Results 51 to 60 of about 4,636,913 (295)

Lethal and mutagenic properties of MMS-generated DNA lesions in Escherichia coli cells deficient in BER and AlkB-directed DNA repair. [PDF]

, 2010
Methylmethane sulphonate (MMS), an S(N)2-type alkylating agent, generates DNA methylated bases exhibiting cytotoxic and mutagenic properties. Such damaged bases can be removed by a system of base excision repair (BER) and by oxidative DNA demethylation ...
Sikora, Anna, Grzesiuk, Elzbieta, A. Sikora, J. Nieminuszczy, Mielecki, Damian, D. Mielecki, A. Chojnacka, Nieminuszczy, Jadwiga, Wrzesiński, Michał, M. Wrzesinski, E. Grzesiuk, Chojnacka, Aleksandra   +11 more
core   +1 more source

GENETIC POLYMORPHISM OF APE1 ASP148GLU IS NOT ASSOCIATED WITH BLADDER CANCER RISK IN A TURKISH POPULATION

Sabiad, 2023
Objective: The purpose of this investigative research was to investigatethe potential impact of a single nucleotide polymorphism (Asp148Glu) within the APE1 gene on the development of bladder cancer (BCa) andspread, and to investigate the interaction of ...
Taghi Ahmadi Rendi, Serhat Kılınç, Selçuk Erdem, Enes Değirmenci, Mehmet Öner Şanlı, Canan Küçükgergin, Semra Doğru Abbasoğlu   +6 more
doaj   +1 more source

The helicase XPD unwinds bubble structures and is not stalled by DNA lesions removed by the nucleotide excision repair pathway [PDF]

, 2010
Xeroderma pigmentosum factor D (XPD) is a 5'-3' superfamily 2 helicase and the founding member of a family of DNA helicases with iron-sulphur cluster domains.
Rouillon, Christophe, Schwarz-Linek, Ulrich, Rudolf, Jana, White, Malcolm F, Schwarz-Linek, Ulrich; id_orcid, White, Malcolm F; id_orcid   +5 more
core   +1 more source

Mitochondrial DNA Damage and Histological Features in Liver Tissue of Azoxymethane-Treated Apex1 Haploinsufficient Mice

Biomolecules
Mitochondrial dysfunction and loss of mitochondrial DNA (mtDNA) integrity are increasingly recognized as key contributors to liver diseases such as cirrhosis and hepatocellular carcinoma.
Carmen M. Pérez-Pérez, Adlin Rodríguez-Muñoz, Gerardo G. Mackenzie, Karen E. Matsukuma, María R. Castro-Achi, Sylvette Ayala-Peña, Carlos A. Torres-Ramos   +6 more
doaj   +1 more source

Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice

npj Aging and Mechanisms of Disease, 2020
Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan in multiple organisms including mice. CR was shown to enhance base excision repair and nucleotide excision repair pathways of DNA repair, however, whether CR improves
Zhonghe Ke, Denis Firsanov, Brianna Spencer, Andrei Seluanov, Vera Gorbunova   +4 more
doaj   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Base-Excision-Repair-Induced Construction of a Single Quantum-Dot-Based Sensor for Sensitive Detection of DNA Glycosylase Activity

, 2016
DNA glycosylase is an initiating enzyme of cellular base excision repair pathway which is responsible for the repair of various DNA lesions and the maintenance of genomic stability, and the dysregulation of DNA glycosylase activity is associated with a ...
Fei Ma (719371), Bo Tang (23472), Li-juan Wang (1606234), Chun-yang Zhang (1405213)   +3 more
core   +1 more source

Initiating base excision repair in chromatin [PDF]

DNA Repair, 2018
The base excision repair (BER) pathway removes modified nucleobases that can be deleterious to an organism. BER is initiated by a glycosylase, which finds and removes these modified nucleobases. Most of the characterization of glycosylase activity has been conducted in the context of DNA oligomer substrates.
Erin E, Kennedy, Paul J, Caffrey, Sarah, Delaney   +2 more
openaire   +2 more sources

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Biomolecular Simulation of Base Excision Repair and Protein Signaling [PDF]

, 2006
The goal of the Biomolecular Simulation of Base Excision Repair and Protein Signaling project is to enhance our understanding of the mechanism of human polymerase-, one of the key enzymes in base excision repair (BER) and the cell-signaling enzymes ...
Straatsma, TP, Vorpagel, Erich R., Smith, Paul E., McCammon, J. A., Wong, Chung F., Zacharias, Martin W., Miller, John H.   +6 more
core   +1 more source