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Nucleotide excision repair: a versatile and smart toolkit [PDF]
Acta Biochimica et Biophysica Sinica, 2022 Nucleotide excision repair (NER) is a major pathway to deal with bulky adducts induced by various environmental toxins in all cellular organisms. The two sub-pathways of NER, global genome repair (GGR) and transcription-coupled repair (TCR), differ in ...
Zhang Xiping, Yin Mengdie, Hu Jinchuan
doaj +3 more sources
Nature Communications, 2022 Nucleotide excision repair proteins are involved in the repair of UV-induced DNA damage. Here, the authors show that NER proteins, DDB2, XPC, and XPA play a vital role in the 8-oxoguanine repair by coordinating with base excision repair protein OGG1.
Namrata Kumar +11 more
doaj +2 more sources
Nature Communications, 2020 DNA damage sensors DDB2 and XPC are fundamental factors to initiate global genome nucleotide excision repair and protect DNA from mutagenesis. Here the authors reveal that ubiquitin and TFIIH-stimulated DDB2 dissociation promotes DNA damage handover to ...
Cristina Ribeiro-Silva +6 more
doaj +2 more sources
Epigenetic Regulation of Nucleotide Excision Repair
Frontiers in Cell and Developmental Biology, 2022 Genomic DNA is constantly attacked by a plethora of DNA damaging agents both from endogenous and exogenous sources. Nucleotide excision repair (NER) is the most versatile repair pathway that recognizes and removes a wide range of bulky and/or helix ...
Wentao Li +4 more
doaj +3 more sources
UV-Induced RPA1 Acetylation Promotes Nucleotide Excision Repair
Cell Reports, 2017 Replication protein A (RPA) is a multifunctional, single-stranded DNA-binding protein complex and plays a critical role in DNA replication and damage response.
Hanqing He, Jiajia Wang, Ting Liu
doaj +2 more sources
PCAF/GCN5-Mediated Acetylation of RPA1 Promotes Nucleotide Excision Repair
Cell Reports, 2017 The RPA complex can integrate multiple stress signals into diverse responses by activating distinct DNA repair pathways. However, it remains unclear how RPA1 elects to activate a specific repair pathway during different types of DNA damage.
Meimei Zhao +11 more
doaj +2 more sources
Structural basis of TFIIH activation for nucleotide excision repair
Nature Communications, 2019 The NER machinery contains the multisubunit transcription factor IIH (TFIIH) that opens the DNA repair bubble, scans for the lesion, and coordinates excision of the damaged site.
Goran Kokic +5 more
doaj +2 more sources
Autophagy positively regulates DNA damage recognition by nucleotide excision repair
Autophagy, 2016 Lei Qiang, Yu-Ying He, Palak Shah
exaly +2 more sources
Annual Review of Biochemistry, 2023 Ultraviolet (UV) irradiation and other genotoxic stresses induce bulky DNA lesions, which threaten genome stability and cell viability. Cells have evolved two main repair pathways to remove such lesions: global genome nucleotide excision repair (GG-NER ...
Nicolás Nieto Moreno +2 more
semanticscholar +1 more source
Nucleotide Excision Repair: From Molecular Defects to Neurological Abnormalities
International Journal of Molecular Sciences, 2021 Nucleotide excision repair (NER) is the most versatile DNA repair pathway, which can remove diverse bulky DNA lesions destabilizing a DNA duplex. NER defects cause several autosomal recessive genetic disorders.
Y. Krasikova, N. Rechkunova, O. Lavrik
semanticscholar +1 more source