Results 41 to 50 of about 1,102,607 (331)

Functional Characterization of Excision Repair and RecA-Dependent Recombinational DNA Repair in Campylobacter jejuni [PDF]

, 2009
The presence and functionality of DNA repair mechanisms in Campylobacter jejuni are largely unknown. In silico analysis of the complete translated genome of C.
Dep Infectieziekten Immunologie, de Boer, A.G., Graaf-van Bloois, L., van der, Gaasbeek, E.J., Strategic Infection Biology, van Putten, J.P.M., van der Graaf-van Bloois, L., Boer, P., Wagenaar, J.A., Vermaning, B.J., van der Wal, F.J., Wal, F.J., van der, Putten, J.P.M., van, Boer, A.G., de   +13 more
core   +1 more source

Transcription coupled repair and biased insertion of human retrotransposon L1 in transcribed genes

Mobile DNA, 2017
Background L1 retrotransposons inserted within genes in the human genome show a strong bias against sense orientation with respect to the gene. One suggested explanation for this observation was the possibility that L1 inserted randomly, but that there ...
Geraldine Servant, Vincent A. Streva, Prescott L. Deininger   +2 more
doaj   +1 more source

Role of the nucleotide excision repair endonuclease XPF in the kinetoplastid parasite Trypanosoma brucei. [PDF]

Sci Rep
The nucleotide excision repair (NER) mechanism is responsible for removing bulky DNA damage, such as pyrimidine dimers induced by ultraviolet (UV) light.
Gómez-Liñán C, Sáez-Maldonado M, Montosa-Hidalgo L, Ruiz-Pérez LM, González-Pacanowska D, Vidal AE.   +5 more
europepmc   +2 more sources

Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer

Genome Research, 2019
Nucleotide excision repair (NER) is one of the main DNA repair pathways that protect cells against genomic damage. Disruption of this pathway can contribute to the development of cancer and accelerate aging.
M. Jager, F. Blokzijl, E. Kuijk, Johanna Bertl, Maria Vougioukalaki, Roel Janssen, N. Besselink, S. Boymans, J. de Ligt, J. S. Pedersen, J. Hoeijmakers, J. Pothof, R. van Boxtel, E. Cuppen   +13 more
semanticscholar   +1 more source

DNA ADP-Ribosylation Stalls Replication and Is Reversed by RecF-Mediated Homologous Recombination and Nucleotide Excision Repair

Cell Reports, 2020
Summary: ADP-ribosylation of proteins is crucial for fundamental cellular processes. Despite increasing examples of DNA ADP-ribosylation, the impact of this modification on DNA metabolism and cell physiology is unknown. Here, we show that the DarTG toxin-
Emeline Lawarée, Gytis Jankevicius, Charles Cooper, Ivan Ahel, Stephan Uphoff, Christoph M. Tang   +5 more
doaj   +1 more source

Regulation of nucleotide excision repair by nuclear lamin b1. [PDF]

PLoS ONE, 2013
The nuclear lamins play important roles in the structural organization and function of the metazoan cell nucleus. Recent studies on B-type lamins identified a requirement for lamin B1 (LB1) in the regulation of cell proliferation in normal diploid cells.
Veronika Butin-Israeli, Stephen A Adam, Robert D Goldman   +2 more
doaj   +1 more source

Characterisation of XPD from Sulfolobus acidocaldarius : an iron-sulphur cluster containing DNA repair helicase [PDF]

, 2007
DNA is constantly damaged by a variety of exogenous and endogenous sources. To maintain the integrity of the genome, different DNA repair mechanisms have evolved, which deal with different kinds of DNA damage.
Rudolf, Jana
core   +2 more sources

Base and nucleotide excision repair facilitate resolution of platinum drugs-induced transcription blockage

Nucleic Acids Research, 2018
Sensitivity and resistance of cells to platinum drug chemotherapy are to a large extent determined by activity of the DNA damage response (DDR). Combining chemotherapy with inhibition of specific DDR pathways could therefore improve treatment efficacy ...
J. Slyskova, M. Sabatella, C. Ribeiro-Silva, C. Stok, A. Theil, W. Vermeulen, H. Lans   +6 more
semanticscholar   +1 more source

Structural and biochemical analysis of the UvrA binding module of the bacterial transcription repair coupling factor Mfd [PDF]

, 2006
The Mfd (mutation frequency decline) protein is responsible for connecting the cellular processes of transcription and DNA repair in bacteria. Mfd, also termed transcription-repair coupling factor (TRCF), recognizes arrested transcription elongation ...
Aßenmacher, Nora
core   +1 more source

C. elegans survival assays to discern global and transcription-coupled nucleotide excision repair

STAR Protocols, 2021
Summary: Global genome nucleotide excision repair (GG-NER) and transcription-coupled nucleotide excision repair (TC-NER) protect cells against a variety of helix-distorting DNA lesions. In C. elegans, GG-NER primarily acts in proliferative germ cells and
Melanie van der Woude, Hannes Lans
doaj   +1 more source