Results 21 to 30 of about 53,532 (260)
PLoS ONE, 2012 The many proteins that function in the Fanconi anaemia (FA) monoubiquitylation pathway initiate replicative DNA crosslink repair. However, it is not clear whether individual FA genes participate in DNA repair pathways other than homologous recombination ...
Ian R Kelsall +4 more
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The effect of essential oil of basil (Ocimum basilicum L.) on UV-induced mutagenesis in Escherichia coli and Saccharomyces cerevisiae [PDF]
Archives of Biological Sciences, 2008 The antimutagenic potential of essential oil (EO) of basil (Ocimum basilicum L.) and its major constituent linalool were studied with the E. coli K12 and S.cerevisiae D7 assays. In the E.
Stanojević Jasna +5 more
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XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair
Nature Communications, 2022 Cells employ global genome nucleotide excision repair to repair a broad spectrum of genomic DNA lesions. Here, the authors reveal how chromatin is primed for repair, providing insight into mechanisms of chromatin plasticity during DNA repair.
Charlotte Blessing +22 more
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SnapShot: Nucleotide Excision Repair
Cell, 2010 Nucleotide excision repair (NER) was discovered in both prokaryotes and eukaryotes in the 1960s (Friedberg et al., 2005). The process corrects a wide spectrum of damage to DNA bases that results in distortions in the native conformation of DNA, including damage induced by ultraviolet (UV) light and by a plethora of chemicals. NER comprises two distinct
Guo, Caixia +2 more
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UV-Induced RPA1 Acetylation Promotes Nucleotide Excision Repair
Cell Reports, 2017 Replication protein A (RPA) is a multifunctional, single-stranded DNA-binding protein complex and plays a critical role in DNA replication and damage response.
Hanqing He, Jiajia Wang, Ting Liu
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Data in Brief, 2016 The global genome nucleotide excision repair factor XPC firstly detects DNA lesions and then recruits a ten-subunit complex TFIIH through binding to the subunit p62 to unwind the damaged DNA for excision repair.
Masahiko Okuda, Yoshifumi Nishimura
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Effects of replication domains on genome-wide UV-induced DNA damage and repair.
PLoS Genetics, 2022 Nucleotide excision repair is the primary repair mechanism that removes UV-induced DNA lesions in placentals. Unrepaired UV-induced lesions could result in mutations during DNA replication. Although the mutagenesis of pyrimidine dimers is reasonably well
Yanchao Huang +7 more
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How chromatin is remodelled during DNA repair of UV-induced DNA damage in Saccharomyces cerevisiae.
PLoS Genetics, 2011 Global genome nucleotide excision repair removes DNA damage from transcriptionally silent regions of the genome. Relatively little is known about the molecular events that initiate and regulate this process in the context of chromatin.
Shirong Yu +3 more
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Nucleotide Excision Repair in Eukaryotes [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Nucleotide excision repair (NER) is the main pathway used by mammals to remove bulky DNA lesions such as those formed by UV light, environmental mutagens, and some cancer chemotherapeutic adducts from DNA. Deficiencies in NER are associated with the extremely skin cancer-prone inherited disorder xeroderma pigmentosum. Although the core NER reaction and
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Navigating the nucleotide excision repair threshold [PDF]
Journal of Cellular Physiology, 2010 AbstractNucleotide excision repair (NER) is the primary DNA repair pathway that removes helix‐distorting DNA strand damage induced by ultraviolet light irradiation or chemical carcinogens to ensure genome integrity. While the core NER proteins that carry out damage recognition, excision, and repair reactions have been identified and extensively ...
Liren, Liu, Jennifer, Lee, Pengbo, Zhou
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