Results 31 to 40 of about 4,636,913 (295)

Extended Frontobasal Approach for Skull Base Lesions

open access: yesIndian Journal of Neurosurgery, 2021
Background Lesions involving the skull base can be approached by a variety of surgical corridors and extended frontobasal approach is one of them. It provides quite a wide exposure to lesions in the midline of anterior skull base, paranasal sinuses, and ...
Mohd Faheem   +2 more
doaj   +1 more source

REPAIRtoire--a database of DNA repair pathways. [PDF]

open access: yes, 2010
REPAIRtoire is the first comprehensive database resource for systems biology of DNA damage and repair. The database collects and organizes the following types of information: (i) DNA damage linked to environmental mutagenic and cytotoxic agents, (ii ...
Rother, Kristian   +17 more
core   +1 more source

Base Excision Repair

open access: yesReactome - a curated knowledgebase of biological pathways, 2004
Publisher Summary The covalent structure of the nucleobases in DNA and RNA directly provides the information for all genetic transactions. Living systems expend considerable energy in an ongoing struggle against spontaneous genetic change. The most wide-ranging threat to genetic integrity is posed by the attack of environmental agents on DNA ...
J Christopher, Fromme   +1 more
openaire   +3 more sources

DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers. [PDF]

open access: yes, 2014
Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of ...
Backes, F.J. (Floor)   +999 more
core   +2 more sources

Oxidative stress and 8-oxoguanine repair are enhanced in colon adenoma and carcinoma patients. [PDF]

open access: yes, 2010
Oxidative stress is involved in the pathogenesis of colon cancer. We wanted to elucidate at which stage of the disease this phenomenon occurs. In the examined groups of patients with colorectal cancer (CRC, n = 89), benign adenoma (AD, n = 77) and ...
Swoboda, Maja   +15 more
core   +2 more sources

Functional Characterization of Excision Repair and RecA-Dependent Recombinational DNA Repair in Campylobacter jejuni [PDF]

open access: yes, 2009
The presence and functionality of DNA repair mechanisms in Campylobacter jejuni are largely unknown. In silico analysis of the complete translated genome of C.
Dep Infectieziekten Immunologie   +13 more
core   +1 more source

Hydrogen peroxide induced genomic instability in nucleotide excision repair-deficient lymphoblastoid cells [PDF]

open access: yes, 2010
Copyright @ 2010 Gopalakrishnan et al; licensee BioMed Central Ltd.Background The Nucleotide Excision Repair (NER) pathway specialises in UV-induced DNA damage repair. Inherited defects in the NER can predispose individuals to Xeroderma Pigmentosum (XP).
Gopalakrishnan, K   +14 more
core   +1 more source

Research Advances on Base Excision Repair Factor SmuG1 and Tumor

open access: yesZhongliu Fangzhi Yanjiu, 2019
Tumor is one of the diseases that seriously threaten human health. With the deepening of research, it is found that the role of DNA damage in the occurrence and development of tumors is more and more important.
ZHENG Lijiao   +3 more
doaj   +1 more source

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

open access: yesNature Communications, 2018
PARP1 has a well characterised role in DNA break repair and base excision repair, whereas the role of PARP2 is less well understood. Here, the authors show a requirement for PARP2 in stabilising replication forks that encounter base excision repair ...
George E. Ronson   +7 more
doaj   +1 more source

High-throughput analysis of DNA repair in microplates towards identification of inhibitors

open access: yesGenes and Environment, 2020
Environmental factors can inhibit DNA repair and cause indirect mutagenic actions. Here the author introduces a recent paper on a novel high-throughput system to analyze the various enzymatic activities involved in base excision repair. Such systems will
Hiroyuki Kamiya
doaj   +1 more source

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