Results 41 to 50 of about 7,033 (174)
Poxvirus uracil-DNA glycosylase-An unusual member of the family I uracil-DNA glycosylases. [PDF]
Protein Sci, 2016 AbstractUracil‐DNA glycosylases are ubiquitous enzymes, which play a key role repairing damages in DNA and in maintaining genomic integrity by catalyzing the first step in the base excision repair pathway. Within the superfamily of uracil‐DNA glycosylases family I enzymes or UNGs are specific for recognizing and removing uracil from DNA.
Schormann N +8 more
europepmc +4 more sources
Plant and fungal Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases [PDF]
DNA Repair, 2009 Formamidopyrimidine DNA glycosylase (Fpg) and endonuclease VIII (Nei) share an overall common three-dimensional structure and primary amino acid sequence in conserved structural motifs but have different substrate specificities, with bacterial Fpg proteins recognizing formamidopyrimidines, 8-oxoguanine (8-oxoG) and its oxidation products ...
Scott D, Kathe +8 more
openaire +2 more sources
Nature Communications, 2020 DNA glycosylases are lesion-specific enzymes that recognize specific nucleobase damages and catalyze their excision through cleavage of the glycosidic bond.
Uddhav K. Shigdel +6 more
doaj +1 more source
Characterization of demethylating DNA glycosylase ROS1 from Nicotiana tabacum L.
Вавиловский журнал генетики и селекции, 2022 One of the main mechanisms of epigenetic regulation in higher eukaryotes is based on the methylation of cytosine at the C5 position with the formation of 5-methylcytosine (mC), which is further recognized by regulatory proteins.
D. V. Petrova +3 more
doaj +1 more source
Biogenesis of Iron–Sulfur Clusters and Their Role in DNA Metabolism
Frontiers in Cell and Developmental Biology, 2021 Iron–sulfur (Fe/S) clusters (ISCs) are redox-active protein cofactors that their synthesis, transfer, and insertion into target proteins require many components. Mitochondrial ISC assembly is the foundation of all cellular ISCs in eukaryotic cells.
Ruifeng Shi +6 more
doaj +1 more source
Expression patterns of
BMC Neuroscience, 2009 Background The base excision repair pathway is responsible for repairing small DNA base lesions caused by endogenous and exogenous damaging agents. Repair is initiated by DNA glycosylases that recognize and remove the lesions.
Bjørås Magnar +6 more
doaj +1 more source
Data in Brief, 2022 This work presents new data on human endonuclease VIII-like 2 protein (hNEIL2), a part of DNA glycosylases of the helix–two-turn–helix structural superfamily. While X-ray structure of oNEIL2 (opossum Monodelphis) was resolved partially [1], the structure
Polina V. Zhdanova +4 more
doaj +1 more source
Active DNA Demethylation Mediated by DNA Glycosylases [PDF]
Annual Review of Genetics, 2009 Active DNA demethylation is involved in many vital developmental and physiological processes of plants and animals. Recent genetic and biochemical studies in Arabidopsis have demonstrated that a subfamily of DNA glycosylases function to promote DNA demethylation through a base excision-repair pathway.
openaire +2 more sources
Epigenetics, 2017 DNA methylation is a crucial epigenetic mark associated to gene silencing, and its targeted removal is a major goal of epigenetic editing. In animal cells, DNA demethylation involves iterative 5mC oxidation by TET enzymes followed by replication ...
Jara Teresa Parrilla-Doblas +2 more
doaj +1 more source
Repair of oxidative DNA base damage in the host genome influences the HIV integration site sequence preference. [PDF]
PLoS ONE, 2014 Host base excision repair (BER) proteins that repair oxidative damage enhance HIV infection. These proteins include the oxidative DNA damage glycosylases 8-oxo-guanine DNA glycosylase (OGG1) and mutY homolog (MYH) as well as DNA polymerase beta (Polβ ...
Geoffrey R Bennett +7 more
doaj +1 more source