Results 51 to 60 of about 59,918 (258)

Structural basis for APE1 processing DNA damage in the nucleosome

Nature Communications, 2022
AP endonuclease 1 (APE1) processes genomic AP sites during base excision repair. Here, the authors determine the structural mechanism used by APE1 to process nucleosomal AP sites, providing new insight into DNA repair in chromatin.
Tyler M. Weaver, Nicole M. Hoitsma, Jonah J. Spencer, Lokesh Gakhar, Nicholas J. Schnicker, Bret D. Freudenthal   +5 more
doaj   +1 more source

Bridging the Gap in Neuroblastoma Care: Consensus‐Based Statements With Recommendations for Improved Patient and Caregiver Experiences

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neuroblastoma's complex, heterogeneous biology poses significant diagnostic and therapeutic challenges, often requiring caregivers to absorb complex information and participate in time‐sensitive decisions. However, caregivers often feel unprepared to evaluate options.
Vickie Buenger, Joseph Bauer, Jennifer Diamond, Maggie Fader, Shae Hansen, Jacqueline M. Kraveka, Johanna Schoen, Amber Shearer, Dena Sherwood   +8 more
wiley   +1 more source

Transcriptional coupling (Mfd) and DNA damage scanning (DisA) coordinate excision repair events for efficient Bacillus subtilis spore outgrowth

MicrobiologyOpen, 2018
The absence of base excision repair (BER) proteins involved in processing ROS‐promoted genetic insults activates a DNA damage scanning (DisA)‐dependent checkpoint event in outgrowing Bacillus subtilis spores.
Luz I. Valenzuela‐García, Víctor M. Ayala‐García, Ana G. Regalado‐García, Peter Setlow, Mario Pedraza‐Reyes   +4 more
doaj   +1 more source

Phase Angle as an Early Functional Biomarker of Cancer‐Related Fatigue in Pediatric Oncology: A Prospective Longitudinal Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric cancer remains a leading cause of morbidity and mortality worldwide, particularly in low‐and middle‐income countries. Cancer treatment may impair nutritional status, alter body composition, and exacerbate cancer‐related fatigue (CRF).
Luís Carlos Lopes‐Junior, Luiz Claudio Barreto Silva Neto, Fabiano Kenji Haraguchi, Letícia Batista de Azevedo, Marcelo Brenner Nascimento Carlini, Raphael Manhães Pessanha, Mariana Rabello Laignier, Wesley Rocha Grippa, Tania Mara Lopes Bitti Bortolini, Gláucia Zouain‐Figueiredo, Regina Aparecida Garcia de Lima, Liliana Vasquez   +11 more
wiley   +1 more source

Cerebrospinal Fluid Leak in Transnasal Transsphenoidal Surgery for Pituitary Adenoma and its Management

Bengal Journal of Otolaryngology and Head Neck Surgery, 2021
Introduction Over the past few decades endoscopic transnasal transsphenoidal (ETNTS) approach has been practised for excision of pituitary tumours which has minimised the rate of complications and morbidity.
Sanajeet Singh, ravi roy, Vaibhav A Chandankhede, Sunil Goyal, M S Sridhar, D K Gupta   +5 more
doaj  

Searching for DNA Damage: Insights From Single Molecule Analysis

Frontiers in Molecular Biosciences, 2021
DNA is under constant threat of damage from a variety of chemical and physical insults, such as ultraviolet rays produced by sunlight and reactive oxygen species produced during respiration or inflammation.
Matthew A. Schaich, Matthew A. Schaich, Bennett Van Houten, Bennett Van Houten, Bennett Van Houten   +4 more
doaj   +1 more source

Development and Implementation of a Disease‐Targeted Storybook as a Clinical Tool for Children With Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Although significant progress has been made in childhood leukemia survival, healthcare providers, and caregivers often face challenges in explaining this disease to patients. Disease‐targeted storybooks have been proposed as a tool to facilitate the understanding of diagnoses and treatment.
Nutvipha Ummartyotin, Usanarat Anurathapan, Rawiwan Roongpraiwan, Potchanee Dandamrongrak, Siriporn Nakhonchai, Pawin Numthavaj, Vilawan Chirdkiatgumchai   +6 more
wiley   +1 more source

Chemical Biology of Mammalian DNA Repair

CHIMIA, 2001
Damage to the heterocyclic bases of DNA in the genome is mainly corrected by the base excision repair (BER) or nucleotide excision repair (NER) pathways.
Orlando D. Schärer
doaj   +2 more sources

Decline of DNA damage response along with myogenic differentiation

Life Science Alliance
In postmitotic myotubes, DNA repair processes such as Base Excision Repair, and Non-Homologous End Joining are weakened compared with the proliferative precursors myoblasts. DNA integrity is incessantly confronted to agents inducing DNA lesions.
Haser H Sutcu, Phoebe Rassinoux, Lise-Marie Donnio, Damien Neuillet, François Vianna, Olivier Gabillot, Pierre-Olivier Mari, Céline Baldeyron, Giuseppina Giglia-Mari   +8 more
doaj   +1 more source

The Base Excision Repair Pathway in the Nematode Caenorhabditis elegans

Frontiers in Cell and Developmental Biology, 2020
Exogenous and endogenous damage to the DNA is inevitable. Several DNA repair pathways including base excision, nucleotide excision, mismatch, homologous and non-homologous recombinations are conserved across all organisms to faithfully maintain the ...
Noha Elsakrmy, Qiu-Mei Zhang-Akiyama, Dindial Ramotar   +2 more
doaj   +1 more source