Results 11 to 20 of about 2,604,485 (241)

Biochemical characterization and DNA repair pathway interactions of Mag1-mediated base excision repair in Schizosaccharomyces pombe [PDF]

, 2005
The Schizosaccharomyces pombe mag1 gene encodes a DNA repair enzyme with sequence similarity to the AlkA family of DNA glycosylases, which are essential for the removal of cytotoxic alkylation products, the premutagenic deamination product hypoxanthine ...
Alseth, I, Whitby, MC, Bjoras, M, Korvald, H, Tsaneva, I, Bjørås, M, Whitby, Matthew, Seeberg, E, Osman, F   +8 more
core   +1 more source

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands

eLife, 2018
TOPBP1 and its fission yeast homologue Rad4, are critical players in a range of DNA replication, repair and damage signalling processes. They are composed of multiple BRCT domains, some of which bind phosphorylated motifs in other proteins. They thus act
Matthew Day, Mathieu Rappas, Katie Ptasinska, Dominik Boos, Antony W Oliver, Laurence H Pearl   +5 more
doaj   +1 more source

Functional Characterization of Excision Repair and RecA-Dependent Recombinational DNA Repair in Campylobacter jejuni [PDF]

, 2009
The presence and functionality of DNA repair mechanisms in Campylobacter jejuni are largely unknown. In silico analysis of the complete translated genome of C.
Dep Infectieziekten Immunologie, de Boer, A.G., Graaf-van Bloois, L., van der, Gaasbeek, E.J., Strategic Infection Biology, van Putten, J.P.M., van der Graaf-van Bloois, L., Boer, P., Wagenaar, J.A., Vermaning, B.J., van der Wal, F.J., Wal, F.J., van der, Putten, J.P.M., van, Boer, A.G., de   +13 more
core   +2 more sources

Resolving DNA Damage: Epigenetic Regulation of DNA Repair

Molecules, 2020
Epigenetic research has rapidly evolved into a dynamic field of genome biology. Chromatin regulation has been proved to be an essential aspect for all genomic processes, including DNA repair.
Panagiotis Karakaidos, Dimitris Karagiannis, Theodoros Rampias   +2 more
doaj   +1 more source

A function of thymine DNA glycosylase-initiated DNA repair in maintaining epigenome stability [PDF]

, 2013
The Thymine DNA Glycosylase (TDG) was initially discovered by its ability to excise the deamination products of cytosine and 5-methylcytosine (5-mC), and therefore thought to initiate base excision repair (BER) of the resulting G•U and G•T mismatches.
Jacobs, Angelika L.
core   +1 more source

REPAIRtoire--a database of DNA repair pathways. [PDF]

, 2010
REPAIRtoire is the first comprehensive database resource for systems biology of DNA damage and repair. The database collects and organizes the following types of information: (i) DNA damage linked to environmental mutagenic and cytotoxic agents, (ii ...
Rother, Kristian, K. Poleszak, Papaj, Grzegorz, E. Osinska, Bujnicki, Janusz M, Lesiak, Justyna, G. Papaj, J. Lesiak, Milanowska, Kaja, J. Krwawicz, Kosinski, Jan, K. Rother, Krwawicz, Joanna, K. Milanowska, Poleszak, Katarzyna, Osinska, Ewelina, J. Kosinski, J. M. Bujnicki   +17 more
core   +1 more source

ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX

Cell Reports, 2015
53BP1 plays multiple roles in mammalian DNA damage repair, mediating pathway choice and facilitating DNA double-strand break repair in heterochromatin. Although it possesses a C-terminal BRCT2 domain, commonly involved in phospho-peptide binding in other
Robert A. Baldock, Matthew Day, Oliver J. Wilkinson, Ross Cloney, Penelope A. Jeggo, Antony W. Oliver, Felicity Z. Watts, Laurence H. Pearl   +7 more
doaj   +1 more source

Study of interaction of antimutagenic 1,4-dihydropyridine AV-153-Na with DNA-damaging molecules and its impact on DNA repair activity [PDF]

PeerJ, 2018
Background 1,4-dihydropyridines (1,4-DHP) possesses important biochemical and pharmacological properties, including antioxidant and antimutagenic activities. It was shown that the antimutagenic 1,4-dihydropyridine AV-153-Na interacts with DNA. The aim of
Elina Leonova, Evita Rostoka, Sylvie Sauvaigo, Larisa Baumane, Turs Selga, Nikolajs Sjakste   +5 more
doaj   +2 more sources

FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain [PDF]

, 2014
FAN1 is a structure-selective DNA repair nuclease with 5' flap endonuclease activity, involved in the repair of interstrand DNA crosslinks. It is the only eukaryotic protein with a virus-type replication-repair nuclease ("VRR-Nuc") "module" that commonly
David M.J. Lilley, Anne-Cécile Déclais, Déclais, Anne-Cécile, Simon Pennell, Pennell, Simon, Ian A. Taylor, Smerdon, Stephen J., Lilley, David M.J., Haire, Lesley F., José W. Saldanha, Berg, Wioletta, Saldanha, José W., Jiejin Li, Wioletta Berg, Li, Jiejin, Déclais, Anne-Cécile; id_orcid, Lilley, David M J, Lilley, David M. J.; id_orcid, Saldanha, José W, Taylor, Ian A., Stephen J. Smerdon, Haire, Lesley F, Rouse, John, Taylor, Ian A, John Rouse, Lesley F. Haire, Smerdon, Stephen J; id_orcid   +26 more
core   +1 more source

Specialized interfaces of Smc5/6 control hinge stability and DNA association

Nature Communications, 2017
Structural Maintenance of Chromosomes (SMC) complexes maintain genome integrity by regulating the segregation of chromosomes. Here, Altet al. describe the structure of the heterodimeric Smc5/6-hinge from fission yeast and define functional features ...
Aaron Alt, Hung Q. Dang, Owen S. Wells, Luis M. Polo, Matt A. Smith, Grant A. McGregor, Thomas Welte, Alan R. Lehmann, Laurence H. Pearl, Johanne M. Murray, Antony W. Oliver   +10 more
doaj   +1 more source