Biomonitoring and predictive modelling of genomic instability in childhood obesity [PDF]
, 2023 Epidemiological evidence indicates obesity in childhood and adolescence to be an independent risk factor for cancer and premature mortality in adulthood. Pathological implications from excess adiposity may begin early in life.
Bilkevic, I. +10 more
core +4 more sources
Systematic analysis of genomic alterations in prostate cancer [PDF]
, 2011 PhDProstate cancer is the most common male cancer in Western countries. The genetic mechanism underlying its initiation and progression is still unclear.
Mao, Xueying
core +4 more sources
Genomic instability and the link to infertility: A focus on microsatellites and genomic instability syndromes [PDF]
, 2022 Infertility is associated to multiple types of different genomic instabilities and is a genetic feature of genomic instability syndromes. While the mismatch repair machinery contributes to the maintenance of genome integrity, surprisingly its potential ...
Sen Gupta, Sioban +3 more
core +2 more sources
Obesity, oxidative DNA damage and vitamin D as predictors of genomic instability in children and adolescents [PDF]
, 2021 Background/objectives Epidemiological evidence indicates obesity in childhood and adolescence to be an independent risk factor for cancer and premature mortality in adulthood.
Bilkevic, I. +10 more
core +1 more source
The Adenylate-Uridylate-Rich element RNA binding protein ZFP36L1 suppresses replication stress-induced genomic instability [PDF]
, 2023 The RNA binding protein (RBP) ZFP36L1, which binds to adenylate/uridylate (AU)-rich elements (AREs) (AU-RBP) in the 3’ untranslated region of many messenger RNAs, has been extensively characterised for its role in post-transcriptional control of gene ...
Sidali, A.
core +1 more source
Scientific Reports, 2022 The ongoing COVID-19 pandemic is one of the biggest health challenges of recent decades. Among the causes of mortality triggered by SARS-CoV-2 infection, the development of an inflammatory “cytokine storm” (CS) plays a determinant role.
Laura Sanchez-Burgos +3 more
doaj +1 more source
The Role of the RNA-binding Protein ZFP36L1 in Suppression of Replication Stress-induced Genomic Instability [PDF]
, 2021 Replication stress, a hallmark of pre-cancerous and cancerous lesions, is characterised by the slowing or stalling in replication fork progression and the consequent failure to preserve genomic stability.
Shaikh Solaiman, N.
core +1 more source
Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes [PDF]
, 2010 Background The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division.
Chaplin Tracy +14 more
core +1 more source
DNMTs are required for delayed genome instability caused by radiation [PDF]
, 2012 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited ...
Anderson, Rhona +26 more
core +1 more source
Interactions between EGFR and EphA2 promote tumorigenesis through the action of Ephexin1
Cell Death and Disease, 2022 The cell signaling factors EGFR, EphA2, and Ephexin1 are associated with lung and colorectal cancer and play an important role in tumorigenesis. Although the respective functional roles of EGFR and EphA2 are well known, interactions between these ...
Jeeho Kim, In-Youb Chang, Ho Jin You
doaj +1 more source