Results 1 to 10 of about 2,604,485 (241)
Understanding Active Photoprotection: DNA-Repair Enzymes and Antioxidants [PDF]
LifeThe detrimental effects of ultraviolet radiation (UVR) on human skin are well-documented, encompassing DNA damage, oxidative stress, and an increased risk of carcinogenesis.
Emilio Garcia-Mouronte +3 more
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DNA repair enzymes of the Antarctic Dry Valley metagenome [PDF]
Frontiers in Microbiology, 2023 Microbiota inhabiting the Dry Valleys of Antarctica are subjected to multiple stressors that can damage deoxyribonucleic acid (DNA) such as desiccation, high ultraviolet light (UV) and multiple freeze-thaw cycles.
Elizabeth Rzoska-Smith +4 more
doaj +2 more sources
Six critical questions for DNA repair enzymes in skincare products: a review in dialog [PDF]
Clinical, Cosmetic and Investigational Dermatology, 2019 Daniel B Yarosh,1 Amanda Rosenthal,2,3 Ronald Moy31Daniel B Yarosh Inc., Merrick, NY, USA; 2Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, FL, USA; 3Research Department, Moy-Fincher-Chipps Facial Plastics/Dermatology ...
Yarosh DB, Rosenthal A, Moy R
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Folding‐upon‐Repair DNA Nanoswitches for Monitoring the Activity of DNA Repair Enzymes [PDF]
Angewandte Chemie - International Edition, 2021 Rosa Merlo +2 more
exaly +2 more sources
Aldehyde Detoxification in Cancer: Metabolic Guardians of the Genome [PDF]
BiomoleculesReactive aldehydes are potent electrophiles that damage DNA and can ultimately promote cancer. While many aldehydes are ubiquitous in the environment, mammalian metabolism also generates high levels of endogenous aldehydes sufficient to threaten genome ...
Brandon T. James +2 more
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DNA repair enzymes in sunscreens and their impact on photoageing—A systematic review [PDF]
Photodermatology Photoimmunology and Photomedicine, 2020 Hanna Luze, Iris Zalaudek
exaly +2 more sources
Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein
eLife, 2021 BLM (Bloom syndrome protein) is a RECQ-family helicase involved in the dissolution of complex DNA structures and repair intermediates. Synthetic lethality analysis implicates BLM as a promising target in a range of cancers with defects in the DNA damage ...
Xiangrong Chen +13 more
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mBio, 2021 Human papillomaviruses are causative agents in around 5% of all cancers, with no specific antiviral therapeutics available for treating infections or resultant cancers.
Apurva T. Prabhakar +16 more
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The Domino Effect: Nucleosome Dynamics and the Regulation of Base Excision Repair Enzymes
DNA, 2022 DNA damage is induced by exogenous and endogenous sources, creating a variety of lesions. However, the cellular repair machinery that addresses and corrects this damage must contend with the fact that genomic DNA is sequestered in the nucleoprotein ...
Julia C. Cook, Sarah Delaney
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eLife, 2019 Coordination of the cellular response to DNA damage is organised by multi-domain ‘scaffold’ proteins, including 53BP1 and TOPBP1, which recognise post-translational modifications such as phosphorylation, methylation and ubiquitylation on other proteins ...
Nicolas Bigot +5 more
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