Results 41 to 50 of about 12,279 (184)

Biogenesis of Iron–Sulfur Clusters and Their Role in DNA Metabolism

Frontiers in Cell and Developmental Biology, 2021
Iron–sulfur (Fe/S) clusters (ISCs) are redox-active protein cofactors that their synthesis, transfer, and insertion into target proteins require many components. Mitochondrial ISC assembly is the foundation of all cellular ISCs in eukaryotic cells.
Ruifeng Shi, Ruifeng Shi, Wenya Hou, Zhao-Qi Wang, Zhao-Qi Wang, Xingzhi Xu, Xingzhi Xu   +6 more
doaj   +1 more source

Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney [PDF]

, 2014
Inflammation is accompanied by the release of highly reactive oxygen and nitrogen species (RONS) that damage DNA, among other cellular molecules. Base excision repair (BER) is initiated by DNA glycosylases and is crucial in repairing RONS-induced DNA ...
Abolhassani, Nona, Allocca, Mariacarmela, Ayata, Cenk, Calvo, Jennifer A., Daneshmand, Ali, Ebrahimkhani, Mohammad Reza, Jhun, Iny, Mazumder, Aprotim, Muthupalani, Sureshkumar, Samson, Leona D   +9 more
core   +1 more source

The catalytic core of DEMETER guides active DNA demethylation in Arabidopsis. [PDF]

, 2019
The Arabidopsis DEMETER (DME) DNA glycosylase demethylates the maternal genome in the central cell prior to fertilization and is essential for seed viability.
Aravind, L., Fischer, Robert L., Frost, Jennifer M., Hsieh, Tzung-Fu, Huh, Jin Hoe, Hung, Yu-Hung, Iyer, Lakshminarayan M., Jang, Hosung, Liu, Fang, Rim, Hyun Jung, Shin, Hosub, Xiao, Wenyan, Zhang, Changqing, Zhang, Dapeng, Zhang, Xiang-Qian, 허진회   +15 more
core   +2 more sources

Expression patterns of Neil3 during embryonic brain development and neoplasia

BMC Neuroscience, 2009
Background The base excision repair pathway is responsible for repairing small DNA base lesions caused by endogenous and exogenous damaging agents. Repair is initiated by DNA glycosylases that recognize and remove the lesions.
Bjørås Magnar, Krauss Stefan, Castellanos Cesilie G, Diep Dzung B, Neurauter Christine G, Hildrestrand Gunn A, Luna Luisa   +6 more
doaj   +1 more source

Dataset for dynamics and conformational changes in human NEIL2 protein analyzed by integrative structural biology approach

Data in Brief, 2022
This work presents new data on human endonuclease VIII-like 2 protein (hNEIL2), a part of DNA glycosylases of the helix–two-turn–helix structural superfamily. While X-ray structure of oNEIL2 (opossum Monodelphis) was resolved partially [1], the structure
Polina V. Zhdanova, Alexander A. Ishchenko, Alexander A. Chernonosov, Dmitry O. Zharkov, Vladimir V. Koval   +4 more
doaj   +1 more source

DNA demethylation pathways: Additional players and regulators. [PDF]

, 2017
DNA demethylation can occur passively by "dilution" of methylation marks by DNA replication, or actively and independently of DNA replication. Direct conversion of 5-methylcytosine (5mC) to cytosine (C), as originally proposed, does not occur.
Abdouni, An, Arakawa, Barreto, Bellon, Bhutani, Bhutani, Blaschke, Boorstein, Bourc'his, Bransteitter, Brown, Buganim, Chakraborty, Chen, Chen, Chen, Chowdhury, Chung, Cortazar, Cortellino, Costa, Dai, Dai, Dang, Dawlaty, Dawlaty, Dawlaty, Delhommeau, Doege, Dominguez, Engel, Fortini, Foshay, Fousteri, Franchini, Fritz, Fritz, Gao, Ge, Gehring, Gjini, Grin, Gu, Guo, Guo, Habib, Hajkova, Hashimoto, Hashimoto, Hashimoto, Hashimoto, Hata, Hata, He, Henson, Hildrestrand, Hogenbirk, Hollander, Hon, Hu, Hu, Iiams, Inoue, Iqbal, Ito, Iyer, Jin, Jin, Jiricny, Jones, Kagiwada, Kaneda, Kellinger, Ko, Kosmider, Kou, Kriaucionis, Krokan, Kumar, Langemeijer, Larijani, Laukka, Lenz, Li, Li, Li, Li, Liu, Liutkeviciute, Lorsbach, Lu, Ma, Maiti, Maiti, Marusawa, Mayer, Moran-Crusio, Muller, Muramatsu, Muramatsu, Nabel, Nakanishi, Nemec, Niehrs, Nilsen, Ohno, Okano, Ooi, Pais, Pastor, Perez, Petersen-Mahrt, Pfaffeneder, Pollard, Popp, Rai, Raiber, Ramiro, Rangam, Revy, Rommel, Rusmintratip, Sabag, Sajadian, Santos, Schiesser, Schiesser, Schmitz, Schomacher, Sciacovelli, Sejersted, Shen, Shen, Shibutani, Shimamoto, Shimoda, Silverman, Spruijt, Stier, Szulik, Tahiliani, Tamura, Tan, Vartanian, Verdine, Wagner, Wang, Weber, Wijesinghe, Wojciechowski, Wu, Xiao, Xu, Xu, Xu, Xue, Yamazaki, Yin, Young, Zanotti, Zhao, Zhu   +162 more
core   +1 more source

Targeted DNA demethylation in human cells by fusion of a plant 5-methylcytosine DNA glycosylase to a sequence-specific DNA binding domain

Epigenetics, 2017
DNA methylation is a crucial epigenetic mark associated to gene silencing, and its targeted removal is a major goal of epigenetic editing. In animal cells, DNA demethylation involves iterative 5mC oxidation by TET enzymes followed by replication ...
Jara Teresa Parrilla-Doblas, Rafael R. Ariza, Teresa Roldán-Arjona   +2 more
doaj   +1 more source

Retinoblastoma makes its mark on imprinting in plants [PDF]

, 2008
Genomic imprinting results in the preferential expression of alleles from either the maternal or paternal chromosomes. This epigenetic process occurs in embryonic and extra-embryonic (placental) tissues of mammals, but only in the extra-embryonic ...
Liliana M Costa, José F Gutierrez-Marcos, Wolf, Youngson, Spillane, Kermicle, Feil, Delaval, Bourc&apos, Schoenherr, Mager, Lewis, Gutierrez-Marcos, Kinoshita, Jullien, Choi, Morales-Ruiz, Reik, McCabe, Jung, Ebel, Hennig, Guitton, Ingouff, Jullien, Kimura, Rossi, Wu, Mathieu, Wu   +29 more
core   +2 more sources

DNA demethylation by ROS1a in rice vegetative cells promotes methylation in sperm. [PDF]

, 2019
Epigenetic reprogramming is required for proper regulation of gene expression in eukaryotic organisms. In Arabidopsis, active DNA demethylation is crucial for seed viability, pollen function, and successful reproduction. The DEMETER (DME) DNA glycosylase
Fischer, Robert L, Kim, M Yvonne, Kinoshita, Tetsu, Okamoto, Takashi, Ono, Akemi, Scholten, Stefan, Zilberman, Daniel   +6 more
core   +2 more sources

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source