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Protein–Protein Interactions in Base Excision Repair [PDF]

Biomolecules
The Base Excision Repair (BER) pathway involves a highly coordinated series of protein–protein interactions that facilitate the recognition, excision, and repair of damaged bases. Key enzymes such as DNA glycosylases, apurinic/apyrimidinic endonuclease 1
Govardhan Rathnaiah, Joann B. Sweasy
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Cancer prognosis using base excision repair genes [PDF]

Molecules and Cells
: The base excision repair (BER) pathway is a critical mechanism in genomic stability. This review investigates the role of the BER pathway in advanced cancer therapies considering the pivotal role of genetic factors in cancer patient responses and ...
Jeongeun Kim, Su-Jin Kang, Nayoon Jo, Seung-Jin Kim, Sunbok Jang   +4 more
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Targeting the 8-oxodG Base Excision Repair Pathway for Cancer Therapy [PDF]

Cells
Genomic integrity is critical for cellular homeostasis, preventing the accumulation of mutations that can drive diseases such as cancer. Among the mechanisms safeguarding genomic stability, the Base Excision Repair (BER) pathway plays a pivotal role in ...
Anna Piscone, Francesca Gorini, Susanna Ambrosio, Anna Noviello, Giovanni Scala, Barbara Majello, Stefano Amente   +6 more
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Dynamic features of human mitochondrial DNA maintenance and transcription

Frontiers in Cell and Developmental Biology, 2022
Mitochondria are the primary sites for cellular energy production and are required for many essential cellular processes. Mitochondrial DNA (mtDNA) is a 16.6 kb circular DNA molecule that encodes only 13 gene products of the approximately 90 different ...
Mansour Akbari, Hilde Loge Nilsen, Hilde Loge Nilsen, Hilde Loge Nilsen, Nicola Pietro Montaldo   +4 more
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Resistance to Nucleotide Excision Repair of Bulky Guanine Adducts Opposite Abasic Sites in DNA Duplexes and Relationships between Structure and Function. [PDF]

PLoS ONE, 2015
The nucleotide excision repair of certain bulky DNA lesions is abrogated in some specific non-canonical DNA base sequence contexts, while the removal of the same lesions by the nucleotide excision repair mechanism is efficient in duplexes in which all ...
Zhi Liu, Shuang Ding, Konstantin Kropachev, Lei Jia, Shantu Amin, Suse Broyde, Nicholas E Geacintov   +6 more
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DNA Repair Repertoire of the Enigmatic Hydra

Frontiers in Genetics, 2021
Since its discovery by Abraham Trembley in 1744, hydra has been a popular research organism. Features like spectacular regeneration capacity, peculiar tissue dynamics, continuous pattern formation, unique evolutionary position, and an apparent lack of ...
Apurva Barve, Apurva Barve, Alisha A. Galande, Saroj S. Ghaskadbi, Surendra Ghaskadbi   +4 more
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OGG1 in Lung—More than Base Excision Repair

Antioxidants, 2022
As the organ executing gas exchange and directly facing the external environment, the lungs are challenged continuously by various stimuli, causing the disequilibration of redox homeostasis and leading to pulmonary diseases.
Xiaodi Ma, Hewei Ming, Lexin Liu, Jiahui Zhu, Lang Pan, Yu Chen, Yang Xiang   +6 more
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Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins

Nature Communications, 2022
Nucleotide excision repair proteins are involved in the repair of UV-induced DNA damage. Here, the authors show that NER proteins, DDB2, XPC, and XPA play a vital role in the 8-oxoguanine repair by coordinating with base excision repair protein OGG1.
Namrata Kumar, Arjan F. Theil, Vera Roginskaya, Yasmin Ali, Michael Calderon, Simon C. Watkins, Ryan P. Barnes, Patricia L. Opresko, Alex Pines, Hannes Lans, Wim Vermeulen, Bennett Van Houten   +11 more
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Cooperation and interplay between base and nucleotide excision repair pathways: From DNA lesions to proteins [PDF]

Genetics and Molecular Biology, 2020
Base and nucleotide excision repair (BER and NER) pathways are normally associated with removal of specific types of DNA damage: small base modifications (such as those induced by DNA oxidation) and bulky DNA lesions (such as those induced by ultraviolet
Namrata Kumar, Natália C. Moreno, Bruno C. Feltes, Carlos FM Menck, Bennett Van Houten   +4 more
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The Role of DNA Damage and Repair in Idiopathic Pulmonary Fibrosis

Antioxidants, 2022
The mortality rate of idiopathic pulmonary fibrosis (IPF) increases yearly due to ineffective treatment. Given that the lung is exposed to the external environment, it is likely that oxidative stress, especially the stimulation of DNA, would be of ...
Jiahui Zhu, Lexin Liu, Xiaodi Ma, Xinyu Cao, Yu Chen, Xiangping Qu, Ming Ji, Huijun Liu, Chi Liu, Xiaoqun Qin, Yang Xiang   +10 more
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