Results 21 to 30 of about 4,636,913 (295)

Resistance to Nucleotide Excision Repair of Bulky Guanine Adducts Opposite Abasic Sites in DNA Duplexes and Relationships between Structure and Function. [PDF]

PLoS ONE, 2015
The nucleotide excision repair of certain bulky DNA lesions is abrogated in some specific non-canonical DNA base sequence contexts, while the removal of the same lesions by the nucleotide excision repair mechanism is efficient in duplexes in which all ...
Zhi Liu, Shuang Ding, Konstantin Kropachev, Lei Jia, Shantu Amin, Suse Broyde, Nicholas E Geacintov   +6 more
doaj   +1 more source

Base Excision Repair [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
Base excision repair (BER) corrects DNA damage from oxidation, deamination and alkylation. Such base lesions cause little distortion to the DNA helix structure. BER is initiated by a DNA glycosylase that recognizes and removes the damaged base, leaving an abasic site that is further processed by short-patch repair or long-patch repair that largely uses
Hans E, Krokan, Magnar, Bjørås
openaire   +2 more sources

DNA Repair Repertoire of the Enigmatic Hydra

Frontiers in Genetics, 2021
Since its discovery by Abraham Trembley in 1744, hydra has been a popular research organism. Features like spectacular regeneration capacity, peculiar tissue dynamics, continuous pattern formation, unique evolutionary position, and an apparent lack of ...
Apurva Barve, Apurva Barve, Alisha A. Galande, Saroj S. Ghaskadbi, Surendra Ghaskadbi   +4 more
doaj   +1 more source

Base Excision Repair in the Mitochondria [PDF]

Journal of Cellular Biochemistry, 2015
ABSTRACTThe 16.5 kb human mitochondrial genome encodes for 13 polypeptides, 22 tRNAs and 2 rRNAs involved in oxidative phosphorylation. Mitochondrial DNA (mtDNA), unlike its nuclear counterpart, is not packaged into nucleosomes and is more prone to the adverse effects of reactive oxygen species (ROS) generated during oxidative phosphorylation. The past
Aishwarya, Prakash, Sylvie, Doublié
openaire   +2 more sources

OGG1 in Lung—More than Base Excision Repair

Antioxidants, 2022
As the organ executing gas exchange and directly facing the external environment, the lungs are challenged continuously by various stimuli, causing the disequilibration of redox homeostasis and leading to pulmonary diseases.
Xiaodi Ma, Hewei Ming, Lexin Liu, Jiahui Zhu, Lang Pan, Yu Chen, Yang Xiang   +6 more
doaj   +1 more source

Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins

Nature Communications, 2022
Nucleotide excision repair proteins are involved in the repair of UV-induced DNA damage. Here, the authors show that NER proteins, DDB2, XPC, and XPA play a vital role in the 8-oxoguanine repair by coordinating with base excision repair protein OGG1.
Namrata Kumar, Arjan F. Theil, Vera Roginskaya, Yasmin Ali, Michael Calderon, Simon C. Watkins, Ryan P. Barnes, Patricia L. Opresko, Alex Pines, Hannes Lans, Wim Vermeulen, Bennett Van Houten   +11 more
doaj   +1 more source

Base Flipping in Nucleotide Excision Repair [PDF]

Journal of Biological Chemistry, 2006
UvrB, the ultimate damage-binding protein in bacterial nucleotide excision repair is capable of binding a vast array of structurally unrelated lesions. A beta-hairpin structure in the protein plays an important role in damage-specific binding. In this paper we have monitored DNA conformational alterations in the UvrB-DNA complex, using the fluorescent ...
Malta, E., Moolenaar, G.F., Goosen, N.
openaire   +3 more sources

Cooperation and interplay between base and nucleotide excision repair pathways: From DNA lesions to proteins [PDF]

Genetics and Molecular Biology, 2020
Base and nucleotide excision repair (BER and NER) pathways are normally associated with removal of specific types of DNA damage: small base modifications (such as those induced by DNA oxidation) and bulky DNA lesions (such as those induced by ultraviolet
Namrata Kumar, Natália C. Moreno, Bruno C. Feltes, Carlos FM Menck, Bennett Van Houten   +4 more
doaj   +1 more source

The Role of DNA Damage and Repair in Idiopathic Pulmonary Fibrosis

Antioxidants, 2022
The mortality rate of idiopathic pulmonary fibrosis (IPF) increases yearly due to ineffective treatment. Given that the lung is exposed to the external environment, it is likely that oxidative stress, especially the stimulation of DNA, would be of ...
Jiahui Zhu, Lexin Liu, Xiaodi Ma, Xinyu Cao, Yu Chen, Xiangping Qu, Ming Ji, Huijun Liu, Chi Liu, Xiaoqun Qin, Yang Xiang   +10 more
doaj   +1 more source

Biochemical characterization and DNA repair pathway interactions of Mag1-mediated base excision repair in Schizosaccharomyces pombe [PDF]

, 2005
The Schizosaccharomyces pombe mag1 gene encodes a DNA repair enzyme with sequence similarity to the AlkA family of DNA glycosylases, which are essential for the removal of cytotoxic alkylation products, the premutagenic deamination product hypoxanthine ...
Alseth, I, Whitby, MC, Bjoras, M, Korvald, H, Tsaneva, I, Seeberg, E, Osman, F   +6 more
core   +1 more source