Results 11 to 20 of about 219,333 (243)
Annual Review of Biochemistry, 1982 The invention relates to methods of selection of agents and compositions for the treatment of proliferative diseases such as cancer. More specifically, the present invention relates to the methods of selecting compounds which modulate the activity of DNA repair enzymes HAB1 and HAB2 and their uses in the treatment of disorders, which would benefit from
openaire +2 more sources
eLife, 2018 TOPBP1 and its fission yeast homologue Rad4, are critical players in a range of DNA replication, repair and damage signalling processes. They are composed of multiple BRCT domains, some of which bind phosphorylated motifs in other proteins. They thus act
Matthew Day +5 more
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Resolving DNA Damage: Epigenetic Regulation of DNA Repair
Molecules, 2020 Epigenetic research has rapidly evolved into a dynamic field of genome biology. Chromatin regulation has been proved to be an essential aspect for all genomic processes, including DNA repair.
Panagiotis Karakaidos +2 more
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DNA damage by peroxynitrite characterized with DNA repair enzymes [PDF]
Nucleic Acids Research, 1996 The DNA damage induced by peroxynitrite in isolated bacteriophage PM2 DNA was characterized by means of several repair enzymes with defined substrate specificities. Similar results were obtained with peroxynitrite itself and with 3-morpholinosydnonimine (SIN-1), a compound generating the precursors of peroxynitrite, nitric oxide and superoxide.
B, Epe +4 more
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Cell Reports, 2015 53BP1 plays multiple roles in mammalian DNA damage repair, mediating pathway choice and facilitating DNA double-strand break repair in heterochromatin. Although it possesses a C-terminal BRCT2 domain, commonly involved in phospho-peptide binding in other
Robert A. Baldock +7 more
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Study of interaction of antimutagenic 1,4-dihydropyridine AV-153-Na with DNA-damaging molecules and its impact on DNA repair activity [PDF]
PeerJ, 2018 Background 1,4-dihydropyridines (1,4-DHP) possesses important biochemical and pharmacological properties, including antioxidant and antimutagenic activities. It was shown that the antimutagenic 1,4-dihydropyridine AV-153-Na interacts with DNA. The aim of
Elina Leonova +5 more
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Specialized interfaces of Smc5/6 control hinge stability and DNA association
Nature Communications, 2017 Structural Maintenance of Chromosomes (SMC) complexes maintain genome integrity by regulating the segregation of chromosomes. Here, Altet al. describe the structure of the heterodimeric Smc5/6-hinge from fission yeast and define functional features ...
Aaron Alt +10 more
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PLoS ONE, 2011 Host DNA repair enzymes have long been assumed to play a role in HIV replication, and many different DNA repair factors have been associated with HIV.
Amy S Espeseth +6 more
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Comet assay to measure DNA repair: approach and applications.
Frontiers in Genetics, 2014 Cellular repair enzymes remove virtually all DNA damage before it is fixed; repair therefore plays a crucial role in preventing cancer. Repair studied at the level of transcription correlates poorly with enzyme activity, and so assays of phenotype are ...
Amaya eAzqueta +4 more
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Complementary anti-cancer pathways triggered by inhibition of sideroflexin 4 in ovarian cancer
Scientific Reports, 2022 DNA damaging agents are a mainstay of standard chemotherapy for ovarian cancer. Unfortunately, resistance to such DNA damaging agents frequently develops, often due to increased activity of DNA repair pathways.
Lia Tesfay +9 more
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