Results 41 to 50 of about 376,771 (302)

DNA-repair enzyme turns to translation

Nature, 2020
A key DNA-repair enzyme has a surprising role during the early steps in the assembly of ribosomes — the molecular machines that translate the genetic code into protein.
openaire   +2 more sources

Conformational Dynamics of Biopolymers in the Course of Their Interaction: Multifaceted Approaches to the Analysis by the Stopped-Flow Technique with Fluorescence Detection

Photonics, 2023
This review deals with modern approaches to systematic research on molecular-kinetic mechanisms of damage recognition and removal by pro- and eukaryotic enzymes of DNA base excision repair.
Nikita A. Kuznetsov
doaj   +1 more source

HMGB1 Stimulates Activity of Polymerase β on Nucleosome Substrates [PDF]

, 2017
The process of base excision repair (BER) recognizes and repairs small lesions or inappropriate bases on DNA through either a short-patch or long-patch pathway.
Balakrishnan, Lata, Balliano, Angela, Hao, Fanfan, Hayes, Jeffrey J., Njeri, Catherine   +4 more
core   +2 more sources

Archaeal DNA Repair Mechanisms

Biomolecules, 2020
Archaea often thrive in environmental extremes, enduring levels of heat, pressure, salinity, pH, and radiation that prove intolerable to most life. Many environmental extremes raise the propensity for DNA damaging events and thus, impact DNA stability ...
Craig J. Marshall, Thomas J. Santangelo
doaj   +1 more source

Ribonucleolytic resection is required for repair of strand displaced nonhomologous end-joining intermediates [PDF]

, 2013
Nonhomologous end-joining (NHEJ) pathways repair DNA double-strand breaks (DSBs) in eukaryotes and many prokaryotes, although it is not reported to operate in the third domain of life, archaea. Here, we describe a complete NHEJ complex, consisting of DNA
Bartlett, Edward, Brissett, Nigel C, Doherty, Aidan J   +2 more
core   +1 more source

HIV-1 Vpr Reprograms CLR4^DCAF1 E3 Ubiquitin Ligase to Antagonize Exonuclease 1-Mediated Restriction of HIV-1 Infection

mBio, 2018
Viral accessory proteins hijack host cell E3 ubiquitin ligases to antagonize innate/intrinsic defenses and thereby provide a more permissive environment for virus replication.
Junpeng Yan, Ming-Chieh Shun, Caili Hao, Yi Zhang, Juan Qian, Kasia Hrecka, Maria DeLucia, Christina Monnie, Jinwoo Ahn, Jacek Skowronski   +9 more
doaj   +1 more source

Biochemical Aspects of Genetics [PDF]

, 1965
It would be impossible, in the time and space available, to cover all of the noteworthy advances that have been made in biochemical genetics during the past year.
Horowitz, N. H., Metzenberg, Robert L.
core   +1 more source

The nexus of vitamin homeostasis and DNA synthesis and modification in mammalian brain [PDF]

, 2014
The purpose of this review is to discuss the implications of the 2009 discovery of the sixth deoxyribonucleoside (dN) [5-hydroxymethyldeoxycytidine (hmdC)] in DNA which is the most abundant in neurons.
Conrad E Johanson, Reynold Spector
core   +1 more source

Fumarase affects the deoxyribonucleic acid damage response by protecting the mitochondrial desulfurase Nfs1p from modification and inactivation

iScience, 2021
Summary: The Krebs cycle enzyme fumarase, which has been identified as a tumor suppressor, is involved in the deoxyribonucleic acid (DNA) damage response (DDR) in human, yeast, and bacterial cells.
Joyce Yip, Suqing Wang, Jasper Tan, Teck Kwang Lim, Qingsong Lin, Zhang Yu, Ofri Karmon, Ophry Pines, Norbert Lehming   +8 more
doaj   +1 more source

Elevated Level of DNA Damage and Impaired Repair of Oxidative DNA Damage in Patients with Recurrent Depressive Disorder [PDF]

, 2015
Background: Depressive disorder (DD), including recurrent DD (rDD), is a severe psychological disease, which affects a large percentage of the world population.
Bielecka-Kowalska, Anna, Czarny, Piotr, Gałecki, Piotr, Kacperska, Dagmara, Kawczyńska, Daria, Kwiatkowski, Dominik, Orzechowska, Agata, Szemraj, Janusz, Talarowska, Monika, Śliwiński, Tomasz   +9 more
core   +1 more source