Results 1 to 10 of about 59,918 (258)
Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice
npj Aging and Mechanisms of Disease, 2020 Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan in multiple organisms including mice. CR was shown to enhance base excision repair and nucleotide excision repair pathways of DNA repair, however, whether CR improves
Zhonghe Ke +4 more
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BiomoleculesMitochondrial dysfunction and loss of mitochondrial DNA (mtDNA) integrity are increasingly recognized as key contributors to liver diseases such as cirrhosis and hepatocellular carcinoma.
Carmen M. Pérez-Pérez +6 more
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Initiating base excision repair in chromatin [PDF]
DNA Repair, 2018 The base excision repair (BER) pathway removes modified nucleobases that can be deleterious to an organism. BER is initiated by a glycosylase, which finds and removes these modified nucleobases. Most of the characterization of glycosylase activity has been conducted in the context of DNA oligomer substrates.
Erin E, Kennedy +2 more
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Exploiting Base Excision Repair to Improve Therapeutic Approaches for Pancreatic Cancer
Frontiers in Nutrition, 2015 Pancreatic ductal adenocarcinoma (PDA) is a highly chemoresistant and metastatic disease with a dismal 5-year survival rate of 6%. More effective therapeutic targets and approaches are urgently needed to tackle this devastating disease. The base excision
George eSharbeen +3 more
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Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts.
PLoS ONE, 2015 Bisphenol A (BPA) is a biologically active industrial chemical used in production of consumer products. BPA has become a target of intense public scrutiny following concerns about its association with human diseases such as obesity, diabetes ...
Natalie R Gassman +6 more
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Base excision DNA repair and cancer
Oncotarget, 2014 Transformed cells can develop drug resistance via repair mechanisms that counteract the DNA damage from chemotherapy or radiation therapy. Disruption of DNA repair pathways can cause mis-repair that is cytotoxic [1]. Specific DNA repair inhibitors might thus be combined with DNA-damaging agents for improved therapy.
Tell, G, Demple B
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The relationship between DNA damage and repair and the occurrence and development of disease
Frontiers in GeneticsDNA damage can lead to the development of diseases such as tumors. To counteract this, organisms have evolved various repair mechanisms targeting different types of damage.
Chongbing Sun +4 more
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Overexpression of associated with altered genome and poor survival in selected types of human cancer
Tumor Biology, 2020 Base excision repair, which is initiated by the DNA N -glycosylase proteins, is the frontline for repairing potentially mutagenic DNA base damage. Several base excision repair genes are deregulated in cancer and affect cellular outcomes to chemotherapy ...
Oanh TN Tran +3 more
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Base excision repair in Alzheimer’s disease
Postępy Higieny i Medycyny Doświadczalnej, 2014 Alzheimer's disease (AD) is the most common neurodegenerative disease in people over 65 years of age. Estimates indicate that about 200 thousand Pole suffer from AD while in the world about 30 million people. Forecasts show that in developed countries the number of people with neurodegenerative diseases by 2025 will increase by several hundred percent ...
Dominik, Kwiatkowski, Tomasz, Sliwiński
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Base Excision Repair Gene Polymorphisms and Wilms Tumor Susceptibility
EBioMedicine, 2018 Base excision repair (BER) is the main mechanism to repair endogenous DNA lesions caused by reactive oxygen species. BER deficiency is linked with cancer susceptibility and premature aging.
Jinhong Zhu +6 more
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