Results 71 to 80 of about 112,601 (234)
MicrobiologyOpen, 2018 The absence of base excision repair (BER) proteins involved in processing ROS‐promoted genetic insults activates a DNA damage scanning (DisA)‐dependent checkpoint event in outgrowing Bacillus subtilis spores.
Luz I. Valenzuela‐García +4 more
doaj +1 more source
Initiating base excision repair in chromatin [PDF]
DNA Repair, 2018 The base excision repair (BER) pathway removes modified nucleobases that can be deleterious to an organism. BER is initiated by a glycosylase, which finds and removes these modified nucleobases. Most of the characterization of glycosylase activity has been conducted in the context of DNA oligomer substrates.
Erin E, Kennedy +2 more
openaire +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Bengal Journal of Otolaryngology and Head Neck Surgery, 2021 Introduction Over the past few decades endoscopic transnasal transsphenoidal (ETNTS) approach has been practised for excision of pituitary tumours which has minimised the rate of complications and morbidity.
Sanajeet Singh +5 more
doaj
Triple negative breast cancers have a reduced expression of DNA repair genes. [PDF]
PLoS ONE, 2013 DNA repair is a key determinant in the cellular response to therapy and tumor repair status could play an important role in tailoring patient therapy. Our goal was to evaluate the mRNA of 13 genes involved in different DNA repair pathways (base excision,
Enilze Ribeiro +12 more
doaj +1 more source
Update on Poly-ADP-ribose polymerase inhibition for ovarian cancer treatment [PDF]
, 2016 Background: Despite standard treatment for epithelial ovarian cancer (EOC), that involves cytoreductive surgery followed by platinum-based chemotherapy, and initial high response rates to these, up to 80 % of patients experience relapses with a median ...
Caruso, Davide +4 more
core +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Chemical Biology of Mammalian DNA Repair
CHIMIA, 2001 Damage to the heterocyclic bases of DNA in the genome is mainly corrected by the base excision repair (BER) or nucleotide excision repair (NER) pathways.
Orlando D. Schärer
doaj +2 more sources
Decline of DNA damage response along with myogenic differentiation
Life Science AllianceIn postmitotic myotubes, DNA repair processes such as Base Excision Repair, and Non-Homologous End Joining are weakened compared with the proliferative precursors myoblasts. DNA integrity is incessantly confronted to agents inducing DNA lesions.
Haser H Sutcu +8 more
doaj +1 more source
The Base Excision Repair Pathway in the Nematode Caenorhabditis elegans
Frontiers in Cell and Developmental Biology, 2020 Exogenous and endogenous damage to the DNA is inevitable. Several DNA repair pathways including base excision, nucleotide excision, mismatch, homologous and non-homologous recombinations are conserved across all organisms to faithfully maintain the ...
Noha Elsakrmy +2 more
doaj +1 more source