Results 21 to 30 of about 64,997 (303)

DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers. [PDF]

open access: yes, 2014
Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of ...
Backes, F.J. (Floor)   +999 more
core   +1 more source

Research Advances on Base Excision Repair Factor SmuG1 and Tumor

open access: yesZhongliu Fangzhi Yanjiu, 2019
Tumor is one of the diseases that seriously threaten human health. With the deepening of research, it is found that the role of DNA damage in the occurrence and development of tumors is more and more important.
ZHENG Lijiao   +3 more
doaj   +1 more source

A function of thymine DNA glycosylase-initiated DNA repair in maintaining epigenome stability [PDF]

open access: yes, 2013
The Thymine DNA Glycosylase (TDG) was initially discovered by its ability to excise the deamination products of cytosine and 5-methylcytosine (5-mC), and therefore thought to initiate base excision repair (BER) of the resulting G•U and G•T mismatches.
Jacobs, Angelika L.
core   +1 more source

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

open access: yesNature Communications, 2018
PARP1 has a well characterised role in DNA break repair and base excision repair, whereas the role of PARP2 is less well understood. Here, the authors show a requirement for PARP2 in stabilising replication forks that encounter base excision repair ...
George E. Ronson   +7 more
doaj   +1 more source

High-throughput analysis of DNA repair in microplates towards identification of inhibitors

open access: yesGenes and Environment, 2020
Environmental factors can inhibit DNA repair and cause indirect mutagenic actions. Here the author introduces a recent paper on a novel high-throughput system to analyze the various enzymatic activities involved in base excision repair. Such systems will
Hiroyuki Kamiya
doaj   +1 more source

DNA Base Excision Repair Intermediates Influence Duplex–Quadruplex Equilibrium

open access: yesMolecules, 2023
Although genomic DNA is predominantly duplex under physiological conditions, particular sequence motifs can favor the formation of alternative secondary structures, including the G-quadruplex.
Mark L. Sowers   +5 more
doaj   +1 more source

Methionine Restriction Differentially Modulates Expression of Genes in the Base Excision Repair Pathway in Rat Brain and Liver. [PDF]

open access: yesBiomolecules
Methionine restriction (MetR) is a dietary intervention that extends mean and maximum life span in rodents, at least in part, by reducing oxidative stress and promoting DNA stability in different tissues. Regarding DNA stability, DNA repair pathways play
Gredilla R   +2 more
europepmc   +2 more sources

Viruses with U-DNA: New Avenues for Biotechnology

open access: yesViruses, 2021
Deoxyuridine in DNA has recently been in the focus of research due to its intriguing roles in several physiological and pathophysiological situations. Although not an orthodox DNA base, uracil may appear in DNA via either cytosine deamination or thymine ...
Kinga K. Nagy   +2 more
doaj   +1 more source

Oxidative stress and 8-oxoguanine repair are enhanced in colon adenoma and carcinoma patients. [PDF]

open access: yes, 2010
Oxidative stress is involved in the pathogenesis of colon cancer. We wanted to elucidate at which stage of the disease this phenomenon occurs. In the examined groups of patients with colorectal cancer (CRC, n = 89), benign adenoma (AD, n = 77) and ...
R. Rozalski   +31 more
core   +1 more source

Variation in base excision repair capacity [PDF]

open access: yesMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2011
The major DNA repair pathway for coping with spontaneous forms of DNA damage, such as natural hydrolytic products or oxidative lesions, is base excision repair (BER). In particular, BER processes mutagenic and cytotoxic DNA lesions such as non-bulky base modifications, abasic sites, and a range of chemically distinct single-strand breaks.
David M, Wilson   +3 more
openaire   +2 more sources

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