The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage
Nucleic Acids Research, 2020 The six major mammalian DNA repair pathways were discovered as independent processes, each dedicated to remove specific types of lesions, but the past two decades have brought into focus the significant interplay between these pathways.
Namrata Kumar +2 more
semanticscholar +1 more source
Triple negative breast cancers have a reduced expression of DNA repair genes. [PDF]
PLoS ONE, 2013 DNA repair is a key determinant in the cellular response to therapy and tumor repair status could play an important role in tailoring patient therapy. Our goal was to evaluate the mRNA of 13 genes involved in different DNA repair pathways (base excision,
Enilze Ribeiro +12 more
doaj +1 more source
Role of Nucleotide Excision Repair in Cisplatin Resistance
International Journal of Molecular Sciences, 2020 Cisplatin is a chemotherapeutic drug used for the treatment of a number of cancers. The efficacy of cisplatin relies on its binding to DNA and the induction of cytotoxic DNA damage to kill cancer cells.
Mingrui Duan +3 more
semanticscholar +1 more source
Base Flipping in Nucleotide Excision Repair [PDF]
Journal of Biological Chemistry, 2006 UvrB, the ultimate damage-binding protein in bacterial nucleotide excision repair is capable of binding a vast array of structurally unrelated lesions. A beta-hairpin structure in the protein plays an important role in damage-specific binding. In this paper we have monitored DNA conformational alterations in the UvrB-DNA complex, using the fluorescent ...
Malta, E., Moolenaar, G.F., Goosen, N.
openaire +3 more sources
Hydrogen peroxide induced genomic instability in nucleotide excision repair-deficient lymphoblastoid cells [PDF]
, 2010 Copyright @ 2010 Gopalakrishnan et al; licensee BioMed Central Ltd.Background The Nucleotide Excision Repair (NER) pathway specialises in UV-induced DNA damage repair. Inherited defects in the NER can predispose individuals to Xeroderma Pigmentosum (XP).
Gopalakrishnan, K +14 more
core +1 more source
Molecular mechanism of nucleotide excision repair. [PDF]
Genes & Development, 1999 From its very beginning, life has faced the fundamental problem that the form in which genetic information is stored is not chemically inert. DNA integrity is challenged by the damaging effect of numerous chemical and physical agents, compromizing its function.
W. de Laat, N. Jaspers, J. Hoeijmakers
semanticscholar +4 more sources
Inter-individual variation in nucleotide excision repair in young adults: effects of age, adiposity, micronutrient supplementation and genotype [PDF]
, 2009 Nucleotide excision repair (NER) is responsible for repairing bulky helix-distorting DNA lesions and is essential for the maintenance of genomic integrity.
Mathers, John +6 more
core +1 more source
PLoS ONE, 2012 The many proteins that function in the Fanconi anaemia (FA) monoubiquitylation pathway initiate replicative DNA crosslink repair. However, it is not clear whether individual FA genes participate in DNA repair pathways other than homologous recombination ...
Ian R Kelsall +4 more
doaj +1 more source
REPAIRtoire--a database of DNA repair pathways. [PDF]
, 2010 REPAIRtoire is the first comprehensive database resource for systems biology of DNA damage and repair. The database collects and organizes the following types of information: (i) DNA damage linked to environmental mutagenic and cytotoxic agents, (ii ...
Rother, Kristian +17 more
core +1 more source
The effect of essential oil of basil (Ocimum basilicum L.) on UV-induced mutagenesis in Escherichia coli and Saccharomyces cerevisiae [PDF]
Archives of Biological Sciences, 2008 The antimutagenic potential of essential oil (EO) of basil (Ocimum basilicum L.) and its major constituent linalool were studied with the E. coli K12 and S.cerevisiae D7 assays. In the E.
Stanojević Jasna +5 more
doaj +1 more source