Results 31 to 40 of about 376,771 (302)

Complementary anti-cancer pathways triggered by inhibition of sideroflexin 4 in ovarian cancer

Scientific Reports, 2022
DNA damaging agents are a mainstay of standard chemotherapy for ovarian cancer. Unfortunately, resistance to such DNA damaging agents frequently develops, often due to increased activity of DNA repair pathways.
Lia Tesfay, Bibbin T. Paul, Poornima Hegde, Molly Brewer, Samrin Habbani, Evan Jellison, Timothy Moore, Hao Wu, Suzy V. Torti, Frank M. Torti   +9 more
doaj   +1 more source

Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics [PDF]

, 2016
Therapeutic manipulation of the gasotransmitter hydrogen sulfide (H(2)S) has recently been proposed as a novel targeted anticancer approach. Here we show that human lung adenocarcinoma tissue expresses high levels of hydrogen sulfide (H(2)S) producing ...
Druzhyna, Nadiya, Hellmich, Mark R., Marcatti, Michela, Nagy, Péter, Szabo, Csaba, Szczesny, Bartosz, Wiktorowicz, John E., Zatarain, John R.   +7 more
core   +1 more source

Enzyme Structures: DNA repair flips out [PDF]

Current Biology, 1995
New insights into the workings of the repair enzymes that police the genome for damage to DNA come from the recently determined structures of two uracil-DNA glycosylases.
openaire   +2 more sources

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2

Nature Communications, 2016
Chromosomal single-strand DNA breaks occur frequently and require repair to avoid disease outcomes. Here, the authors show that in bird cells, PARP3 accelerates this repair, and use structural biology and cell biology techniques to reveal details of the ...
Gabrielle J. Grundy, Luis M. Polo, Zhihong Zeng, Stuart L. Rulten, Nicolas C. Hoch, Pathompong Paomephan, Yingqi Xu, Steve M. Sweet, Alan W. Thorne, Antony W. Oliver, Steve J. Matthews, Laurence H. Pearl, Keith W. Caldecott   +12 more
doaj   +1 more source

A Versatile Scaffold Contributes to Damage Survival via Sumoylation and Nuclease Interactions

Cell Reports, 2014
Summary: DNA repair scaffolds mediate specific DNA and protein interactions in order to assist repair enzymes in recognizing and removing damaged sequences. Many scaffold proteins are dedicated to repairing a particular type of lesion. Here, we show that
Prabha Sarangi, Veronika Altmannova, Cory Holland, Zdenka Bartosova, Fanfan Hao, Dorothea Anrather, Gustav Ammerer, Sang Eun Lee, Lumir Krejci, Xiaolan Zhao   +9 more
doaj   +1 more source

Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair [PDF]

, 2018
The error-free and efficient repair of DNA double-stranded breaks (DSBs) is extremely important for cell survival. RNA has been implicated in the resolution of DNA damage but the mechanism remains poorly understood.
A Adamo, A Brambati, A Ciccia, A Dhir, A Kozomara, A Wilczynska, AD Herbert, AE Hall, B Adamson, B Langmead, BR Hawley, C Chailleux, C Cotta-Ramusino, C Escribano-Diaz, C Zierhut, D Miki, E Hatchi, E White, F Aymard, F Aymard, F Rossiello, G Meister, H Keskin, H Li, HA Meijer, I Schmidts, J Pak, JR Chapman, JS Iacovoni, KM Michalik, L Dai, L Feng, L Li, M Gao, M Groh, M Lobrich, M Zimmermann, MI Love, MJ Hangauer, MJ Marzi, ML Garcia-Rubio, MS Kumar, N Gromak, NL Bray, P Chakraborty, P Xu, PA Ginno, Q Wang, Q Yang, R Yi, RA Baldock, S Anders, S Bekker-Jensen, S Britton, S Britton, S Francia, S Francia, S Kawai, S Matsuoka, SE Castel, SF Bunting, T Sijen, W Wei, Y Zhou, YY Leung   +64 more
core   +3 more sources

Targeting the DNA damage response and repair in cancer through nucleotide metabolism

Molecular Oncology, 2022
The exploitation of the DNA damage response and DNA repair proficiency of cancer cells is an important anticancer strategy. The replication and repair of DNA are dependent upon the supply of deoxynucleoside triphosphate (dNTP) building blocks, which are ...
Thomas Helleday, Sean G. Rudd
doaj   +1 more source

DNA Charge Transport within the Cell [PDF]

, 2015
The unique characteristics of DNA charge transport (CT) have prompted an examination of roles for this chemistry within a biological context. Not only can DNA CT facilitate long-range oxidative damage of DNA, but redox-active proteins can couple to the ...
Barton, Jacqueline K., Grodick, Michael A., Muren, Natalie B.   +2 more
core   +1 more source

Label-free electrochemical monitoring of DNA ligase activity [PDF]

, 2008
This study presents a simple, label-free electrochemical technique for the monitoring of DNA ligase activity. DNA ligases are enzymes that catalyze joining of breaks in the backbone of DNA and are of significant scientific interest due to their essential
Ahel I., Bellamy S. R., Borodina T. A., Bullard D. R., Cahova-Kucharikova K., Cao W. G., Doherty A. J., Fadrna R., Fojta M., Fojta M., Fojta M., Fojta M., Fojta M., Fojta M., Friedberg E. C., Gowers D. M., Heiter D. F., Kucharikova K., Liu L. F., Palecek E., Pascal J. M., Rass U., Schrock R. D., Scott B. O. S., Shuman S., Tomkinson A. E., Vacek J., Wilkinson A., Wilkinson A., Zauner G.   +29 more
core   +1 more source

Polymorphism of genes encoding proteins of DNA repair vs. occupational and environmental exposure to lead, arsenic and pesticides

Medycyna Pracy, 2018
Genetic polymorphism is associated with the occurrence of at least 2 different alleles in the locus with a frequency higher than 1% in the population.
Karol Bukowski, Katarzyna Woźniak
doaj   +1 more source