Results 21 to 30 of about 184,862 (303)
Cells, 2022 DNA double-strand breaks (DSBs) are one of the most lethal types of DNA damage due to the fact that unrepaired or mis-repaired DSBs lead to genomic instability or chromosomal aberrations, thereby causing cell death or tumorigenesis.
Muddenahalli Srinivasa Sudhanva +6 more
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Genomic Instability in Cancer [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 One of the fundamental challenges facing the cell is to accurately copy its genetic material to daughter cells. When this process goes awry, genomic instability ensues in which genetic alterations ranging from nucleotide changes to chromosomal translocations and aneuploidy occur.
Tarek, Abbas +2 more
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CtIP Regulates Mitotic Spindle Assembly by Modulating the TPX2-Aurora A Signaling Axis
Cells, 2022 CtBP-interacting protein (CtIP) plays a critical role in controlling the homologous recombination-mediated DNA double-stranded break (DSB) repair pathway through DNA end resection, and recent studies suggest that it also plays a role in mitosis. However,
Wonkyung Oh +4 more
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Scientific Reports, 2022 The ongoing COVID-19 pandemic is one of the biggest health challenges of recent decades. Among the causes of mortality triggered by SARS-CoV-2 infection, the development of an inflammatory “cytokine storm” (CS) plays a determinant role.
Laura Sanchez-Burgos +3 more
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Genomic Instability and Cancer [PDF]
Journal of Carcinogenesis & Mutagenesis, 2014 Genomic instability is a characteristic of most cancer cells. It is an increased tendency of genome alteration during cell division. Cancer frequently results from damage to multiple genes controlling cell division and tumor suppressors. It is known that genomic integrity is closely monitored by several surveillance mechanisms, DNA damage checkpoint ...
Yixin, Yao, Wei, Dai
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Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes [PDF]
, 2010 Background The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division.
Chaplin Tracy +14 more
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DNMTs are required for delayed genome instability caused by radiation [PDF]
, 2012 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited ...
Anderson, Rhona +26 more
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Interactions between EGFR and EphA2 promote tumorigenesis through the action of Ephexin1
Cell Death and Disease, 2022 The cell signaling factors EGFR, EphA2, and Ephexin1 are associated with lung and colorectal cancer and play an important role in tumorigenesis. Although the respective functional roles of EGFR and EphA2 are well known, interactions between these ...
Jeeho Kim, In-Youb Chang, Ho Jin You
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Protocol for analysis of G2/M DNA synthesis in human cells
STAR Protocols, 2021 Summary: G2/M DNA synthesis (G-MiDS) can be observed in one in five G2/M cells in unperturbed conditions by immunofluorescence microscopy. However, little is known of the genomic sites undergoing G-MiDS.
Jianming Wang, Marco Saponaro
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Biomonitoring and predictive modelling of genomic instability in childhood obesity [PDF]
, 2023 Epidemiological evidence indicates obesity in childhood and adolescence to be an independent risk factor for cancer and premature mortality in adulthood. Pathological implications from excess adiposity may begin early in life.
Bilkevic, I. +10 more
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