Results 11 to 20 of about 7,004 (177)

NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress [PDF]

eLife, 2019
Base excision repair (BER) functions not only in the maintenance of genomic integrity but also in active DNA demethylation and epigenetic gene regulation.
Dandan Han, Lars Schomacher, Katrin M Schüle, Medhavi Mallick, Michael U Musheev, Emil Karaulanov, Laura Krebs, Annika von Seggern, Christof Niehrs   +8 more
doaj   +2 more sources

No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice [PDF]

Scientific Reports, 2017
Base excision repair (BER) is a major pathway for removal of DNA base lesions and maintenance of genomic stability, which is essential in cancer prevention. DNA glycosylases recognize and remove specific lesions in the first step of BER. The existence of
Veslemøy Rolseth, Luisa Luna, Ann Karin Olsen, Rajikala Suganthan, Katja Scheffler, Christine G. Neurauter, Ying Esbensen, Anna Kuśnierczyk, Gunn A. Hildrestrand, Anne Graupner, Jill M. Andersen, Geir Slupphaug, Arne Klungland, Hilde Nilsen, Magnar Bjørås   +14 more
doaj   +2 more sources

Potent pollen gene regulation by DNA glycosylases in maize [PDF]

Nature Communications
Although DNA methylation primarily represses TEs, it also represses select genes that are methylated in plant body tissues but demethylated by DNA glycosylases (DNGs) in endosperm or pollen.
Yibing Zeng, Julian Somers, Harrison S. Bell, Zuzana Vejlupkova, R. Kelly Dawe, John E. Fowler, Brad Nelms, Jonathan I. Gent   +7 more
doaj   +2 more sources

Poxvirus uracil-DNA glycosylase-An unusual member of the family I uracil-DNA glycosylases. [PDF]

Protein Sci, 2016
AbstractUracil‐DNA glycosylases are ubiquitous enzymes, which play a key role repairing damages in DNA and in maintaining genomic integrity by catalyzing the first step in the base excision repair pathway. Within the superfamily of uracil‐DNA glycosylases family I enzymes or UNGs are specific for recognizing and removing uracil from DNA.
Schormann N, Zhukovskaya N, Bedwell G, Nuth M, Gillilan R, Prevelige PE, Ricciardi RP, Banerjee S, Chattopadhyay D.   +8 more
europepmc   +4 more sources

DNA Glycosylases Define the Outcome of Endogenous Base Modifications [PDF]

International Journal of Molecular Sciences, 2023
Lisa Lirussi, Hilde Nilsen
exaly   +2 more sources

Impact of Oxidative DNA Damage and the Role of DNA Glycosylases in Neurological Dysfunction [PDF]

International Journal of Molecular Sciences, 2021
Mirta M L Sousa, Jing Ye, Luisa Luna
exaly   +2 more sources

Novel roles of DNA glycosylases in neurodegenerative diseases and aging [PDF]

Neural Regeneration Research
Vinod Tiwari, Fivos Borbolis, Deborah L. Croteau, Konstantinos Palikaras, Vilhelm A. Bohr   +4 more
doaj   +2 more sources

Focus on DNA Glycosylases—A Set of Tightly Regulated Enzymes with a High Potential as Anticancer Drug Targets [PDF]

International Journal of Molecular Sciences, 2020
Fabienne Hans, Müge Senarisoy, Joanna Timmins   +2 more
exaly   +2 more sources

Computational and Experimental Druggability Assessment of Human DNA Glycosylases [PDF]

ACS Omega, 2019
Maurice Michel, Torkild Visnes, Evert J. Homan, Brinton Seashore-Ludlow, Mattias Hedenström, Elisée Wiita, Karl Vallin, Cynthia B. J. Paulin, Jiaxi Zhang, Olov Wallner, Martin Scobie, Andreas Schmidt, Annika Jenmalm-Jensen, Ulrika Warpman Berglund, Thomas Helleday   +14 more
doaj   +2 more sources

Conformational Dynamics of Biopolymers in the Course of Their Interaction: Multifaceted Approaches to the Analysis by the Stopped-Flow Technique with Fluorescence Detection

Photonics, 2023
This review deals with modern approaches to systematic research on molecular-kinetic mechanisms of damage recognition and removal by pro- and eukaryotic enzymes of DNA base excision repair.
Nikita A. Kuznetsov
doaj   +1 more source