Results 31 to 40 of about 184,862 (303)
Cell Death and Disease, 2021 Abstrct Ephexin1 was reported to be highly upregulated by oncogenic Ras, but the functional consequences of this remain poorly understood. Here, we show that Ephexin1 is highly expressed in colorectal cancer (CRC) and lung cancer (LC) patient tissues ...
Jeeho Kim +6 more
doaj +1 more source
Transcription–Replication Coordination
Life, 2022 Transcription and replication are the two most essential processes that a cell does with its DNA: they allow cells to express the genomic content that is required for their functions and to create a perfect copy of this genomic information to pass on to ...
Marco Saponaro
doaj +1 more source
Targeting ATR and Chk1 kinases for cancer treatment: A new model for new (and old) drugs
Molecular Oncology, 2011 Trying to kill cancer cells by generating DNA damage is by no means a new idea. Radiotherapy and genotoxic drugs are routinely used in cancer therapy.
Luis I. Toledo +2 more
doaj +1 more source
Lab-made 3D printed stoppers as high-throughput cell migration screening tool
SLAS Technology, 2022 Cell migration is a process that underlies the development and maintenance of multicellular organisms, with profound implications in various pathologies.
Silvina Acosta +4 more
doaj +1 more source
SCARA3 inhibits cell proliferation and EMT through AKT signaling pathway in lung cancer
BMC Cancer, 2022 Background Scavenger receptor class A member 3 (SCARA3) is decreased in prostate cancer and myeloma. However, functions of SCARA3 in various cancers remain unclear.
Jeeho Kim, Ho Jin You, Chakyung Youn
doaj +1 more source
AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation
Life Science Alliance, 2021 This work reveals a novel function of WWP1 E3 ligase in the mono-ubiquitination of AMOTL2, which enables the binding and activation of LATS kinases upon contact inhibition.
Daehee Hwang +7 more
doaj +1 more source
ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability
Nature Communications, 2017 MDC1 is a key component of the DNA damage response and interacts with several factors such as γ-H2AX. Here the authors show that MDC1 interacts with ID3, facilitating MDC1 recruitment to sites of damage and repair of breaks.
Jung-Hee Lee +11 more
doaj +1 more source
Current Oncology, 2022 Genomic instability facilitates the evolution of cells, tissues, organs, and species. The progression of human malignancies can be regarded as the accumulation of genomic instability, which confers a high evolutionary potential for tumor cells to adapt ...
Xue Liu +11 more
doaj +1 more source
Nature Communications, 2018 This Article contains errors in Fig. 3, Fig. 4 and Fig. 7, for which we apologize. In Fig. 3, panel ‘b’, the 0.5 hour time point after Ku55933 treatment images were inadvertently replaced with duplicates of the 3 hour time point after Ku55933 treatment ...
Jung-Hee Lee +11 more
doaj +1 more source
The Dynamic Instability of the Aneuploid Genome [PDF]
Frontiers in Cell and Developmental Biology, 2022 Proper partitioning of replicated sister chromatids at each mitosis is crucial for maintaining cell homeostasis. Errors in this process lead to aneuploidy, a condition in which daughter cells harbor genome imbalances. Importantly, aneuploid cells often experience DNA damage, which in turn could drive genome instability. This might be the product of DNA
Lorenza Garribba +2 more
openaire +4 more sources