Distinct Mechanisms of Target Search by Endonuclease VIII-like DNA Glycosylases [PDF]
Cells, 2022 Proteins that recognize specific DNA sequences or structural elements often find their cognate DNA lesions in a processive mode, in which an enzyme binds DNA non-specifically and then slides along the DNA contour by one-dimensional diffusion. Opposite to
Evgeniia A. Diatlova +2 more
doaj +2 more sources
Geminiviruses employ host DNA glycosylases to subvert DNA methylation-mediated defense [PDF]
Nature Communications, 2022 Plants tightly regulate DNA methylation to regulate gene expression. Here, the authors show that the tomato yellow leaf curl China virus βC1 protein interacts with plant DNA glycosylases to promote demethylation of viral DNA and promote virulence.
Xiaojian Gui +3 more
doaj +2 more sources
Evolutionary Origins of DNA Repair Pathways: Role of Oxygen Catastrophe in the Emergence of DNA Glycosylases [PDF]
Cells, 2021 It was proposed that the last universal common ancestor (LUCA) evolved under high temperatures in an oxygen-free environment, similar to those found in deep-sea vents and on volcanic slopes.
Paulina Prorok +6 more
doaj +2 more sources
DNA glycosylases Ogg1 and Mutyh influence gene expression of PRC2 targets associated with cognition [PDF]
Cellular and Molecular Life SciencesBase excision repair, initiated by DNA glycosylases, preserves genomic integrity by removing damaged bases. DNA glycosylases Ogg1 and Mutyh were shown to alter the hippocampal transcriptome independently of DNA damage repair.
Andreas Abentung +7 more
doaj +2 more sources
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice [PDF]
Communications Biology, 2021 Gunn Hildrestrand, Veslemøy Rolseth, and Nicolas Kunath et al. examine mice lacking the NEIL1 and NEIL2 DNA glycosylases involved in base excision repair.
Gunn A. Hildrestrand +23 more
doaj +2 more sources
Repair of oxidative DNA base damage in the host genome influences the HIV integration site sequence preference. [PDF]
PLoS ONE, 2014 Host base excision repair (BER) proteins that repair oxidative damage enhance HIV infection. These proteins include the oxidative DNA damage glycosylases 8-oxo-guanine DNA glycosylase (OGG1) and mutY homolog (MYH) as well as DNA polymerase beta (Polβ ...
Geoffrey R Bennett +7 more
doaj +10 more sources
Repair of Hypoxanthine in DNA Revealed by DNA Glycosylases and Endonucleases From Hyperthermophilic Archaea [PDF]
Frontiers in Microbiology, 2021 Since hyperthermophilic Archaea (HA) thrive in high-temperature environments, which accelerate the rates of deamination of base in DNA, their genomic stability is facing a severe challenge.
Tan Lin +6 more
doaj +2 more sources
Resistance-Guided Mining of Bacterial Genotoxins Defines a Family of DNA Glycosylases [PDF]
mBio, 2022 Unique DNA repair enzymes that provide self-resistance against therapeutically important, genotoxic natural products have been discovered in bacterial biosynthetic gene clusters (BGCs).
Noah P. Bradley +4 more
doaj +2 more sources
NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress [PDF]
eLife, 2019 Base excision repair (BER) functions not only in the maintenance of genomic integrity but also in active DNA demethylation and epigenetic gene regulation.
Dandan Han +8 more
doaj +2 more sources
No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice [PDF]
Scientific Reports, 2017 Base excision repair (BER) is a major pathway for removal of DNA base lesions and maintenance of genomic stability, which is essential in cancer prevention. DNA glycosylases recognize and remove specific lesions in the first step of BER. The existence of
Veslemøy Rolseth +14 more
doaj +2 more sources