Results 1 to 10 of about 376,771 (302)
Understanding Active Photoprotection: DNA-Repair Enzymes and Antioxidants [PDF]
LifeThe detrimental effects of ultraviolet radiation (UVR) on human skin are well-documented, encompassing DNA damage, oxidative stress, and an increased risk of carcinogenesis.
Emilio Garcia-Mouronte +3 more
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Comet assay to measure DNA repair: approach and applications. [PDF]
Frontiers in Genetics, 2014 Cellular repair enzymes remove virtually all DNA damage before it is fixed; repair therefore plays a crucial role in preventing cancer. Repair studied at the level of transcription correlates poorly with enzyme activity, and so assays of phenotype are ...
Amaya eAzqueta +4 more
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Folding-upon-Repair DNA Nanoswitches for Monitoring the Activity of DNA Repair Enzymes. [PDF]
Angew Chem Int Ed Engl, 2021 AbstractWe present a new class of DNA‐based nanoswitches that, upon enzymatic repair, could undergo a conformational change mechanism leading to a change in fluorescent signal. Such folding‐upon‐repair DNA nanoswitches are synthetic DNA sequences containing O6‐methyl‐guanine (O6‐MeG) nucleobases and labelled with a fluorophore/quencher optical pair ...
Farag N +7 more
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DNA repair enzymes of the Antarctic Dry Valley metagenome [PDF]
Frontiers in Microbiology, 2023 Microbiota inhabiting the Dry Valleys of Antarctica are subjected to multiple stressors that can damage deoxyribonucleic acid (DNA) such as desiccation, high ultraviolet light (UV) and multiple freeze-thaw cycles.
Elizabeth Rzoska-Smith +4 more
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Endogenous DNA Damage and Repair Enzymes
Genomics, Proteomics & Bioinformatics, 2016 Tomas Lindahl completed his medical studies at Karolinska Institute in 1970. Yet, his work has always been dedicated to unraveling fundamental mechanisms of DNA decay and DNA repair.
Arne Klungland, Yun-Gui Yang
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The effect of dimeric bisbenzimidazoles on the activity of DNA repair enzymes TDP1, TDP2, PARP1 and PARP2 [PDF]
Вавиловский журнал генетики и селекцииOncological diseases remain a leading cause of pathological mortality worldwide, making the development of anticancer drugs a critical focus in medicinal chemistry.
N. S. Dyrkheeva +10 more
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Dysregulation of the DNA damage response by phosphorothioate antisense oligonucleotides [PDF]
Nature CommunicationsPhosphorothioate (PS)-modified antisense oligonucleotides (ASOs) are widely used to modulate gene expression in basic research and therapy. Within cells, these ASOs seed nuclear structures with unclear functions and consequences.
Linn Hjelmgren +9 more
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Six critical questions for DNA repair enzymes in skincare products: a review in dialog [PDF]
Clinical, Cosmetic and Investigational Dermatology, 2019 Daniel B Yarosh,1 Amanda Rosenthal,2,3 Ronald Moy31Daniel B Yarosh Inc., Merrick, NY, USA; 2Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, FL, USA; 3Research Department, Moy-Fincher-Chipps Facial Plastics/Dermatology ...
Yarosh DB, Rosenthal A, Moy R
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Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein
eLife, 2021 BLM (Bloom syndrome protein) is a RECQ-family helicase involved in the dissolution of complex DNA structures and repair intermediates. Synthetic lethality analysis implicates BLM as a promising target in a range of cancers with defects in the DNA damage ...
Xiangrong Chen +13 more
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mBio, 2021 Human papillomaviruses are causative agents in around 5% of all cancers, with no specific antiviral therapeutics available for treating infections or resultant cancers.
Apurva T. Prabhakar +16 more
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