Results 21 to 30 of about 59,918 (258)
DNA Repair Repertoire of the Enigmatic Hydra
Frontiers in Genetics, 2021 Since its discovery by Abraham Trembley in 1744, hydra has been a popular research organism. Features like spectacular regeneration capacity, peculiar tissue dynamics, continuous pattern formation, unique evolutionary position, and an apparent lack of ...
Apurva Barve +4 more
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Base Excision Repair in the Mitochondria [PDF]
Journal of Cellular Biochemistry, 2015 ABSTRACTThe 16.5 kb human mitochondrial genome encodes for 13 polypeptides, 22 tRNAs and 2 rRNAs involved in oxidative phosphorylation. Mitochondrial DNA (mtDNA), unlike its nuclear counterpart, is not packaged into nucleosomes and is more prone to the adverse effects of reactive oxygen species (ROS) generated during oxidative phosphorylation. The past
Aishwarya, Prakash, Sylvie, Doublié
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OGG1 in Lung—More than Base Excision Repair
Antioxidants, 2022 As the organ executing gas exchange and directly facing the external environment, the lungs are challenged continuously by various stimuli, causing the disequilibration of redox homeostasis and leading to pulmonary diseases.
Xiaodi Ma +6 more
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Nature Communications, 2022 Nucleotide excision repair proteins are involved in the repair of UV-induced DNA damage. Here, the authors show that NER proteins, DDB2, XPC, and XPA play a vital role in the 8-oxoguanine repair by coordinating with base excision repair protein OGG1.
Namrata Kumar +11 more
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Base Flipping in Nucleotide Excision Repair [PDF]
Journal of Biological Chemistry, 2006 UvrB, the ultimate damage-binding protein in bacterial nucleotide excision repair is capable of binding a vast array of structurally unrelated lesions. A beta-hairpin structure in the protein plays an important role in damage-specific binding. In this paper we have monitored DNA conformational alterations in the UvrB-DNA complex, using the fluorescent ...
Malta, E., Moolenaar, G.F., Goosen, N.
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Cooperation and interplay between base and nucleotide excision repair pathways: From DNA lesions to proteins [PDF]
Genetics and Molecular Biology, 2020 Base and nucleotide excision repair (BER and NER) pathways are normally associated with removal of specific types of DNA damage: small base modifications (such as those induced by DNA oxidation) and bulky DNA lesions (such as those induced by ultraviolet
Namrata Kumar +4 more
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The Role of DNA Damage and Repair in Idiopathic Pulmonary Fibrosis
Antioxidants, 2022 The mortality rate of idiopathic pulmonary fibrosis (IPF) increases yearly due to ineffective treatment. Given that the lung is exposed to the external environment, it is likely that oxidative stress, especially the stimulation of DNA, would be of ...
Jiahui Zhu +10 more
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Extended Frontobasal Approach for Skull Base Lesions
Indian Journal of Neurosurgery, 2021 Background Lesions involving the skull base can be approached by a variety of surgical corridors and extended frontobasal approach is one of them. It provides quite a wide exposure to lesions in the midline of anterior skull base, paranasal sinuses, and ...
Mohd Faheem +2 more
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Reactome - a curated knowledgebase of biological pathways, 2004 Publisher Summary The covalent structure of the nucleobases in DNA and RNA directly provides the information for all genetic transactions. Living systems expend considerable energy in an ongoing struggle against spontaneous genetic change. The most wide-ranging threat to genetic integrity is posed by the attack of environmental agents on DNA ...
J Christopher, Fromme +1 more
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Nature Communications, 2018 PARP1 has a well characterised role in DNA break repair and base excision repair, whereas the role of PARP2 is less well understood. Here, the authors show a requirement for PARP2 in stabilising replication forks that encounter base excision repair ...
George E. Ronson +7 more
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