Results 81 to 90 of about 4,636,913 (295)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Insights into genotoxic effects of electromagnetic fields [PDF]

, 2008
The increasing use of appliances, which generate electromagnetic fields (EMFs), has provoked public concern about their safety. Scientific research into possible health effects however produced conflicting results.
Focke, Frauke
core   +1 more source

Cerebrospinal Fluid Leak in Transnasal Transsphenoidal Surgery for Pituitary Adenoma and its Management

Bengal Journal of Otolaryngology and Head Neck Surgery, 2021
Introduction Over the past few decades endoscopic transnasal transsphenoidal (ETNTS) approach has been practised for excision of pituitary tumours which has minimised the rate of complications and morbidity.
Sanajeet Singh, ravi roy, Vaibhav A Chandankhede, Sunil Goyal, M S Sridhar, D K Gupta   +5 more
doaj  

Exploiting DNA repair defects in triple negative breast cancer to improve cell killing

Therapeutic Advances in Medical Oncology, 2020
Background: The lack of molecular targets for triple negative breast cancer (TNBC) has limited treatment options and reduced survivorship. Identifying new molecular targets may help improve patient survival and decrease recurrence and metastasis.
Kevin J. Lee, Elise Mann, Griffin Wright, Cortt G. Piett, Zachary D. Nagel, Natalie R. Gassman   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The role of base excision repair genes polymorphisms [PDF]

, 2017
The authors gratefully acknowledge all patients and controls who generously participated in the present study. Our appreciation and thanks are extended to laboratory technicians, Mrs. Luisa Manso Oliveira, Mrs.
Fernando Lima, Ana P. Azevedo, Esmeraldina Júnior, Lima, João P. de, Júnior, Esmeraldina, Lima, Fernando, Rueff, Jose, João P. De Lima, Azevedo, Ana P, José Rueff, Silva, Susana N, Susana N. Silva, Azevedo, Ana P., Silva, Susana N., de Lima, João P, Reichert, Alice, Alice Reichert   +16 more
core   +1 more source

Chemical Biology of Mammalian DNA Repair

CHIMIA, 2001
Damage to the heterocyclic bases of DNA in the genome is mainly corrected by the base excision repair (BER) or nucleotide excision repair (NER) pathways.
Orlando D. Schärer
doaj   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Decline of DNA damage response along with myogenic differentiation

Life Science Alliance
In postmitotic myotubes, DNA repair processes such as Base Excision Repair, and Non-Homologous End Joining are weakened compared with the proliferative precursors myoblasts. DNA integrity is incessantly confronted to agents inducing DNA lesions.
Haser H Sutcu, Phoebe Rassinoux, Lise-Marie Donnio, Damien Neuillet, François Vianna, Olivier Gabillot, Pierre-Olivier Mari, Céline Baldeyron, Giuseppina Giglia-Mari   +8 more
doaj   +1 more source

RAS transformation requires CUX1-dependent repair of oxidative DNA damage.

PLoS Biology, 2014
The Cut homeobox 1 (CUX1) gene is a target of loss-of-heterozygosity in many cancers, yet elevated CUX1 expression is frequently observed and is associated with shorter disease-free survival.
Zubaidah M Ramdzan, Charles Vadnais, Ranjana Pal, Guillaume Vandal, Chantal Cadieux, Lam Leduy, Sayeh Davoudi, Laura Hulea, Lu Yao, Anthony N Karnezis, Marilène Paquet, David Dankort, Alain Nepveu   +12 more
doaj   +1 more source