Results 41 to 50 of about 184,862 (303)

RECQL5 Suppresses Oncogenic JAK2-Induced Replication Stress and Genomic Instability [PDF]

, 2015
JAK2V617F is the most common oncogenic lesion in patients with myeloproliferative neoplasms (MPNs). Despite the ability of JAK2V617F to instigate DNA damage in vitro, MPNs are nevertheless characterized by genomic stability.
Breyfogle, L.J., DeAngelo, D.J., Chen, Edwin, Edwin Chen, Green, Anthony R., Edwin Chen, Breyfogle, LJ, Mullaly, A, Ahn, JS, Mullally, A., DeAngelo, Daniel J., Anthony R. Green, Nangalia, J., Ahn, Jong Sook, Chen, E, Nangalia, J, Ahn, J.S., Mullally, Ann, Chen, E., Green, AR, Nangalia, Jyoti, Green, A.R., Ko, A, Lawrence J. Breyfogle, Sykes, DB, Sykes, David B., Ann Mullally, Daniel J. DeAngelo, Ko, A., DeAngelo, DJ, Sykes, D.B., Godfrey, AL, Ko, Amy, Jong Sook Ahn, David B. Sykes, Godfrey, A.L., Amy Ko, Godfrey, Anna L., Breyfogle, Lawrence J., Anna L. Godfrey, Jyoti Nangalia   +40 more
core   +1 more source

A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells

Cell Reports, 2019
Summary: The recent availability of somatic haploid cell lines has provided a unique tool for genetic studies in mammals. However, the percentage of haploid cells rapidly decreases in these cell lines, which we recently showed is due to their overgrowth ...
Teresa Olbrich, Maria Vega-Sendino, Matilde Murga, Guillermo de Carcer, Marcos Malumbres, Sagrario Ortega, Sergio Ruiz, Oscar Fernandez-Capetillo   +7 more
doaj   +1 more source

Clinical consequences of BRCA2 hypomorphism

npj Breast Cancer, 2021
The tumor suppressor FANCD1/BRCA2 is crucial for DNA homologous recombination repair (HRR). BRCA2 biallelic pathogenic variants result in a severe form of Fanconi anemia (FA) syndrome, whereas monoallelic pathogenic variants cause mainly hereditary ...
Laia Castells-Roca, Sara Gutiérrez-Enríquez, Sandra Bonache, Massimo Bogliolo, Estela Carrasco, Miriam Aza-Carmona, Gemma Montalban, Núria Muñoz-Subirana, Roser Pujol, Cristina Cruz, Alba Llop-Guevara, María J. Ramírez, Cristina Saura, Adriana Lasa, Violeta Serra, Orland Diez, Judith Balmaña, Jordi Surrallés   +17 more
doaj   +1 more source

Mutation-Derived Long Noncoding RNA Signature Predicts Survival in Lung Adenocarcinoma

Frontiers in Oncology, 2022
BackgroundGenomic instability is one of the representative features of cancer evolution. Recent research has revealed that long noncoding RNAs (lncRNAs) play a critical role in maintaining genomic instability. Our work proposed a gene signature (GILncSig)
Longjun Yang, Longjun Yang, Guangran Guo, Guangran Guo, Xiangyang Yu, Yingsheng Wen, Yingsheng Wen, Yongbin Lin, Yongbin Lin, Rusi Zhang, Rusi Zhang, Dechang Zhao, Dechang Zhao, Zirui Huang, Zirui Huang, Gongming Wang, Gongming Wang, Yan Yan, Yan Yan, Xuewen Zhang, Xuewen Zhang, Dongtai Chen, Dongtai Chen, Wei Xing, Wei Xing, Weidong Wang, Weian Zeng, Weian Zeng, Lanjun Zhang, Lanjun Zhang   +29 more
doaj   +1 more source

Genomic instability is associated with natural life span variation in Saccharomyces cerevisiae. [PDF]

PLoS ONE, 2008
Increasing genomic instability is associated with aging in eukaryotes, but the connection between genomic instability and natural variation in life span is unknown. We have quantified chronological life span and loss-of-heterozygosity (LOH) in 11 natural
Hong Qin, Meng Lu, David S Goldfarb
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Diploid-specific genome stability genes of S. cerevisiae: genomic screen reveals haploidization as an escape from persisting DNA rearrangement stress. [PDF]

, 2011
Maintaining a stable genome is one of the most important tasks of every living cell and the mechanisms ensuring it are similar in all of them. The events leading to changes in DNA sequence (mutations) in diploid cells occur one to two orders of magnitude
Skoneczna, Adrianna, Malgorzata Alabrudzinska, Marek Skoneczny, Alabrudzinska Malgorzata, Skoneczna Adrianna, Skoneczny Marek, Alabrudzinska, Malgorzata, Skoneczny, Marek, Adrianna Skoneczna   +8 more
core   +1 more source

Disruption of the β-catenin destruction complex via Ephexin1-Axin1 interaction promotes colorectal cancer proliferation

Experimental and Molecular Medicine
Wnt signaling is essential for cell growth and tumor formation and is abnormally activated in colorectal cancer (CRC), contributing to tumor progression; however, the specific role and regulatory mechanisms involved in tumor development remain unclear ...
Jeeho Kim, Young Jin Jeon, In-Youb Chang, Jung-Hee Lee, Ho Jin You   +4 more
doaj   +1 more source

Tumor Hypoxia Drives Genomic Instability

Frontiers in Cell and Developmental Biology, 2021
Cancer is a leading cause of death worldwide. As a common characteristic of cancer, hypoxia is associated with poor prognosis due to enhanced tumor malignancy and therapeutic resistance.
Ming Tang, Ming Tang, Emma Bolderson, Emma Bolderson, Kenneth J. O’Byrne, Kenneth J. O’Byrne, Kenneth J. O’Byrne, Derek J. Richard, Derek J. Richard   +8 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source