Noncatalytic Domains in DNA Glycosylases [PDF]
International Journal of Molecular Sciences, 2022 Many proteins consist of two or more structural domains: separate parts that have a defined structure and function. For example, in enzymes, the catalytic activity is often localized in a core fragment, while other domains or disordered parts of the same protein participate in a number of regulatory processes.
Evgeniia A Diatlova +2 more
exaly +4 more sources
Inhibitors of DNA Glycosylases as Prospective Drugs [PDF]
International Journal of Molecular Sciences, 2020 DNA glycosylases are enzymes that initiate the base excision repair pathway, a major biochemical process that protects the genomes of all living organisms from intrinsically and environmentally inflicted damage. Recently, base excision repair inhibition proved to be a viable strategy for the therapy of tumors that have lost alternative repair pathways,
Grigory V Mechetin +2 more
exaly +5 more sources
DNA glycosylases search for and remove oxidized DNA bases [PDF]
Environmental and Molecular Mutagenesis, 2013 This review article presents, an overview of the DNA glycosylases that recognize oxidized DNA bases using the Fpg/Nei family of DNA glycosylases as models for how structure can inform function. For example, even though human NEIL1 and the plant and fungal orthologs lack the zinc finger shown to be required for binding, DNA crystal structures revealed a
Susan S Wallace
exaly +5 more sources
Distinct Mechanisms of Target Search by Endonuclease VIII-like DNA Glycosylases [PDF]
Cells, 2022 Proteins that recognize specific DNA sequences or structural elements often find their cognate DNA lesions in a processive mode, in which an enzyme binds DNA non-specifically and then slides along the DNA contour by one-dimensional diffusion. Opposite to
Evgeniia A. Diatlova +2 more
doaj +2 more sources
Geminiviruses employ host DNA glycosylases to subvert DNA methylation-mediated defense [PDF]
Nature Communications, 2022 Plants tightly regulate DNA methylation to regulate gene expression. Here, the authors show that the tomato yellow leaf curl China virus βC1 protein interacts with plant DNA glycosylases to promote demethylation of viral DNA and promote virulence.
Xiaojian Gui +3 more
doaj +2 more sources
Evolutionary Origins of DNA Repair Pathways: Role of Oxygen Catastrophe in the Emergence of DNA Glycosylases [PDF]
Cells, 2021 It was proposed that the last universal common ancestor (LUCA) evolved under high temperatures in an oxygen-free environment, similar to those found in deep-sea vents and on volcanic slopes.
Paulina Prorok +6 more
doaj +2 more sources
DNA glycosylases Ogg1 and Mutyh influence gene expression of PRC2 targets associated with cognition [PDF]
Cellular and Molecular Life SciencesBase excision repair, initiated by DNA glycosylases, preserves genomic integrity by removing damaged bases. DNA glycosylases Ogg1 and Mutyh were shown to alter the hippocampal transcriptome independently of DNA damage repair.
Andreas Abentung +7 more
doaj +2 more sources
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice [PDF]
Communications Biology, 2021 Gunn Hildrestrand, Veslemøy Rolseth, and Nicolas Kunath et al. examine mice lacking the NEIL1 and NEIL2 DNA glycosylases involved in base excision repair.
Gunn A. Hildrestrand +23 more
doaj +2 more sources
Repair of Hypoxanthine in DNA Revealed by DNA Glycosylases and Endonucleases From Hyperthermophilic Archaea [PDF]
Frontiers in Microbiology, 2021 Since hyperthermophilic Archaea (HA) thrive in high-temperature environments, which accelerate the rates of deamination of base in DNA, their genomic stability is facing a severe challenge.
Tan Lin +6 more
doaj +2 more sources
Resistance-Guided Mining of Bacterial Genotoxins Defines a Family of DNA Glycosylases [PDF]
mBio, 2022 Unique DNA repair enzymes that provide self-resistance against therapeutically important, genotoxic natural products have been discovered in bacterial biosynthetic gene clusters (BGCs).
Noah P. Bradley +4 more
doaj +2 more sources