Results 21 to 30 of about 219,333 (243)
A Versatile Scaffold Contributes to Damage Survival via Sumoylation and Nuclease Interactions
Cell Reports, 2014 Summary: DNA repair scaffolds mediate specific DNA and protein interactions in order to assist repair enzymes in recognizing and removing damaged sequences. Many scaffold proteins are dedicated to repairing a particular type of lesion. Here, we show that
Prabha Sarangi +9 more
doaj +1 more source
PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2
Nature Communications, 2016 Chromosomal single-strand DNA breaks occur frequently and require repair to avoid disease outcomes. Here, the authors show that in bird cells, PARP3 accelerates this repair, and use structural biology and cell biology techniques to reveal details of the ...
Gabrielle J. Grundy +12 more
doaj +1 more source
Targeting the DNA damage response and repair in cancer through nucleotide metabolism
Molecular Oncology, 2022 The exploitation of the DNA damage response and DNA repair proficiency of cancer cells is an important anticancer strategy. The replication and repair of DNA are dependent upon the supply of deoxynucleoside triphosphate (dNTP) building blocks, which are ...
Thomas Helleday, Sean G. Rudd
doaj +1 more source
Medycyna Pracy, 2018 Genetic polymorphism is associated with the occurrence of at least 2 different alleles in the locus with a frequency higher than 1% in the population.
Karol Bukowski, Katarzyna Woźniak
doaj +1 more source
Photonics, 2023 This review deals with modern approaches to systematic research on molecular-kinetic mechanisms of damage recognition and removal by pro- and eukaryotic enzymes of DNA base excision repair.
Nikita A. Kuznetsov
doaj +1 more source
mBio, 2018 Viral accessory proteins hijack host cell E3 ubiquitin ligases to antagonize innate/intrinsic defenses and thereby provide a more permissive environment for virus replication.
Junpeng Yan +9 more
doaj +1 more source
Archaeal DNA Repair Mechanisms
Biomolecules, 2020 Archaea often thrive in environmental extremes, enduring levels of heat, pressure, salinity, pH, and radiation that prove intolerable to most life. Many environmental extremes raise the propensity for DNA damaging events and thus, impact DNA stability ...
Craig J. Marshall, Thomas J. Santangelo
doaj +1 more source
DNA-repair enzyme turns to translation
Nature, 2020 A key DNA-repair enzyme has a surprising role during the early steps in the assembly of ribosomes — the molecular machines that translate the genetic code into protein.
openaire +2 more sources
Charge-transport-mediated recruitment of DNA repair enzymes [PDF]
The Journal of Chemical Physics, 2008 Damaged or mismatched bases in DNA can be repaired by base excision repair enzymes (BER) that replace the defective base. Although the detailed molecular structures of many BER enzymes are known, how they colocalize to lesions remains unclear. One hypothesis involves charge transport (CT) along DNA [Yavin et al., Proc. Natl. Acad. Sci. U.S.A. 102, 3546
Fok, Pak-Wing, Guo, Chin-Lin, Chou, Tom
openaire +4 more sources
iScience, 2021 Summary: The Krebs cycle enzyme fumarase, which has been identified as a tumor suppressor, is involved in the deoxyribonucleic acid (DNA) damage response (DDR) in human, yeast, and bacterial cells.
Joyce Yip +8 more
doaj +1 more source