Results 51 to 60 of about 1,102,607 (331)

Nucleotide excision repair of abasic DNA lesions

open access: yesNucleic Acids Research, 2019
Apurinic/apyrimidinic (AP) sites are a class of highly mutagenic and toxic DNA lesions arising in the genome from a number of exogenous and endogenous sources. Repair of AP lesions takes place predominantly by the base excision pathway (BER).
N. Kitsera   +4 more
semanticscholar   +1 more source

Ribonucleotides as nucleotide excision repair substrates [PDF]

open access: yesDNA Repair, 2014
The incorporation of ribonucleotides in DNA has attracted considerable notice in recent years, since the pool of ribonucleotides can exceed that of the deoxyribonucleotides by at least 10-20-fold, and single ribonucleotide incorporation by DNA polymerases appears to be a common event.
Yuqin, Cai   +2 more
openaire   +2 more sources

Global-genome Nucleotide Excision Repair Controlled by Ubiquitin/Sumo Modifiers

open access: yesFrontiers in Genetics, 2016
Global-genome nucleotide excision repair (GG-NER) prevents genome instability by excising a wide range of structurally unrelated DNA base adducts and crosslinks induced by chemical carcinogens, ultraviolet (UV) radiation or intracellular metabolic by ...
Peter eRuethemann   +2 more
doaj   +1 more source

MOLECULAR BASIS FOR DAMAGE RECOGNITION AND VERIFICATION BY XPC-RAD23B AND TFIIH IN NUCLEOTIDE EXCISION REPAIR

open access: yesDNA Repair, 2018
Global genome nucleotide excision repair (GG-NER) is the main pathway for the removal of bulky lesions from DNA and is characterized by an extraordinarily wide substrate specificity.
Hong Mu   +4 more
semanticscholar   +1 more source

Bacterial DNA excision repair pathways

open access: yesNature Reviews Microbiology, 2022
Bacteria are continuously exposed to numerous endogenous and exogenous DNA-damaging agents. To maintain genome integrity and ensure cell survival, bacteria have evolved several DNA repair pathways to correct different types of DNA damage and non ...
Katherine J. Wozniak, Lyle A. Simmons
semanticscholar   +1 more source

DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers. [PDF]

open access: yes, 2014
Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of ...
Backes, F.J. (Floor)   +999 more
core   +2 more sources

DNA Repair Repertoire of the Enigmatic Hydra

open access: yesFrontiers in Genetics, 2021
Since its discovery by Abraham Trembley in 1744, hydra has been a popular research organism. Features like spectacular regeneration capacity, peculiar tissue dynamics, continuous pattern formation, unique evolutionary position, and an apparent lack of ...
Apurva Barve   +4 more
doaj   +1 more source

Incision aftercare:Nucleotide excision repair after the cut [PDF]

open access: yes, 2023
This thesis focuses on the molecular mechanism of the repair of UV-induced DNA damage through nucleotide excision repair (NER). Specifically the later steps of the mechanism, involving damage removal and repair synthesis, are further ...
van Toorn, Marvin
core   +5 more sources

Genome-wide excision repair in Arabidopsis is coupled to transcription and reflects circadian gene expression patterns

open access: yesNature Communications, 2018
Plants use nucleotide excision repair to maintain genome integrity in response to damage caused by stresses such as UV radiation. Here Oztas et al. use genome-wide profiling to show that excision repair in Arabidopsis is strongly coupled to transcription
Onur Oztas   +3 more
doaj   +1 more source

Genome-wide mapping of nucleotide excision repair with XR-seq

open access: yesNature Protocols, 2018
Nucleotide excision repair is a versatile mechanism to repair a variety of bulky DNA adducts. We developed excision repair sequencing (XR-seq) to study nucleotide excision repair of DNA adducts in humans, mice, Arabidopsis thaliana, yeast and Escherichia
Jin-Chuan Hu   +6 more
semanticscholar   +1 more source

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