SnapShot: Nucleotide Excision Repair
Cell, 2010 Nucleotide excision repair (NER) was discovered in both prokaryotes and eukaryotes in the 1960s (Friedberg et al., 2005). The process corrects a wide spectrum of damage to DNA bases that results in distortions in the native conformation of DNA, including damage induced by ultraviolet (UV) light and by a plethora of chemicals. NER comprises two distinct
Guo, Caixia +2 more
openaire +2 more sources
Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA [PDF]
, 2011 How tightly packed chromatin is thoroughly inspected for DNA damage is one of the fundamental unanswered questions in biology. In particular, the effective excision of carcinogenic lesions caused by the ultraviolet (UV) radiation of sunlight depends on ...
Naegeli, H +35 more
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XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair
Nature Communications, 2022 Cells employ global genome nucleotide excision repair to repair a broad spectrum of genomic DNA lesions. Here, the authors reveal how chromatin is primed for repair, providing insight into mechanisms of chromatin plasticity during DNA repair.
Charlotte Blessing +22 more
doaj +1 more source
Lesion recognition by XPC, TFIIH and XPA in DNA Excision Repair
Nature, 2023 Cryo-electron microscopy structures reveal how XPC recognizes DNA lesions and recruits XPA and the TFIIH core complex for lesion verification in nucleotide excision repair.
Jinseok Kim +8 more
semanticscholar +1 more source
Data in Brief, 2016 The global genome nucleotide excision repair factor XPC firstly detects DNA lesions and then recruits a ten-subunit complex TFIIH through binding to the subunit p62 to unwind the damaged DNA for excision repair.
Masahiko Okuda, Yoshifumi Nishimura
doaj +1 more source
Effects of replication domains on genome-wide UV-induced DNA damage and repair.
PLoS Genetics, 2022 Nucleotide excision repair is the primary repair mechanism that removes UV-induced DNA lesions in placentals. Unrepaired UV-induced lesions could result in mutations during DNA replication. Although the mutagenesis of pyrimidine dimers is reasonably well
Yanchao Huang +7 more
doaj +1 more source
Biochemical characterization and DNA repair pathway interactions of Mag1-mediated base excision repair in Schizosaccharomyces pombe [PDF]
, 2005 The Schizosaccharomyces pombe mag1 gene encodes a DNA repair enzyme with sequence similarity to the AlkA family of DNA glycosylases, which are essential for the removal of cytotoxic alkylation products, the premutagenic deamination product hypoxanthine ...
Alseth, I +6 more
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The helicase XPD unwinds bubble structures and is not stalled by DNA lesions removed by the nucleotide excision repair pathway [PDF]
, 2010 Xeroderma pigmentosum factor D (XPD) is a 5'-3' superfamily 2 helicase and the founding member of a family of DNA helicases with iron-sulphur cluster domains.
Rouillon, Christophe +5 more
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How chromatin is remodelled during DNA repair of UV-induced DNA damage in Saccharomyces cerevisiae.
PLoS Genetics, 2011 Global genome nucleotide excision repair removes DNA damage from transcriptionally silent regions of the genome. Relatively little is known about the molecular events that initiate and regulate this process in the context of chromatin.
Shirong Yu +3 more
doaj +1 more source
Mechanism and regulation of DNA damage recognition in nucleotide excision repair
Genes and Environment, 2019 Nucleotide excision repair (NER) is a versatile DNA repair pathway, which can remove an extremely broad range of base lesions from the genome. In mammalian global genomic NER, the XPC protein complex initiates the repair reaction by recognizing sites of ...
M. Kusakabe +9 more
semanticscholar +1 more source