Results 11 to 20 of about 12,279 (184)

Potent pollen gene regulation by DNA glycosylases in maize [PDF]

Nature Communications
Although DNA methylation primarily represses TEs, it also represses select genes that are methylated in plant body tissues but demethylated by DNA glycosylases (DNGs) in endosperm or pollen.
Yibing Zeng, Julian Somers, Harrison S. Bell, Zuzana Vejlupkova, R. Kelly Dawe, John E. Fowler, Brad Nelms, Jonathan I. Gent   +7 more
doaj   +2 more sources

The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure. [PDF]

Sci Rep, 2017
Interstrand cross-links (ICLs) are highly cytotoxic DNA lesions that block DNA replication and transcription by preventing strand separation. Previously, we demonstrated that the bacterial and human DNA glycosylases Nei and NEIL1 excise unhooked ...
Martin PR, Couvé S, Zutterling C, Albelazi MS, Groisman R, Groisman R, Matkarimov BT, Parsons JL, Elder RH, Saparbaev MK.   +9 more
europepmc   +6 more sources

Novel roles of DNA glycosylases in neurodegenerative diseases and aging [PDF]

Neural Regeneration Research
Vinod Tiwari, Fivos Borbolis, Deborah L. Croteau, Konstantinos Palikaras, Vilhelm A. Bohr   +4 more
doaj   +2 more sources

Computational and Experimental Druggability Assessment of Human DNA Glycosylases [PDF]

ACS Omega, 2019
Maurice Michel, Torkild Visnes, Evert J. Homan, Brinton Seashore-Ludlow, Mattias Hedenström, Elisée Wiita, Karl Vallin, Cynthia B. J. Paulin, Jiaxi Zhang, Olov Wallner, Martin Scobie, Andreas Schmidt, Annika Jenmalm-Jensen, Ulrika Warpman Berglund, Thomas Helleday   +14 more
doaj   +2 more sources

Conformational Dynamics of Biopolymers in the Course of Their Interaction: Multifaceted Approaches to the Analysis by the Stopped-Flow Technique with Fluorescence Detection

Photonics, 2023
This review deals with modern approaches to systematic research on molecular-kinetic mechanisms of damage recognition and removal by pro- and eukaryotic enzymes of DNA base excision repair.
Nikita A. Kuznetsov
doaj   +1 more source

Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites

Nature Communications, 2021
Microbial DNA glycosylases associated with the biosynthesis of DNA-damaging antibiotics have evolved self-resistance for their cognate natural products.
Elwood A. Mullins, Jonathan Dorival, Gong-Li Tang, Dale L. Boger, Brandt F. Eichman   +4 more
doaj   +1 more source

A New Family of HEAT-Like Repeat Proteins Lacking a Critical Substrate Recognition Motif Present in Related DNA Glycosylases. [PDF]

PLoS ONE, 2015
DNA glycosylases are important repair enzymes that eliminate a diverse array of aberrant nucleobases from the genomes of all organisms. Individual bacterial species often contain multiple paralogs of a particular glycosylase, yet the molecular and ...
Elwood A Mullins, Rongxin Shi, Lyle A Kotsch, Brandt F Eichman   +3 more
doaj   +1 more source

Inhibition of DNA glycosylases via small molecule purine analogs. [PDF]

PLoS ONE, 2013
Following the formation of oxidatively-induced DNA damage, several DNA glycosylases are required to initiate repair of the base lesions that are formed.
Aaron C Jacobs, Marcus J Calkins, Ajit Jadhav, Dorjbal Dorjsuren, David Maloney, Anton Simeonov, Pawel Jaruga, Miral Dizdaroglu, Amanda K McCullough, R Stephen Lloyd   +9 more
doaj   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Anchored linear oligonucleotides: the effective tool for the real-time measurement of uracil DNA glycosylase activity

Open Biology, 2021
Base excision repair is one of the important DNA repair mechanisms in cells. The fundamental role in this complex process is played by DNA glycosylases.
Anna Ligasová, Ivan Rosenberg, Markéta Bocková, Jiří Homola, Karel Koberna   +4 more
doaj   +1 more source