Results 61 to 70 of about 1,102,607 (331)
Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins
Nature Communications, 2021 Many genetic diseases are caused by single-nucleotide polymorphisms. Base editors can correct these mutations at single-nucleotide resolution, but until recently, only allowed for transition edits, addressing four out of twelve possible DNA base ...
Liwei Chen +7 more
semanticscholar +1 more source
Nucleotide excision repair “a legacy of creativity” [PDF]
Mutation Research/DNA Repair, 2001 The first half of the 20th century has seen an enormous growth in our knowledge of DNA repair, in no small part due to the work of Dirk Bootsma, Philip Hanawalt and Bryn Bridges; those honored by this issue. For the new millennium, we have asked three general questions: (A) Do we know all possible strategies of nucleotide excision repair (NER) in all ...
J E, Cleaver +3 more
openaire +2 more sources
Nucleotide excision repair in the test tube. [PDF]
, 1995 The eukaryotic nucleotide excision-repair pathway has been reconstituted in vitro, an achievement that should hasten the full enzymological characterization of this highly complex DNA-repair ...
Hoeijmakers, J.H.J. (Jan) +1 more
core +1 more source
Base Sequence Context Effects on Nucleotide Excision Repair
Journal of Nucleic Acids, 2010 Nucleotide excision repair (NER) plays a critical role in maintaining the integrity of the genome when damaged by bulky DNA lesions, since inefficient repair can cause mutations and human diseases notably cancer. The structural properties of DNA lesions
Yuqin Cai +3 more
doaj +1 more source
Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice
npj Aging and Mechanisms of Disease, 2020 Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan in multiple organisms including mice. CR was shown to enhance base excision repair and nucleotide excision repair pathways of DNA repair, however, whether CR improves
Zhonghe Ke +4 more
doaj +1 more source
Nucleotide excision repair (NER) is a potential therapeutic target in multiple myeloma
Leukemia, 2017 Despite the development of novel drugs, alkylating agents remain an important component of therapy in multiple myeloma (MM). DNA repair processes contribute towards sensitivity to alkylating agents and therefore we here evaluate the role of nucleotide ...
R. Szalat +19 more
semanticscholar +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Emerging Roles of Post-Translational Modifications in Nucleotide Excision Repair
Cells, 2020 Nucleotide excision repair (NER) is a versatile DNA repair pathway which can be activated in response to a broad spectrum of UV-induced DNA damage, such as bulky adducts, including cyclobutane-pyrimidine dimers (CPDs) and 6–4 photoproducts (6–4PPs ...
Barbara N. Borsos +2 more
doaj +1 more source
Communications Biology, 2022 Reconstitution of D radiodurans nucleotide excision repair provides insights into the kinetics of repair on different DNA substrates and determines the order and precise sites of incisions on the 5’ and 3’ sides of the lesion.
Anna Seck +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Chemical alterations in DNA induced by genotoxic factors can have a complex nature such as bulky DNA adducts, interstrand DNA cross-links (ICLs), and clustered DNA lesions (including double-strand breaks, DSB).
Yeldar Baiken +10 more
doaj +1 more source