Results 1 to 10 of about 184,862 (303)

Genomic instability — the engine of tumorigenesis?

Nature Reviews Cancer, 2003
Human cancers harbour numerous mutations and it has been proposed that these result from some form of inherent genomic instability. Some cancers have proven genomic instability or features that are indicative of this. Inherited cancer syndromes exist that are caused by deficient DNA repair or chromosomal integrity. By contrast, theoretical analysis and
Oliver M Sieber, Karl Heinimann, Sieber Oliver M   +2 more
exaly   +5 more sources

Editorial: Genomic Instability and Neurodegeneration [PDF]

Frontiers in Aging Neuroscience, 2022
No abstract ...
Julia Fuchs, Bjoern Schwer, Bjoern Schwer, Bjoern Schwer, Bjoern Schwer, Sherif F. El-Khamisy, Sherif F. El-Khamisy   +6 more
doaj   +5 more sources

Energetics of whole genome doubling and genomic instability. [PDF]

Cancer Lett
Whole genome doubling (WGD) is among the most prevalent genomic alterations in cancer, present in approximately one third of patients at the time of diagnosis. WGD provides cancer cells with a selective advantage, by protecting against mutations in haploinsufficient genes or buffering deleterious mutations.
Beck RJ, Tagal V, Amin S, Bakhoum SF, Maley CC, Verhaak RGW, Gomes AP, Andor N.   +7 more
europepmc   +4 more sources

Genomic instability as a driver and suppressor of anti-tumor immunity

Frontiers in Immunology
Genomic instability is a driver and accelerator of tumorigenesis and influences disease outcomes across cancer types. Although genomic instability has been associated with immune evasion and worsened disease prognosis, emerging evidence shows that ...
Marta Requesens, Floris Foijer, Hans W. Nijman, Marco de Bruyn   +3 more
doaj   +3 more sources

Pol32, an accessory subunit of DNA polymerase delta, plays an essential role in genome stability and pathogenesis of Candida albicans

Gut Microbes, 2023
Candida albicans is a pathobiont that inflicts serious bloodstream fungal infections in individuals with compromised immunity and gut dysbiosis. Genomic diversity in the form of copy number alteration, ploidy variation, and loss of heterozygosity as an ...
Shraddheya Kumar Patel, Satya Ranjan Sahu, Bhabasha Gyanadeep Utkalaja, Swagata Bose, Narottam Acharya   +4 more
doaj   +1 more source

Commensal Fungus Candida albicans Maintains a Long-Term Mutualistic Relationship with the Host To Modulate Gut Microbiota and Metabolism

Microbiology Spectrum, 2022
Candida albicans survives as a commensal fungus in the gastrointestinal tract, and that its excessive growth causes infections in immunosuppressed individuals is widely accepted. However, any mutualistic relationship that may exist between C.
Doureradjou Peroumal, Satya Ranjan Sahu, Premlata Kumari, Bhabasha Gyanadeep Utkalaja, Narottam Acharya   +4 more
doaj   +1 more source

Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7‐deficient cells

EMBO Molecular Medicine, 2022
FBXW7 is one of the most frequently mutated tumor suppressors, deficiency of which has been associated with resistance to some anticancer therapies. Through bioinformatics and genome‐wide CRISPR screens, we here reveal that FBXW7 deficiency leads to ...
Laura Sanchez‐Burgos, Belén Navarro‐González, Santiago García‐Martín, Oleksandra Sirozh, Jorge Mota‐Pino, Elena Fueyo‐Marcos, Héctor Tejero, Marta Elena Antón, Matilde Murga, Fátima Al‐Shahrour, Oscar Fernandez‐Capetillo   +10 more
doaj   +1 more source

4-nitroquinoline 1-oxide induces immune cells death to onset early immunosuppression during oral squamous cell carcinoma development

Frontiers in Immunology, 2023
4-Nitroquinoline N-oxide (4-NQO) and its derivatives react with genomic DNA to form stable quinolone monoadducts, which are highly mutagenic and genotoxic.
Satya Ranjan Sahu, Satya Ranjan Sahu, Shweta Thakur, Doureradjou Peroumal, Bhabasha Gyanadeep Utkalaja, Bhabasha Gyanadeep Utkalaja, Abinash Dutta, Premlata Kumari, Premlata Kumari, Ipsita Subhadarsini, Ipsita Subhadarsini, Narottam Acharya   +11 more
doaj   +1 more source

Genome Instability and γH2AX [PDF]

International Journal of Molecular Sciences, 2017
γH2AX has emerged in the last 20 years as a central player in the DDR (DNA damage response), with specificity for DSBs (double-strand breaks). Upon the generation of DSBs, γ-phosphorylation extends along megabase-long domains in chromatin, both sides of the damage.
Georgoulis, A., Vorgias, C.E., Chrousos, G.P., Rogakou, E.P.   +3 more
openaire   +3 more sources

Bacterial Genome Instability [PDF]

Microbiology and Molecular Biology Reviews, 2014
SUMMARY Bacterial genomes are remarkably stable from one generation to the next but are plastic on an evolutionary time scale, substantially shaped by horizontal gene transfer, genome rearrangement, and the activities of mobile DNA elements. This implies the existence of a delicate balance between the maintenance of genome stability and the ...
Elise, Darmon, David R F, Leach
openaire   +2 more sources