Results 41 to 50 of about 1,126,913 (153)

Early lesions of follicular lymphoma: a genetic perspective

Haematologica, 2014
The pathogenesis of follicular lymphoma is a multi-hit process progressing over many years through the accumulation of numerous genetic alterations. Besides the hallmark t(14;18), it is still unclear which other oncogenic hits contribute to the early ...
Emilie Mamessier, Joo Y. Song, Franziska C. Eberle, Svetlana Pack, Charlotte Drevet, Bruno Chetaille, Ziedulla Abdullaev, José Adelaïde, Daniel Birnbaum, Max Chaffanet, Stefania Pittaluga, Sandrine Roulland, Andreas Chott, Elaine S. Jaffe, Bertrand Nadel   +14 more
doaj   +1 more source

Ectopically Expressed Meiosis-Specific Cancer Testis Antigen HORMAD1 Promotes Genomic Instability in Squamous Cell Carcinomas

Cells, 2023
Genomic instability is a prominent hallmark of cancer, however the mechanisms that drive and sustain this process remain elusive. Research demonstrates that numerous cancers with increased levels of genomic instability ectopically express meiosis ...
Jennifer Gantchev, Julia Messina-Pacheco, Amelia Martínez Villarreal, Brandon Ramchatesingh, Philippe Lefrançois, Pingxing Xie, Laetitia Amar, Hong Hao Xu, Keerthenan Raveendra, Daniel Sikorski, Daniel Josue Guerra Ordaz, Raman Preet Kaur Gill, Marine Lambert, Ivan V. Litvinov   +13 more
doaj   +1 more source

Hsp90-Mediated Multi-Drug Resistance in DNA Polymerase-Defective Strains of Candida albicans

Journal of Fungi
The incidence of infections caused by Candida species, specifically by drug-resistant isolates, is a major health concern as they can disseminate to and colonize most vital organs, enhancing morbidity and mortality. Several molecular mechanisms have been
Bhabasha Gyanadeep Utkalaja, Satya Ranjan Sahu, Sushree Subhashree Parida, Narottam Acharya   +3 more
doaj   +1 more source

SATB1, genomic instability and Gleason grading constitute a novel risk score for prostate cancer

Scientific Reports, 2021
Current prostate cancer risk classifications rely on clinicopathological parameters resulting in uncertainties for prognostication. To improve individual risk stratification, we examined the predictive value of selected proteins with respect to tumor ...
Christoph Dumke, Timo Gemoll, Martina Oberländer, Sandra Freitag-Wolf, Christoph Thorns, Axel Glaessgen, Rinse Klooster, Silvère M. van der Maarel, Jerker Widengren, Christian Doehn, Gert Auer, Jens K. Habermann   +11 more
doaj   +1 more source

Sequencing data: A genomic network to monitor Earth

, 2012
We propose that a network of genomic observatories should be established to take the planet's 'biological pulse'. We invite participants to assist in the shaping of this network (see genomicobservatories.org).
Field, D., The Genomic Observatories Network, Neil Davies, Hirsch, P. R., The Genomic Observatories Network, ., The Genomic Observatories Network,, Davies, N., Field, Dawn, Bates, N., Dawn Field, Davies, Neil   +10 more
core   +1 more source

Replicative Instability Drives Cancer Progression

Biomolecules, 2022
In the past decade, defective DNA repair has been increasingly linked with cancer progression. Human tumors with markers of defective DNA repair and increased replication stress exhibit genomic instability and poor survival rates across tumor types ...
Benjamin B. Morris, Jason P. Smith, Qi Zhang, Zhijie Jiang, Oliver A. Hampton, Michelle L. Churchman, Susanne M. Arnold, Dwight H. Owen, Jhanelle E. Gray, Patrick M. Dillon, Hatem H. Soliman, Daniel G. Stover, Howard Colman, Arnab Chakravarti, Kenneth H. Shain, Ariosto S. Silva, John L. Villano, Michael A. Vogelbaum, Virginia F. Borges, Wallace L. Akerley, Ryan D. Gentzler, Richard D. Hall, Cindy B. Matsen, C. M. Ulrich, Andrew R. Post, David A. Nix, Eric A. Singer, James M. Larner, Peter Todd Stukenberg, David R. Jones, Marty W. Mayo   +30 more
doaj   +1 more source

The Presence of Genomic Instability in Cerebrospinal Fluid in Patients with Meningeal Metastasis

, 2021
Peng Wang,1,2,* Henghui Zhang,3 Peng Chen,3 Zengfeng Sun,1,2 Zhen Zhang,1,2 Qiang Yin,1,2 Huaibo Sun,3 Jinpu Yu2,4,* 1Department of Neuro-Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer ...
Wang P, Chen P, Zhang Z, Zhang H, Yin Q, Sun H, Yu J, Sun Z   +7 more
core  

RECQL5 Suppresses Oncogenic JAK2-Induced Replication Stress and Genomic Instability [PDF]

, 2015
JAK2V617F is the most common oncogenic lesion in patients with myeloproliferative neoplasms (MPNs). Despite the ability of JAK2V617F to instigate DNA damage in vitro, MPNs are nevertheless characterized by genomic stability.
Breyfogle, L.J., DeAngelo, D.J., Chen, Edwin, Edwin Chen, Green, Anthony R., Edwin Chen, Breyfogle, LJ, Mullaly, A, Ahn, JS, Mullally, A., DeAngelo, Daniel J., Anthony R. Green, Nangalia, J., Ahn, Jong Sook, Chen, E, Nangalia, J, Ahn, J.S., Mullally, Ann, Chen, E., Green, AR, Nangalia, Jyoti, Green, A.R., Ko, A, Lawrence J. Breyfogle, Sykes, DB, Sykes, David B., Ann Mullally, Daniel J. DeAngelo, Ko, A., DeAngelo, DJ, Sykes, D.B., Godfrey, AL, Ko, Amy, Jong Sook Ahn, David B. Sykes, Godfrey, A.L., Amy Ko, Godfrey, Anna L., Breyfogle, Lawrence J., Anna L. Godfrey, Jyoti Nangalia   +40 more
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TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage

Nature Communications, 2016
Recruiting DNA damage repair factors to the sites of DNA damage is critical for the maintenance of genome integrity. Here the authors identify that the TRAF-interacting protein (TRAIP/RNF206) is required for normal recruitment of RAP80 to DNA lesions and
Nam Soo Lee, Hee Jin Chung, Hyoung-June Kim, Seo Yun Lee, Jae-Hoon Ji, Yoojeong Seo, Seung Hun Han, Minji Choi, Miyong Yun, Seok-Geun Lee, Kyungjae Myung, Yonghwan Kim, Ho Chul Kang, Hongtae Kim   +13 more
doaj   +1 more source

ATR is required to complete meiotic recombination in mice

Nature Communications, 2018
ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a hypomorphic Atr mutation and chemical inhibition, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and ...
Sarai Pacheco, Andros Maldonado-Linares, Marina Marcet-Ortega, Cristina Rojas, Ana Martínez-Marchal, Judit Fuentes-Lazaro, Julian Lange, Maria Jasin, Scott Keeney, Oscar Fernández-Capetillo, Montserrat Garcia-Caldés, Ignasi Roig   +11 more
doaj   +1 more source