Results 1 to 10 of about 179,307 (119)

Genomic instability as a driver and suppressor of anti-tumor immunity

Frontiers in Immunology
Genomic instability is a driver and accelerator of tumorigenesis and influences disease outcomes across cancer types. Although genomic instability has been associated with immune evasion and worsened disease prognosis, emerging evidence shows that ...
Marta Requesens, Floris Foijer, Hans W. Nijman, Marco de Bruyn   +3 more
doaj   +3 more sources

Pol32, an accessory subunit of DNA polymerase delta, plays an essential role in genome stability and pathogenesis of Candida albicans

Gut Microbes, 2023
Candida albicans is a pathobiont that inflicts serious bloodstream fungal infections in individuals with compromised immunity and gut dysbiosis. Genomic diversity in the form of copy number alteration, ploidy variation, and loss of heterozygosity as an ...
Shraddheya Kumar Patel, Satya Ranjan Sahu, Bhabasha Gyanadeep Utkalaja, Swagata Bose, Narottam Acharya   +4 more
doaj   +1 more source

Commensal Fungus Candida albicans Maintains a Long-Term Mutualistic Relationship with the Host To Modulate Gut Microbiota and Metabolism

Microbiology Spectrum, 2022
Candida albicans survives as a commensal fungus in the gastrointestinal tract, and that its excessive growth causes infections in immunosuppressed individuals is widely accepted. However, any mutualistic relationship that may exist between C.
Doureradjou Peroumal, Satya Ranjan Sahu, Premlata Kumari, Bhabasha Gyanadeep Utkalaja, Narottam Acharya   +4 more
doaj   +1 more source

Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7‐deficient cells

EMBO Molecular Medicine, 2022
FBXW7 is one of the most frequently mutated tumor suppressors, deficiency of which has been associated with resistance to some anticancer therapies. Through bioinformatics and genome‐wide CRISPR screens, we here reveal that FBXW7 deficiency leads to ...
Laura Sanchez‐Burgos, Belén Navarro‐González, Santiago García‐Martín, Oleksandra Sirozh, Jorge Mota‐Pino, Elena Fueyo‐Marcos, Héctor Tejero, Marta Elena Antón, Matilde Murga, Fátima Al‐Shahrour, Oscar Fernandez‐Capetillo   +10 more
doaj   +1 more source

4-nitroquinoline 1-oxide induces immune cells death to onset early immunosuppression during oral squamous cell carcinoma development

Frontiers in Immunology, 2023
4-Nitroquinoline N-oxide (4-NQO) and its derivatives react with genomic DNA to form stable quinolone monoadducts, which are highly mutagenic and genotoxic.
Satya Ranjan Sahu, Satya Ranjan Sahu, Shweta Thakur, Doureradjou Peroumal, Bhabasha Gyanadeep Utkalaja, Bhabasha Gyanadeep Utkalaja, Abinash Dutta, Premlata Kumari, Premlata Kumari, Ipsita Subhadarsini, Ipsita Subhadarsini, Narottam Acharya   +11 more
doaj   +1 more source

Spot Assay and Colony Forming Unit (CFU) Analyses–based sensitivity test for Candida albicans and Saccharomyces cerevisiae

Bio-Protocol, 2023
Cellular sensitivity is an approach to inhibit the growth of certain cells in response to any non-permissible conditions, as the presence of a cytotoxic agent or due to changes in growth parameters such as temperature, salt, or media components ...
Satya Sahu, Bhabasha Utkalaja, Shraddheya Patel, Narottam Acahrya   +3 more
doaj   +1 more source

Cell Cycle Analysis of Candida albicans by Flow Cytometry

Bio-Protocol, 2023
The cell cycle is a vital process of cell division that is required to sustain life. Since faithful cell division is critical for the proper growth and development of an organism, the study of the cell cycle becomes a fundamental research objective ...
Shraddheya Patel, Satya Sahu, Narottam Acahrya   +2 more
doaj   +1 more source

Vaccines against candidiasis: Status, challenges and emerging opportunity

Frontiers in Cellular and Infection Microbiology, 2022
Candidiasis is a mycosis caused by opportunistic Candida species. The occurrence of fungal infections has considerably increased in the last few years primarily due to an increase in the number of immune-suppressed individuals.
Satya Ranjan Sahu, Satya Ranjan Sahu, Swagata Bose, Swagata Bose, Manish Singh, Premlata Kumari, Premlata Kumari, Abinash Dutta, Bhabasha Gyanadeep Utkalaja, Bhabasha Gyanadeep Utkalaja, Shraddheya Kumar Patel, Shraddheya Kumar Patel, Narottam Acharya   +12 more
doaj   +1 more source

MicroRNA-145 Impairs Classical Non-Homologous End-Joining in Response to Ionizing Radiation-Induced DNA Double-Strand Breaks via Targeting DNA-PKcs

Cells, 2022
DNA double-strand breaks (DSBs) are one of the most lethal types of DNA damage due to the fact that unrepaired or mis-repaired DSBs lead to genomic instability or chromosomal aberrations, thereby causing cell death or tumorigenesis.
Muddenahalli Srinivasa Sudhanva, Gurusamy Hariharasudhan, Semo Jun, Gwanwoo Seo, Radhakrishnan Kamalakannan, Hyun Hee Kim, Jung-Hee Lee   +6 more
doaj   +1 more source

CtIP Regulates Mitotic Spindle Assembly by Modulating the TPX2-Aurora A Signaling Axis

Cells, 2022
CtBP-interacting protein (CtIP) plays a critical role in controlling the homologous recombination-mediated DNA double-stranded break (DSB) repair pathway through DNA end resection, and recent studies suggest that it also plays a role in mitosis. However,
Wonkyung Oh, Ting Ting Wu, Seo-Yeon Jeong, Ho Jin You, Jung-Hee Lee   +4 more
doaj   +1 more source