Results 51 to 60 of about 1,126,913 (153)
Drug Targeting of Genomic Instability in Multiple Myeloma
Frontiers in Genetics, 2020 Genomic instability can be observed at both chromosomal and chromatin levels. Instability at the macro level includes centrosome abnormalities (CA) resulting in numerical as well as structural chromosomal changes, whereas instability at the micro level ...
Meral Beksac +2 more
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Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks
Nature Communications, 2019 Occurrence of DNA double-strand break (DSB) repair is important for genome integrity. Here, the authors reveal that Pellino1 is a DSB-responsive ubiquitin ligase required for promoting the accumulation of ATM and MRN complex at DSB sites via NBS1 ...
Geun-Hyoung Ha +12 more
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, 2017 [[abstract]]Nasopharyngeal carcinoma (NPC) is a serious health problem in China and Southeast Asia. Relapse is the major cause of mortality, but mechanisms of relapse are mysterious. Epstein-Barr virus (EBV) reactivation and host genomic instability (GI)
Huang, SY;Wu, CC;Cheng, YJ;Chou, SP;Jiang, YJ;Chu, KC;Tsai, CH;Lin, SF;Chen, JY
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Bcr/Abl Interferes with the Fanconi Anemia/BRCA Pathway: Implications in the Chromosomal Instability of Chronic Myeloid Leukemia Cells [PDF]
, 2010 Chronic myeloid leukemia (CML) is a malignant clonal disorder of the hematopoietic system caused by the expression of the BCR/ABL fusion oncogene. Although it is well known that CML cells are genetically unstable, the mechanisms accounting for this ...
Valeri, Antonio +71 more
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, 2022 Aging is a complex process of damage accumulation causing a functional decline. Several hallmarks of aging have been identified, of which, genomic instability plays a critical role in aging and age-related diseases and closely interacts with other ...
Anugula, Sharath +2 more
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Modeling Genomic Instability and Selection Pressure in a Mouse Model of Melanoma
Cell Reports, 2017 Tumor evolution is an iterative process of selection for pro-oncogenic aberrations. This process can be accelerated by genomic instability, but how it interacts with different selection bottlenecks to shape the evolving genomic landscape remains ...
Lawrence N. Kwong +9 more
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SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis
Cell Death and DiseaseSETD8 is a methyltransferase that is overexpressed in several cancers, which monomethylates H4K20 as well as other non-histone targets such as PCNA or p53.
Matilde Murga +18 more
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Frontiers in Public Health, 2014 There is limited understanding of how radiation or chemicals induce genomic instability, and how the instability is epigenetically transmitted to the progeny of exposed cells or organisms.
Katriina eHuumonen +6 more
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Parameter Identifiability and Redundancy in a General Class of Stochastic Carcinogenesis Models [PDF]
, 2009 Background Heidenreich et al. (Risk Anal 1997 17 391–399) considered parameter identifiability in the context of the two-mutation cancer model and demonstrated that combinations of all but two of the model parameters are identifiable.
Wolfgang F Heidenreich +11 more
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The role of Ephexin1 in translation and mTOR-targeted cancer therapy
Experimental and Molecular MedicineEphexin1, also known as neuronal guanine nucleotide exchange factor (NGEF), plays a key role in axon guidance and synaptic homeostasis. However, our recent studies have revealed a critical role for Ephexin1 in the pathogenesis of colon and lung cancers ...
Jeeho Kim +5 more
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