Evaluating the efficacy of DNA repair biomarkers to assess human cell response to chemotherapy using imaging flow cytometry [PDF]
, 2013 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Chemotherapy and radiotherapy are widely accepted as common forms of treatment for cancers. The majority of cancer patients receive chemotherapy alone or in
Zahir, Sheba Adam
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Deciphering the interstrand crosslink DNA repair network expressed by Trypanosoma brucei [PDF]
, 2019 Interstrand crosslinks (ICLs) represent a highly toxic form of DNA damage that can block essential biological processes including DNA replication and transcription.
Dittani, A, WILKINSON, S
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PLoS ONE, 2011 Host DNA repair enzymes have long been assumed to play a role in HIV replication, and many different DNA repair factors have been associated with HIV.
Amy S Espeseth +6 more
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Repair of DNA interstrand crosslinks as a mechanism of clinical resistance to melphalan in multiple myeloma [PDF]
, 2002 Melphalan is widely used as a preparative agent in patients with multiple myeloma (MM) undergoing autologous stem cell transplantation (SCT). Although disease relapse is the major cause of death after a melphalan-conditioned autograft, the mechanism ...
Mahendra, P +11 more
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Comet assay to measure DNA repair: approach and applications.
Frontiers in Genetics, 2014 Cellular repair enzymes remove virtually all DNA damage before it is fixed; repair therefore plays a crucial role in preventing cancer. Repair studied at the level of transcription correlates poorly with enzyme activity, and so assays of phenotype are ...
Amaya eAzqueta +4 more
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Complementary anti-cancer pathways triggered by inhibition of sideroflexin 4 in ovarian cancer
Scientific Reports, 2022 DNA damaging agents are a mainstay of standard chemotherapy for ovarian cancer. Unfortunately, resistance to such DNA damaging agents frequently develops, often due to increased activity of DNA repair pathways.
Lia Tesfay +9 more
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Characterisation of XPD from Sulfolobus acidocaldarius : an iron-sulphur cluster containing DNA repair helicase [PDF]
, 2007 DNA is constantly damaged by a variety of exogenous and endogenous sources. To maintain the integrity of the genome, different DNA repair mechanisms have evolved, which deal with different kinds of DNA damage.
Rudolf, Jana
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Endogenous DNA Damage and Repair Enzymes
Genomics, Proteomics & Bioinformatics, 2016 Tomas Lindahl completed his medical studies at Karolinska Institute in 1970. Yet, his work has always been dedicated to unraveling fundamental mechanisms of DNA decay and DNA repair.
Arne Klungland, Yun-Gui Yang
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A Versatile Scaffold Contributes to Damage Survival via Sumoylation and Nuclease Interactions
Cell Reports, 2014 Summary: DNA repair scaffolds mediate specific DNA and protein interactions in order to assist repair enzymes in recognizing and removing damaged sequences. Many scaffold proteins are dedicated to repairing a particular type of lesion. Here, we show that
Prabha Sarangi +9 more
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PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2
Nature Communications, 2016 Chromosomal single-strand DNA breaks occur frequently and require repair to avoid disease outcomes. Here, the authors show that in bird cells, PARP3 accelerates this repair, and use structural biology and cell biology techniques to reveal details of the ...
Gabrielle J. Grundy +12 more
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