Results 31 to 40 of about 53,532 (260)
Transcription coupled repair and biased insertion of human retrotransposon L1 in transcribed genes
Mobile DNA, 2017 Background L1 retrotransposons inserted within genes in the human genome show a strong bias against sense orientation with respect to the gene. One suggested explanation for this observation was the possibility that L1 inserted randomly, but that there ...
Geraldine Servant +2 more
doaj +1 more source
Cell Reports, 2020 Summary: ADP-ribosylation of proteins is crucial for fundamental cellular processes. Despite increasing examples of DNA ADP-ribosylation, the impact of this modification on DNA metabolism and cell physiology is unknown. Here, we show that the DarTG toxin-
Emeline Lawarée +5 more
doaj +1 more source
Regulation of nucleotide excision repair by nuclear lamin b1. [PDF]
PLoS ONE, 2013 The nuclear lamins play important roles in the structural organization and function of the metazoan cell nucleus. Recent studies on B-type lamins identified a requirement for lamin B1 (LB1) in the regulation of cell proliferation in normal diploid cells.
Veronika Butin-Israeli +2 more
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C. elegans survival assays to discern global and transcription-coupled nucleotide excision repair
STAR Protocols, 2021 Summary: Global genome nucleotide excision repair (GG-NER) and transcription-coupled nucleotide excision repair (TC-NER) protect cells against a variety of helix-distorting DNA lesions. In C. elegans, GG-NER primarily acts in proliferative germ cells and
Melanie van der Woude, Hannes Lans
doaj +1 more source
Nucleotide excision repair “a legacy of creativity” [PDF]
Mutation Research/DNA Repair, 2001 The first half of the 20th century has seen an enormous growth in our knowledge of DNA repair, in no small part due to the work of Dirk Bootsma, Philip Hanawalt and Bryn Bridges; those honored by this issue. For the new millennium, we have asked three general questions: (A) Do we know all possible strategies of nucleotide excision repair (NER) in all ...
J E, Cleaver +3 more
openaire +2 more sources
Nature Communications, 2018 Plants use nucleotide excision repair to maintain genome integrity in response to damage caused by stresses such as UV radiation. Here Oztas et al. use genome-wide profiling to show that excision repair in Arabidopsis is strongly coupled to transcription
Onur Oztas +3 more
doaj +1 more source
Global-genome Nucleotide Excision Repair Controlled by Ubiquitin/Sumo Modifiers
Frontiers in Genetics, 2016 Global-genome nucleotide excision repair (GG-NER) prevents genome instability by excising a wide range of structurally unrelated DNA base adducts and crosslinks induced by chemical carcinogens, ultraviolet (UV) radiation or intracellular metabolic by ...
Peter eRuethemann +2 more
doaj +1 more source
PCAF/GCN5-Mediated Acetylation of RPA1 Promotes Nucleotide Excision Repair
Cell Reports, 2017 The RPA complex can integrate multiple stress signals into diverse responses by activating distinct DNA repair pathways. However, it remains unclear how RPA1 elects to activate a specific repair pathway during different types of DNA damage.
Meimei Zhao +11 more
doaj +1 more source
Ribonucleotides as nucleotide excision repair substrates [PDF]
DNA Repair, 2014 The incorporation of ribonucleotides in DNA has attracted considerable notice in recent years, since the pool of ribonucleotides can exceed that of the deoxyribonucleotides by at least 10-20-fold, and single ribonucleotide incorporation by DNA polymerases appears to be a common event.
Yuqin, Cai +2 more
openaire +2 more sources
Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice
npj Aging and Mechanisms of Disease, 2020 Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan in multiple organisms including mice. CR was shown to enhance base excision repair and nucleotide excision repair pathways of DNA repair, however, whether CR improves
Zhonghe Ke +4 more
doaj +1 more source