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DNA Damage Atlas: an atlas of DNA damage and repair
Nucleic Acids Research, 2023 Abstract DNA damage and its improper repair are the major source of genomic alterations responsible for many human diseases, particularly cancer. To aid researchers in understanding the underlying mechanisms of genome instability, a number of genome-wide profiling approaches have been developed to monitor DNA damage and repair events ...
Yu Liang +9 more
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Cold Spring Harbor Perspectives in Biology, 2010 Structural changes to DNA severely affect its functions, such as replication and transcription, and play a major role in age-related diseases and cancer. A complicated and entangled network of DNA damage response (DDR) mechanisms, including multiple DNA repair pathways, damage tolerance processes, and cell-cycle checkpoints safeguard genomic integrity.
Giglia-Mari, G. +2 more
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Cell Death and Disease, 2022 The Hsp70-binding protein 1 (HspBP1) belongs to a family of co-chaperones that regulate Hsp70 activity and whose biological significance is not well understood.
Cha Kyung Youn +10 more
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Cold Spring Harbor Perspectives in Biology, 2013 Under favorable conditions DNA can survive for thousands of years in the remains of dead organisms. The DNA extracted from such remains is invariably degraded to a small average size by processes that at least partly involve depurination. It also contains large amounts of deaminated cytosine residues that are accumulated toward the ends of the ...
Dabney, J. ; https://orcid.org/0000-0001-8893-1245 +2 more
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Engineering a DNA damage response without DNA damage [PDF]
Genome Biology, 2008 Recent work has achieved the feat of activating the DNA damage checkpoint in the absence of DNA damage, revealing the importance of protein-chromatin associations for the activation, amplification and maintenance of the DNA damage response.
Yeung, ManTek, Durocher, Daniel
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DNA damage and mutation. Types of DNA damage [PDF]
BioDiscovery, 2014 This review outlines the basic types of DNA damage caused by exogenous and endogenous factors, analyses the possible consequences of each type of damage and discusses the need for different types of DNA repair. The mechanisms by which a minor damaging event to DNA may eventually result in the introduction of heritable mutation/s are reviewed. The major
Chakarov, Stoyan +3 more
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Scientific Reports, 2021 In response to UV irradiation, translesion DNA synthesis (TLS) utilizes specialized DNA polymerases to bypass replication-blocking lesions. In a well-established polymerase switch model, Polη is thought to be a preferred TLS polymerase to insert correct ...
Tonghui Bi +3 more
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Lysine Crotonylation: An Emerging Player in DNA Damage Response
Biomolecules, 2022 The DNA damage response (DDR) system plays an important role in maintaining genome stability and preventing related diseases. The DDR network comprises many proteins and posttranslational modifications (PTMs) to proteins, which work in a coordinated ...
Yuqin Zhao +8 more
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DNA Damage and Oxidative DNA Damage in Inflammatory Bowel Disease [PDF]
Journal of Crohn's and Colitis, 2016 Inflammation has long been regarded as a major contributor to cellular oxidative damage and to be involved in the promotion of carcinogenesis.We aimed to investigate the oxidative damage in inflammatory bowel disease [IBD] patients through a case-control and prospective study involving 344 IBD patients and 294 healthy controls. DNA damage and oxidative
Pereira, C +10 more
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Cells, 2021 Clustered DNA lesions (CDL) containing 5′,8-cyclo-2′-deoxypurines (cdPus) are an example of extensive abnormalities occurring in the DNA helix and may impede cellular repair processes.
Julia Kaźmierczak-Barańska +3 more
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