Results 51 to 60 of about 184,862 (303)
mBioDNA polymerase ε (Polε) is an essential replicative polymerase consisting of Pol2, Dpb2, Dpb3, and Dpb4 subunits and has not been explored in the pathogenic yeast Candida albicans. C. albicans is accountable for >40% of deaths due to systemic candidiasis
Bhabasha Gyanadeep Utkalaja +4 more
doaj +1 more source
A Proteomic Characterization of Factors Enriched at Nascent DNA Molecules
Cell Reports, 2013 DNA replication is facilitated by multiple factors that concentrate in the vicinity of replication forks. Here, we developed an approach that combines the isolation of proteins on nascent DNA chains with mass spectrometry (iPOND-MS), allowing a ...
Andres J. Lopez-Contreras +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
The Presence of Genomic Instability in Cerebrospinal Fluid in Patients with Meningeal Metastasis
, 2021 Peng Wang,1,2,* Henghui Zhang,3 Peng Chen,3 Zengfeng Sun,1,2 Zhen Zhang,1,2 Qiang Yin,1,2 Huaibo Sun,3 Jinpu Yu2,4,* 1Department of Neuro-Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer ...
Wang P +7 more
core
, 2022 Aging is a complex process of damage accumulation causing a functional decline. Several hallmarks of aging have been identified, of which, genomic instability plays a critical role in aging and age-related diseases and closely interacts with other ...
Anugula, Sharath +2 more
core +1 more source
Plk1 gene regulatory network involved in genomic instability
, 2022 Recently, the dynamics behind the events of genomic instability have gained relevance due to their association with specific genes and cellular mechanisms, which are presented as new and powerful therapeutic alternatives for the disease. Previous studies
Suescum H, J (via Mendeley Data)
core +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Early lesions of follicular lymphoma: a genetic perspective
Haematologica, 2014 The pathogenesis of follicular lymphoma is a multi-hit process progressing over many years through the accumulation of numerous genetic alterations. Besides the hallmark t(14;18), it is still unclear which other oncogenic hits contribute to the early ...
Emilie Mamessier +14 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Cells, 2023 Genomic instability is a prominent hallmark of cancer, however the mechanisms that drive and sustain this process remain elusive. Research demonstrates that numerous cancers with increased levels of genomic instability ectopically express meiosis ...
Jennifer Gantchev +13 more
doaj +1 more source