Results 31 to 40 of about 59,918 (258)
Research Advances on Base Excision Repair Factor SmuG1 and Tumor
Zhongliu Fangzhi Yanjiu, 2019 Tumor is one of the diseases that seriously threaten human health. With the deepening of research, it is found that the role of DNA damage in the occurrence and development of tumors is more and more important.
ZHENG Lijiao +3 more
doaj +1 more source
High-throughput analysis of DNA repair in microplates towards identification of inhibitors
Genes and Environment, 2020 Environmental factors can inhibit DNA repair and cause indirect mutagenic actions. Here the author introduces a recent paper on a novel high-throughput system to analyze the various enzymatic activities involved in base excision repair. Such systems will
Hiroyuki Kamiya
doaj +1 more source
DNA Base Excision Repair Intermediates Influence Duplex–Quadruplex Equilibrium
Molecules, 2023 Although genomic DNA is predominantly duplex under physiological conditions, particular sequence motifs can favor the formation of alternative secondary structures, including the G-quadruplex.
Mark L. Sowers +5 more
doaj +1 more source
Viruses with U-DNA: New Avenues for Biotechnology
Viruses, 2021 Deoxyuridine in DNA has recently been in the focus of research due to its intriguing roles in several physiological and pathophysiological situations. Although not an orthodox DNA base, uracil may appear in DNA via either cytosine deamination or thymine ...
Kinga K. Nagy +2 more
doaj +1 more source
Variation in base excision repair capacity [PDF]
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2011 The major DNA repair pathway for coping with spontaneous forms of DNA damage, such as natural hydrolytic products or oxidative lesions, is base excision repair (BER). In particular, BER processes mutagenic and cytotoxic DNA lesions such as non-bulky base modifications, abasic sites, and a range of chemically distinct single-strand breaks.
David M, Wilson +3 more
openaire +2 more sources
Mitochondrial base excision repair assays [PDF]
Methods, 2010 The main source of mitochondrial DNA (mtDNA) damage is reactive oxygen species (ROS) generated during normal cellular metabolism. The main mtDNA lesions generated by ROS are base modifications, such as the ubiquitous 8-oxoguanine (8-oxoG) lesion; however, base loss and strand breaks may also occur.
Maynard, Scott +3 more
openaire +3 more sources
Molecules, 2022 Endonuclease III (EndoIII) is a bifunctional DNA glycosylase with specificity for a broad range of oxidized DNA lesions. The genome of an extremely radiation- and desiccation-resistant bacterium, Deinococcus radiodurans, possesses three genes encoding ...
Filipe Rollo +5 more
doaj +1 more source
Overview of Base Excision Repair Biochemistry [PDF]
Current Molecular Pharmacology, 2012 Base excision repair (BER) is an evolutionarily conserved pathway, which could be considered the "workhorse" repair mechanism of the cell. In particular, BER corrects most forms of spontaneous hydrolytic decay products in DNA, as well as everyday oxidative and alkylative modifications to bases or the sugar phosphate backbone.
Yun-Jeong, Kim, David M, Wilson
openaire +2 more sources
Base Sequence Context Effects on Nucleotide Excision Repair
Journal of Nucleic Acids, 2010 Nucleotide excision repair (NER) plays a critical role in maintaining the integrity of the genome when damaged by bulky DNA lesions, since inefficient repair can cause mutations and human diseases notably cancer. The structural properties of DNA lesions
Yuqin Cai +3 more
doaj +1 more source
Sabiad, 2023 Objective: The purpose of this investigative research was to investigatethe potential impact of a single nucleotide polymorphism (Asp148Glu) within the APE1 gene on the development of bladder cancer (BCa) andspread, and to investigate the interaction of ...
Taghi Ahmadi Rendi +6 more
doaj +1 more source