Results 41 to 50 of about 7,004 (177)
Nature Communications, 2020 DNA glycosylases are lesion-specific enzymes that recognize specific nucleobase damages and catalyze their excision through cleavage of the glycosidic bond.
Uddhav K. Shigdel +6 more
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DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers. [PDF]
PLoS Genetics, 2014 Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of ...
Ana Osorio +199 more
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Biogenesis of Iron–Sulfur Clusters and Their Role in DNA Metabolism
Frontiers in Cell and Developmental Biology, 2021 Iron–sulfur (Fe/S) clusters (ISCs) are redox-active protein cofactors that their synthesis, transfer, and insertion into target proteins require many components. Mitochondrial ISC assembly is the foundation of all cellular ISCs in eukaryotic cells.
Ruifeng Shi +6 more
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Data in Brief, 2022 This work presents new data on human endonuclease VIII-like 2 protein (hNEIL2), a part of DNA glycosylases of the helix–two-turn–helix structural superfamily. While X-ray structure of oNEIL2 (opossum Monodelphis) was resolved partially [1], the structure
Polina V. Zhdanova +4 more
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Structural Basis for Nucleobase Activation by the Adenine DNA Glycosylase MutY. [PDF]
ChembiochemDNA glycosylase MutY engages its adenine nucleobase substrate in a syn orientation with a catalytic Glu. X‐ray crystal structures of MutY with Glu replaced suggest that a disengaged “on hold” state with anti nucleobase orientation may explain how MutY avoids catastrophic activity at inappropriate adenines.
Russelburg LP +4 more
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Expression patterns of
BMC Neuroscience, 2009 Background The base excision repair pathway is responsible for repairing small DNA base lesions caused by endogenous and exogenous damaging agents. Repair is initiated by DNA glycosylases that recognize and remove the lesions.
Bjørås Magnar +6 more
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Repair of oxidative DNA base damage in the host genome influences the HIV integration site sequence preference. [PDF]
PLoS ONE, 2014 Host base excision repair (BER) proteins that repair oxidative damage enhance HIV infection. These proteins include the oxidative DNA damage glycosylases 8-oxo-guanine DNA glycosylase (OGG1) and mutY homolog (MYH) as well as DNA polymerase beta (Polβ ...
Geoffrey R Bennett +7 more
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Active DNA Demethylation Mediated by DNA Glycosylases [PDF]
Annual Review of Genetics, 2009 Active DNA demethylation is involved in many vital developmental and physiological processes of plants and animals. Recent genetic and biochemical studies in Arabidopsis have demonstrated that a subfamily of DNA glycosylases function to promote DNA demethylation through a base excision-repair pathway.
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Structure of a DNA Glycosylase Searching for Lesions [PDF]
Science, 2006 DNA glycosylases must interrogate millions of base pairs of undamaged DNA in order to locate and then excise one damaged nucleobase. The nature of this search process remains poorly understood. Here we report the use of disulfide cross-linking (DXL) technology to obtain structures of a bacterial DNA glycosylase, MutM, interrogating undamaged DNA. These
Anirban, Banerjee +2 more
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Epigenetics, 2017 DNA methylation is a crucial epigenetic mark associated to gene silencing, and its targeted removal is a major goal of epigenetic editing. In animal cells, DNA demethylation involves iterative 5mC oxidation by TET enzymes followed by replication ...
Jara Teresa Parrilla-Doblas +2 more
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