Results 11 to 20 of about 53,532 (260)

Nucleotide excision repair: a versatile and smart toolkit [PDF]

Acta Biochimica et Biophysica Sinica, 2022
Nucleotide excision repair (NER) is a major pathway to deal with bulky adducts induced by various environmental toxins in all cellular organisms. The two sub-pathways of NER, global genome repair (GGR) and transcription-coupled repair (TCR), differ in ...
Zhang Xiping, Yin Mengdie, Hu Jinchuan
doaj   +3 more sources

Epigenetic Regulation of Nucleotide Excision Repair [PDF]

Frontiers in Cell and Developmental Biology, 2022
Genomic DNA is constantly attacked by a plethora of DNA damaging agents both from endogenous and exogenous sources. Nucleotide excision repair (NER) is the most versatile repair pathway that recognizes and removes a wide range of bulky and/or helix ...
Wentao Li, Kyle Jones, Tyler J. Burke, Md Akram Hossain, Leah Lariscy   +4 more
doaj   +4 more sources

Nucleotide excision repair in humans [PDF]

DNA Repair, 2015
The demonstration of DNA damage excision and repair replication by Setlow, Howard-Flanders, Hanawalt and their colleagues in the early 1960s, constituted the discovery of the ubiquitous pathway of nucleotide excision repair (NER). The serial steps in NER are similar in organisms from unicellular bacteria to complex mammals and plants, and involve ...
Graciela Spivak
exaly   +3 more sources

Resistance to Nucleotide Excision Repair of Bulky Guanine Adducts Opposite Abasic Sites in DNA Duplexes and Relationships between Structure and Function. [PDF]

PLoS ONE, 2015
The nucleotide excision repair of certain bulky DNA lesions is abrogated in some specific non-canonical DNA base sequence contexts, while the removal of the same lesions by the nucleotide excision repair mechanism is efficient in duplexes in which all ...
Zhi Liu, Shuang Ding, Konstantin Kropachev, Lei Jia, Shantu Amin, Suse Broyde, Nicholas E Geacintov   +6 more
doaj   +1 more source

Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins

Nature Communications, 2022
Nucleotide excision repair proteins are involved in the repair of UV-induced DNA damage. Here, the authors show that NER proteins, DDB2, XPC, and XPA play a vital role in the 8-oxoguanine repair by coordinating with base excision repair protein OGG1.
Namrata Kumar, Arjan F. Theil, Vera Roginskaya, Yasmin Ali, Michael Calderon, Simon C. Watkins, Ryan P. Barnes, Patricia L. Opresko, Alex Pines, Hannes Lans, Wim Vermeulen, Bennett Van Houten   +11 more
doaj   +1 more source

Nucleotide excision repair genes shaping embryonic development [PDF]

Open Biology, 2019
Nucleotide excision repair (NER) is a highly conserved mechanism to remove helix-distorting DNA lesions. A major substrate for NER is DNA damage caused by environmental genotoxins, most notably ultraviolet radiation.
Sofia J. Araújo, Isao Kuraoka
doaj   +1 more source

Prokaryotic Nucleotide Excision Repair [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
Nucleotide excision repair (NER) has allowed bacteria to flourish in many different niches around the globe that inflict harsh environmental damage to their genetic material. NER is remarkable because of its diverse substrate repertoire, which differs greatly in chemical composition and structure.
Caroline, Kisker, Jochen, Kuper, Bennett, Van Houten   +2 more
openaire   +2 more sources

Triple negative breast cancers have a reduced expression of DNA repair genes. [PDF]

PLoS ONE, 2013
DNA repair is a key determinant in the cellular response to therapy and tumor repair status could play an important role in tailoring patient therapy. Our goal was to evaluate the mRNA of 13 genes involved in different DNA repair pathways (base excision,
Enilze Ribeiro, Monica Ganzinelli, Daniele Andreis, Ramona Bertoni, Roberto Giardini, Stephen B Fox, Massimo Broggini, Alberto Bottini, Vanessa Zanoni, Letizia Bazzola, Chiara Foroni, Daniele Generali, Giovanna Damia   +12 more
doaj   +1 more source

Ubiquitin and TFIIH-stimulated DDB2 dissociation drives DNA damage handover in nucleotide excision repair

Nature Communications, 2020
DNA damage sensors DDB2 and XPC are fundamental factors to initiate global genome nucleotide excision repair and protect DNA from mutagenesis. Here the authors reveal that ubiquitin and TFIIH-stimulated DDB2 dissociation promotes DNA damage handover to ...
Cristina Ribeiro-Silva, Mariangela Sabatella, Angela Helfricht, Jurgen A. Marteijn, Arjan F. Theil, Wim Vermeulen, Hannes Lans   +6 more
doaj   +1 more source

Base Flipping in Nucleotide Excision Repair [PDF]

Journal of Biological Chemistry, 2006
UvrB, the ultimate damage-binding protein in bacterial nucleotide excision repair is capable of binding a vast array of structurally unrelated lesions. A beta-hairpin structure in the protein plays an important role in damage-specific binding. In this paper we have monitored DNA conformational alterations in the UvrB-DNA complex, using the fluorescent ...
Malta, E., Moolenaar, G.F., Goosen, N.
openaire   +3 more sources