dandan Shen +13 more
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Cell Reports, 2017 This study reveals that high-copy satellite II (HSATII) sequences in the human genome can bind and impact distribution of chromatin regulatory proteins and that this goes awry in cancer.
Lisa L. Hall +7 more
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