Results 21 to 30 of about 225,059 (304)

ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX

Cell Reports, 2015
53BP1 plays multiple roles in mammalian DNA damage repair, mediating pathway choice and facilitating DNA double-strand break repair in heterochromatin. Although it possesses a C-terminal BRCT2 domain, commonly involved in phospho-peptide binding in other
Robert A. Baldock, Matthew Day, Oliver J. Wilkinson, Ross Cloney, Penelope A. Jeggo, Antony W. Oliver, Felicity Z. Watts, Laurence H. Pearl   +7 more
doaj   +1 more source

Study of interaction of antimutagenic 1,4-dihydropyridine AV-153-Na with DNA-damaging molecules and its impact on DNA repair activity [PDF]

PeerJ, 2018
Background 1,4-dihydropyridines (1,4-DHP) possesses important biochemical and pharmacological properties, including antioxidant and antimutagenic activities. It was shown that the antimutagenic 1,4-dihydropyridine AV-153-Na interacts with DNA. The aim of
Elina Leonova, Evita Rostoka, Sylvie Sauvaigo, Larisa Baumane, Turs Selga, Nikolajs Sjakste   +5 more
doaj   +2 more sources

Specialized interfaces of Smc5/6 control hinge stability and DNA association

Nature Communications, 2017
Structural Maintenance of Chromosomes (SMC) complexes maintain genome integrity by regulating the segregation of chromosomes. Here, Altet al. describe the structure of the heterodimeric Smc5/6-hinge from fission yeast and define functional features ...
Aaron Alt, Hung Q. Dang, Owen S. Wells, Luis M. Polo, Matt A. Smith, Grant A. McGregor, Thomas Welte, Alan R. Lehmann, Laurence H. Pearl, Johanne M. Murray, Antony W. Oliver   +10 more
doaj   +1 more source

siRNA screening of a targeted library of DNA repair factors in HIV infection reveals a role for base excision repair in HIV integration.

PLoS ONE, 2011
Host DNA repair enzymes have long been assumed to play a role in HIV replication, and many different DNA repair factors have been associated with HIV.
Amy S Espeseth, Rick Fishel, Daria Hazuda, Qian Huang, Min Xu, Kristine Yoder, Honglin Zhou   +6 more
doaj   +1 more source

DNAtraffic--a new database for systems biology of DNA dynamics during the cell life. [PDF]

, 2011
DNAtraffic (http://dnatraffic.ibb.waw.pl/) is dedicated to be a unique comprehensive and richly annotated database of genome dynamics during the cell life.
Barszcz, Daniela, Pomorski, Pawel, Krwawicz, Joanna, Grzesiuk, Elzbieta, P. Pomorski, D. Barszcz, E. Grzesiuk, K. Kuchta, Kuchta, Krzysztof, J. Krwawicz   +9 more
core   +1 more source

Comet assay to measure DNA repair: approach and applications.

Frontiers in Genetics, 2014
Cellular repair enzymes remove virtually all DNA damage before it is fixed; repair therefore plays a crucial role in preventing cancer. Repair studied at the level of transcription correlates poorly with enzyme activity, and so assays of phenotype are ...
Amaya eAzqueta, Jana eSlyskova, Sabine A.S. Langie, Isabel O'Neill Gaivão, Andrew R. Collins   +4 more
doaj   +1 more source

Complementary anti-cancer pathways triggered by inhibition of sideroflexin 4 in ovarian cancer

Scientific Reports, 2022
DNA damaging agents are a mainstay of standard chemotherapy for ovarian cancer. Unfortunately, resistance to such DNA damaging agents frequently develops, often due to increased activity of DNA repair pathways.
Lia Tesfay, Bibbin T. Paul, Poornima Hegde, Molly Brewer, Samrin Habbani, Evan Jellison, Timothy Moore, Hao Wu, Suzy V. Torti, Frank M. Torti   +9 more
doaj   +1 more source

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2

Nature Communications, 2016
Chromosomal single-strand DNA breaks occur frequently and require repair to avoid disease outcomes. Here, the authors show that in bird cells, PARP3 accelerates this repair, and use structural biology and cell biology techniques to reveal details of the ...
Gabrielle J. Grundy, Luis M. Polo, Zhihong Zeng, Stuart L. Rulten, Nicolas C. Hoch, Pathompong Paomephan, Yingqi Xu, Steve M. Sweet, Alan W. Thorne, Antony W. Oliver, Steve J. Matthews, Laurence H. Pearl, Keith W. Caldecott   +12 more
doaj   +1 more source

A Versatile Scaffold Contributes to Damage Survival via Sumoylation and Nuclease Interactions

Cell Reports, 2014
Summary: DNA repair scaffolds mediate specific DNA and protein interactions in order to assist repair enzymes in recognizing and removing damaged sequences. Many scaffold proteins are dedicated to repairing a particular type of lesion. Here, we show that
Prabha Sarangi, Veronika Altmannova, Cory Holland, Zdenka Bartosova, Fanfan Hao, Dorothea Anrather, Gustav Ammerer, Sang Eun Lee, Lumir Krejci, Xiaolan Zhao   +9 more
doaj   +1 more source

Targeting the DNA damage response and repair in cancer through nucleotide metabolism

Molecular Oncology, 2022
The exploitation of the DNA damage response and DNA repair proficiency of cancer cells is an important anticancer strategy. The replication and repair of DNA are dependent upon the supply of deoxynucleoside triphosphate (dNTP) building blocks, which are ...
Thomas Helleday, Sean G. Rudd
doaj   +1 more source