Results 11 to 20 of about 184,862 (303)

Genomic instability and the link to infertility: A focus on microsatellites and genomic instability syndromes [PDF]

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2022
Infertility is associated to multiple types of different genomic instabilities and is a genetic feature of genomic instability syndromes. While the mismatch repair machinery contributes to the maintenance of genome integrity, surprisingly its potential role in infertility is overlooked. Defects in mismatch repair mechanisms contribute to microsatellite
Wieland, Jack, Buchan, Sarah, Sen Gupta, Sioban, Mantzouratou, Anna   +3 more
openaire   +5 more sources

MicroRNAs, Genomic Instability and Cancer [PDF]

International Journal of Molecular Sciences, 2014
MicroRNAs (miRNAs) are small non-coding RNA transcripts approximately 20 nucleotides in length that regulate expression of protein-coding genes via complementary binding mechanisms. The last decade has seen an exponential increase of publications on miRNAs, ranging from every aspect of basic cancer biology to diagnostic and therapeutic explorations ...
Vincent, Kimberly, Pichler, Martin, Lee, Gyeong-Won, Ling, Hui   +3 more
openaire   +5 more sources

Genomic instability and colon carcinogenesis: from the perspective of genes

Frontiers in Oncology, 2013
Colon cancer is the second most lethal cancer; approximately 600,000 people die of it annually in the world. Colon carcinogenesis generally follows a slow and stepwise process of accumulation of mutations under the influence of environmental and ...
Chinthalapally V Rao, Hiroshi Y Yamada
doaj   +2 more sources

Obesity, oxidative DNA damage and vitamin D as predictors of genomic instability in children and adolescents [PDF]

, 2021
Background/objectives Epidemiological evidence indicates obesity in childhood and adolescence to be an independent risk factor for cancer and premature mortality in adulthood.
Bilkevic, I., Bain, M., Glassar, B., Volpi, E., Britto, J.C., Chapman, S., Desai, A., Ford-Adams, M.E., Woloshynowych, M., Usman, M., Tewfik, I.   +10 more
core   +1 more source

The Adenylate-Uridylate-Rich element RNA binding protein ZFP36L1 suppresses replication stress-induced genomic instability [PDF]

, 2023
The RNA binding protein (RBP) ZFP36L1, which binds to adenylate/uridylate (AU)-rich elements (AREs) (AU-RBP) in the 3’ untranslated region of many messenger RNAs, has been extensively characterised for its role in post-transcriptional control of gene ...
Sidali, A.
core   +1 more source

Spot Assay and Colony Forming Unit (CFU) Analyses–based sensitivity test for Candida albicans and Saccharomyces cerevisiae

Bio-Protocol, 2023
Cellular sensitivity is an approach to inhibit the growth of certain cells in response to any non-permissible conditions, as the presence of a cytotoxic agent or due to changes in growth parameters such as temperature, salt, or media components ...
Satya Sahu, Bhabasha Utkalaja, Shraddheya Patel, Narottam Acahrya   +3 more
doaj   +1 more source

The Role of the RNA-binding Protein ZFP36L1 in Suppression of Replication Stress-induced Genomic Instability [PDF]

, 2021
Replication stress, a hallmark of pre-cancerous and cancerous lesions, is characterised by the slowing or stalling in replication fork progression and the consequent failure to preserve genomic stability.
Shaikh Solaiman, N.
core   +1 more source

Cell Cycle Analysis of Candida albicans by Flow Cytometry

Bio-Protocol, 2023
The cell cycle is a vital process of cell division that is required to sustain life. Since faithful cell division is critical for the proper growth and development of an organism, the study of the cell cycle becomes a fundamental research objective ...
Shraddheya Patel, Satya Sahu, Narottam Acahrya   +2 more
doaj   +1 more source

Vaccines against candidiasis: Status, challenges and emerging opportunity

Frontiers in Cellular and Infection Microbiology, 2022
Candidiasis is a mycosis caused by opportunistic Candida species. The occurrence of fungal infections has considerably increased in the last few years primarily due to an increase in the number of immune-suppressed individuals.
Satya Ranjan Sahu, Satya Ranjan Sahu, Swagata Bose, Swagata Bose, Manish Singh, Premlata Kumari, Premlata Kumari, Abinash Dutta, Bhabasha Gyanadeep Utkalaja, Bhabasha Gyanadeep Utkalaja, Shraddheya Kumar Patel, Shraddheya Kumar Patel, Narottam Acharya   +12 more
doaj   +1 more source

MicroRNAs and genomic instability [PDF]

Seminars in Cancer Biology, 2007
A new species of non-coding RNA, microRNAs (miRNAs) has been identified that may regulate the expression of as many as one third to one half of all protein encoding genes. MicroRNAs are found throughout mammalian genomes, but an association between the location of these miRNAs and regions of genomic instability (or fragile sites) in humans has been ...
Konrad, Huppi, Natalia, Volfovsky, Mark, Mackiewicz, Timothy, Runfola, Tamara L, Jones, Scott E, Martin, Robert, Stephens, Natasha J, Caplen   +7 more
openaire   +2 more sources