Results 31 to 40 of about 2,604,485 (241)

Targeting the DNA damage response and repair in cancer through nucleotide metabolism

Molecular Oncology, 2022
The exploitation of the DNA damage response and DNA repair proficiency of cancer cells is an important anticancer strategy. The replication and repair of DNA are dependent upon the supply of deoxynucleoside triphosphate (dNTP) building blocks, which are ...
Thomas Helleday, Sean G. Rudd
doaj   +1 more source

DNA repair by photolyases

, 2021
Photolyases belong to the cryptochrome/photolyase protein family (CPF) which perform different functions such as DNA repair, circadian photoreceptor, and transcriptional regulation.
Kavakli, Ibrahim Halil, Ozturk, Nuri, Gul, Şeref   +2 more
core   +1 more source

Splitting, joining and cutting : mechanistic studies of enzymes that manipulate DNA [PDF]

, 2010
Electronic version does not contain associated previously published materialDNA is a reactive and dynamic molecule that is continually damaged by both exogenous and endogenous agents.
McRobbie, Anne-Marie M.
core   +2 more sources

Polymorphism of genes encoding proteins of DNA repair vs. occupational and environmental exposure to lead, arsenic and pesticides

Medycyna Pracy, 2018
Genetic polymorphism is associated with the occurrence of at least 2 different alleles in the locus with a frequency higher than 1% in the population.
Karol Bukowski, Katarzyna Woźniak
doaj   +1 more source

Conformational Dynamics of Biopolymers in the Course of Their Interaction: Multifaceted Approaches to the Analysis by the Stopped-Flow Technique with Fluorescence Detection

Photonics, 2023
This review deals with modern approaches to systematic research on molecular-kinetic mechanisms of damage recognition and removal by pro- and eukaryotic enzymes of DNA base excision repair.
Nikita A. Kuznetsov
doaj   +1 more source

DNA repair in bacteroides fragilis [PDF]

, 2008
Includes abstract.Includes bibliographical leaves (leaves 89-101).Bacteroides fragilis is a gut commensal in both humans and animals where it benefits the host through metabolizing indigestible compounds, stimulating the immune system and protecting ...
Steffens, Laura Sione
core   +1 more source

HIV-1 Vpr Reprograms CLR4^DCAF1 E3 Ubiquitin Ligase to Antagonize Exonuclease 1-Mediated Restriction of HIV-1 Infection

mBio, 2018
Viral accessory proteins hijack host cell E3 ubiquitin ligases to antagonize innate/intrinsic defenses and thereby provide a more permissive environment for virus replication.
Junpeng Yan, Ming-Chieh Shun, Caili Hao, Yi Zhang, Juan Qian, Kasia Hrecka, Maria DeLucia, Christina Monnie, Jinwoo Ahn, Jacek Skowronski   +9 more
doaj   +1 more source

Archaeal DNA Repair Mechanisms

Biomolecules, 2020
Archaea often thrive in environmental extremes, enduring levels of heat, pressure, salinity, pH, and radiation that prove intolerable to most life. Many environmental extremes raise the propensity for DNA damaging events and thus, impact DNA stability ...
Craig J. Marshall, Thomas J. Santangelo
doaj   +1 more source

DNAtraffic--a new database for systems biology of DNA dynamics during the cell life. [PDF]

, 2011
DNAtraffic (http://dnatraffic.ibb.waw.pl/) is dedicated to be a unique comprehensive and richly annotated database of genome dynamics during the cell life.
Barszcz, Daniela, Pomorski, Pawel, Krwawicz, Joanna, Grzesiuk, Elzbieta, P. Pomorski, D. Barszcz, E. Grzesiuk, K. Kuchta, Kuchta, Krzysztof, J. Krwawicz   +9 more
core   +1 more source

Endonuclease V-Mediated Deoxyinosine Excision Repair in Vitro

, 2011
Deoxyinosine (dI) in DNA can arise from hydrolytic or nitrosative deamination of deoxyadenosine It is excised in a -repair pathway that is initiated by endonuclease V.
楊雅倩;林淑萍;高照村;蔡克嵩;方偉宏, YANG, YA-CHIEN;STEVEN, D. GOODMAN;LIN, SHWU-BIN;KAO, JAU-TSUEN;TSAI, KEH-SUNG;FANG, WOEI-HORNG   +1 more
core   +1 more source