Results 11 to 20 of about 7,033 (174)

Inhibitors of DNA Glycosylases as Prospective Drugs [PDF]

International Journal of Molecular Sciences, 2020
DNA glycosylases are enzymes that initiate the base excision repair pathway, a major biochemical process that protects the genomes of all living organisms from intrinsically and environmentally inflicted damage. Recently, base excision repair inhibition proved to be a viable strategy for the therapy of tumors that have lost alternative repair pathways,
Dmitry Zharkov, Evgeniia Diatlova, Anton Endutkin   +2 more
exaly   +5 more sources

DNA glycosylases search for and remove oxidized DNA bases [PDF]

Environmental and Molecular Mutagenesis, 2013
This review article presents, an overview of the DNA glycosylases that recognize oxidized DNA bases using the Fpg/Nei family of DNA glycosylases as models for how structure can inform function. For example, even though human NEIL1 and the plant and fungal orthologs lack the zinc finger shown to be required for binding, DNA crystal structures revealed a
Susan S Wallace
exaly   +5 more sources

Noncatalytic Domains in DNA Glycosylases. [PDF]

Int J Mol Sci, 2022
Many proteins consist of two or more structural domains: separate parts that have a defined structure and function. For example, in enzymes, the catalytic activity is often localized in a core fragment, while other domains or disordered parts of the same protein participate in a number of regulatory processes.
Torgasheva NA, Diatlova EA, Grin IR, Endutkin AV, Mechetin GV, Vokhtantsev IP, Yudkina AV, Zharkov DO.   +7 more
europepmc   +3 more sources

Impact of Oxidative DNA Damage and the Role of DNA Glycosylases in Neurological Dysfunction [PDF]

International Journal of Molecular Sciences, 2021
Magnar Bjørås, Katja Scheffler, Mirta Mittelstedt Leal DE SOUSA   +2 more
exaly   +2 more sources

DNA Glycosylases Define the Outcome of Endogenous Base Modifications [PDF]

International Journal of Molecular Sciences, 2023
Lisa Lirussi, Hilde Nilsen
exaly   +2 more sources

Novel roles of DNA glycosylases in neurodegenerative diseases and aging [PDF]

Neural Regeneration Research
Vinod Tiwari, Fivos Borbolis, Deborah L. Croteau, Konstantinos Palikaras, Vilhelm A. Bohr   +4 more
doaj   +2 more sources

Focus on DNA Glycosylases—A Set of Tightly Regulated Enzymes with a High Potential as Anticancer Drug Targets [PDF]

International Journal of Molecular Sciences, 2020
Fabienne Hans, Müge Senarisoy, Joanna Timmins   +2 more
exaly   +2 more sources

Computational and Experimental Druggability Assessment of Human DNA Glycosylases [PDF]

ACS Omega, 2019
Maurice Michel, Torkild Visnes, Evert J. Homan, Brinton Seashore-Ludlow, Mattias Hedenström, Elisée Wiita, Karl Vallin, Cynthia B. J. Paulin, Jiaxi Zhang, Olov Wallner, Martin Scobie, Andreas Schmidt, Annika Jenmalm-Jensen, Ulrika Warpman Berglund, Thomas Helleday   +14 more
doaj   +2 more sources

The Biochemical Role of the Human NEIL1 and NEIL3 DNA Glycosylases on Model DNA Replication Forks [PDF]

Genes, 2019
Luciano Mutti, Soran Mohammed, Jason Parsons   +2 more
exaly   +2 more sources

Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites

Nature Communications, 2021
Microbial DNA glycosylases associated with the biosynthesis of DNA-damaging antibiotics have evolved self-resistance for their cognate natural products.
Elwood A. Mullins, Jonathan Dorival, Gong-Li Tang, Dale L. Boger, Brandt F. Eichman   +4 more
doaj   +1 more source