Results 71 to 80 of about 64,997 (303)

Cerebrospinal Fluid Leak in Transnasal Transsphenoidal Surgery for Pituitary Adenoma and its Management

Bengal Journal of Otolaryngology and Head Neck Surgery, 2021
Introduction Over the past few decades endoscopic transnasal transsphenoidal (ETNTS) approach has been practised for excision of pituitary tumours which has minimised the rate of complications and morbidity.
Sanajeet Singh, ravi roy, Vaibhav A Chandankhede, Sunil Goyal, M S Sridhar, D K Gupta   +5 more
doaj  

Triple negative breast cancers have a reduced expression of DNA repair genes. [PDF]

PLoS ONE, 2013
DNA repair is a key determinant in the cellular response to therapy and tumor repair status could play an important role in tailoring patient therapy. Our goal was to evaluate the mRNA of 13 genes involved in different DNA repair pathways (base excision,
Enilze Ribeiro, Monica Ganzinelli, Daniele Andreis, Ramona Bertoni, Roberto Giardini, Stephen B Fox, Massimo Broggini, Alberto Bottini, Vanessa Zanoni, Letizia Bazzola, Chiara Foroni, Daniele Generali, Giovanna Damia   +12 more
doaj   +1 more source

DNA polymerase B deficiency is linked to aggressive breast cancer: a comprehensive analysis of gene copy number, mRNA and protein expression in multiple cohorts

, 2014
Short arm of chromosome 8 is a hot spot for chromosomal breaks, losses and amplifications in breast cancer. Although such genetic changes may have phenotypic consequences, the identity of candidate gene(s) remains to be clearly defined.
Albarakati, N, Russell, R, Moseley, P, Moseley, Paul, Agarwal, D, Agarwal, Devika, Abdel-Fatah, TMA, Caldas, C, Abayomi, Michael Ayotunde, Chan, S, Ellis, IO, Russell, Roslin, Chan, Stephen, Madhusudan, Srinivasan, Abayomi, M, Ball, G, Perry, C, Madhusudan, S, Albarakati, Nada, Ball, Graham, Abdel-Fatah, Tarek M.A., Ellis, Ian O., Caldas, Carlos, Perry, Christina   +23 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Chemical Biology of Mammalian DNA Repair

CHIMIA, 2001
Damage to the heterocyclic bases of DNA in the genome is mainly corrected by the base excision repair (BER) or nucleotide excision repair (NER) pathways.
Orlando D. Schärer
doaj   +2 more sources

Decline of DNA damage response along with myogenic differentiation

Life Science Alliance
In postmitotic myotubes, DNA repair processes such as Base Excision Repair, and Non-Homologous End Joining are weakened compared with the proliferative precursors myoblasts. DNA integrity is incessantly confronted to agents inducing DNA lesions.
Haser H Sutcu, Phoebe Rassinoux, Lise-Marie Donnio, Damien Neuillet, François Vianna, Olivier Gabillot, Pierre-Olivier Mari, Céline Baldeyron, Giuseppina Giglia-Mari   +8 more
doaj   +1 more source

The Base Excision Repair Pathway in the Nematode Caenorhabditis elegans

Frontiers in Cell and Developmental Biology, 2020
Exogenous and endogenous damage to the DNA is inevitable. Several DNA repair pathways including base excision, nucleotide excision, mismatch, homologous and non-homologous recombinations are conserved across all organisms to faithfully maintain the ...
Noha Elsakrmy, Qiu-Mei Zhang-Akiyama, Dindial Ramotar   +2 more
doaj   +1 more source

Structural and biochemical analysis of the UvrA binding module of the bacterial transcription repair coupling factor Mfd [PDF]

, 2006
The Mfd (mutation frequency decline) protein is responsible for connecting the cellular processes of transcription and DNA repair in bacteria. Mfd, also termed transcription-repair coupling factor (TRCF), recognizes arrested transcription elongation ...
Aßenmacher, Nora
core  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

RAS transformation requires CUX1-dependent repair of oxidative DNA damage.

PLoS Biology, 2014
The Cut homeobox 1 (CUX1) gene is a target of loss-of-heterozygosity in many cancers, yet elevated CUX1 expression is frequently observed and is associated with shorter disease-free survival.
Zubaidah M Ramdzan, Charles Vadnais, Ranjana Pal, Guillaume Vandal, Chantal Cadieux, Lam Leduy, Sayeh Davoudi, Laura Hulea, Lu Yao, Anthony N Karnezis, Marilène Paquet, David Dankort, Alain Nepveu   +12 more
doaj   +1 more source