Results 61 to 70 of about 1,126,913 (153)

Nuclear TRADD prevents DNA damage-mediated death by facilitating non-homologous end-joining repair

Scientific Reports, 2017
TNF receptor-associated death domain (TRADD) is an essential mediator of TNF receptor signaling, and serves as an adaptor to recruit other effectors. TRADD has been shown to cycle between the cytoplasm and nucleus due to its nuclear localization (NLS ...
Gi-Bang Koo, Jae-Hoon Ji, Hyeseong Cho, Michael J. Morgan, You-Sun Kim   +4 more
doaj   +1 more source

Genomic instability and colon carcinogenesis: from the perspective of genes

Frontiers in Oncology, 2013
Colon cancer is the second most lethal cancer; approximately 600,000 people die of it annually in the world. Colon carcinogenesis generally follows a slow and stepwise process of accumulation of mutations under the influence of environmental and ...
Chinthalapally V Rao, Hiroshi Y Yamada
doaj   +1 more source

Genomic instability--the engine of tumorigenesis?

, 2003
Human cancers harbour numerous mutations and it has been proposed that these result from some form of inherent genomic instability. Some cancers have proven genomic instability or features that are indicative of this.
Tomlinson, IP, Karl Heinimann, Ian P. M. Tomlinson, Sieber, OM, Heinimann, K, Oliver M. Sieber   +5 more
core   +1 more source

Hydrophobic bile acids, genomic instability, Darwinian selection, and colon carcinogenesis

, 2008
Claire M Payne, Carol Bernstein, Katerina Dvorak, Harris BernsteinDepartment of Cell Biology and Anatomy, College of Medicine, University of Arizona, Tucson, Arizona, USAAbstract: Sporadic colon cancer is caused predominantly by dietary factors.
Harris Bernstein, Katerina Dvorak, Claire M Payne, Carol Bernstein   +3 more
core  

Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining. [PDF]

, 2015
Deficiencies in DNA double-strand break (DSB) repair lead to genetic instability, a recognized cause of cancer initiation and evolution. We report that the retinoblastoma tumor suppressor protein (RB1) is required for DNA DSB repair by canonical non ...
Spanswick, VJ, Maciej T. Luczynski, Rieger, Simone, Luczynski, Maciej T., Cook, Rebecca, Cook, R, Hartley, JA, Paul H. Huang, Victoria J. Spanswick, Huang, Paul H., Hartley, John A., John A. Hartley, Luczynski, MT, Rieger, S, Mittnacht, Sibylle, Mittnacht, S, Spanswick, Victoria J., Moquet, J, Huang, PH, Kai Rothkamm, Zoumpoulidou, Georgia, Jayne Moquet, Zoumpoulidou, G, Georgia Zoumpoulidou, Simone Rieger, Sibylle Mittnacht, Rothkamm, K, Rebecca Cook, Moquet, Jayne, Rothkamm, Kai   +29 more
core   +1 more source

Emerging concepts in drug discovery for cancer therapy

Molecular Oncology, 2022
Matilde Murga, Oscar Fernandez‐Capetillo   +1 more
doaj   +1 more source

Fingerprinting genomic instability in oral submucous fibrosis

, 2008
Background: Oral submucous fibrosis (OSF) is a high-risk pre-cancerous condition where 7-13% of these patients develop head and neck squamous cell carcinoma (HNSCC). To date there is no cancer predictive markers for OSF patients.
G. Pitiyage, A. Lalli, W. M. Tilakaratne, A. Ariyawardana, Stewart, J.E., J. E. Stewart, E. Hagi-Pavli, A. Waseem, F. Fortune, Teh, M.T., Fortune, F., Tilakaratne, W.M., Waseem, A., B. D. Young, M. T. Teh, Pitiyage, G., Young, B.D., T. Chaplin, Chaplin, T., Cruchley, A., A. Cruchley, Ariyawardana, A., Hagi-Pavli, E., Lalli, A.   +23 more
core   +1 more source

Understanding genomic instability induced by telomere shortering

, 2021
International audienceTelomeres protect chromosomes from fusion and degradations, but this function is threatened in human somatic cells where telomeres are progressively shortened after successive cell divisions in the absence of telomerase activity ...
Casier, Karine, Teixeira, Maria Teresa
core   +2 more sources

Genomic instability in obesity-associated colon cancer

, 2014
Epidemiological studies have demonstrated the association between obesity and colon cancer. Many studies using animal models have also confirmed that obesity increases colon cancer incidence.
Chen, Jiezhong, Ling, Ming-Tat, Shao, R, Shao, Renfu   +3 more
core   +1 more source

CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination.

PLoS Genetics, 2008
At least 25 inherited disorders in humans result from microsatellite repeat expansion. Dramatic variation in repeat instability occurs at different disease loci and between different tissues; however, cis-elements and trans-factors regulating the ...
Randell T Libby, Katharine A Hagerman, Victor V Pineda, Rachel Lau, Diane H Cho, Sandy L Baccam, Michelle M Axford, John D Cleary, James M Moore, Bryce L Sopher, Stephen J Tapscott, Galina N Filippova, Christopher E Pearson, Albert R La Spada   +13 more
doaj   +1 more source