Results 31 to 40 of about 225,059 (304)

The fanconi anemia DNA repair pathway is regulated by an interaction between ubiquitin and the E2-like fold domain of FANCL [PDF]

, 2015
The Fanconi Anemia (FA) DNA repair pathway is essential for the recognition and repair of DNA interstrand crosslinks (ICL). Inefficient repair of these ICL can lead to leukemia and bone marrow failure.
Howard, Mark J., Sidhu, Ateesh, Chaugule, Viduth K., Alpi, Arno F., Miles, Jennifer A., Carroll, Eilis, Frost, Mark G., Rowe, Michelle L., Walden, Helen   +8 more
core   +1 more source

Polymorphism of genes encoding proteins of DNA repair vs. occupational and environmental exposure to lead, arsenic and pesticides

Medycyna Pracy, 2018
Genetic polymorphism is associated with the occurrence of at least 2 different alleles in the locus with a frequency higher than 1% in the population.
Karol Bukowski, Katarzyna Woźniak
doaj   +1 more source

DNA-repair enzyme turns to translation

Nature, 2020
A key DNA-repair enzyme has a surprising role during the early steps in the assembly of ribosomes — the molecular machines that translate the genetic code into protein.
openaire   +2 more sources

Human RECQL5{beta} stimulates flap endonuclease 1 [PDF]

, 2010
Human RECQL5 is a member of the RecQ helicase family which is implicated in genome maintenance. Five human members of the family have been identified; three of them, BLM, WRN and RECQL4 are associated with elevated cancer risk. RECQL1 and RECQL5 have not
Dawut, Lale, Wang, Z, Hedayati, Mohammad, Hedayati, M, Croteau, Deborah L, Speina, Elzbieta, Speina, E, Janscak, Pavel, Bohr, Vilhelm A, May, Alfred, Croteau, D L, Schwendener, Sybille, Janscak, Pavel; https://orcid.org/, May, A, Dawut, L, Schwendener, S, Wang, Zhengming, Bohr, V A   +17 more
core   +1 more source

Conformational Dynamics of Biopolymers in the Course of Their Interaction: Multifaceted Approaches to the Analysis by the Stopped-Flow Technique with Fluorescence Detection

Photonics, 2023
This review deals with modern approaches to systematic research on molecular-kinetic mechanisms of damage recognition and removal by pro- and eukaryotic enzymes of DNA base excision repair.
Nikita A. Kuznetsov
doaj   +1 more source

Biochemical characterization and DNA repair pathway interactions of Mag1-mediated base excision repair in Schizosaccharomyces pombe

, 2005
The Schizosaccharomyces pombe mag1 gene encodes a DNA repair enzyme with sequence similarity to the AlkA family of DNA glycosylases, which are essential for the removal of cytotoxic alkylation products, the premutagenic deamination product hypoxanthine ...
Alseth, I, Whitby, MC, Bjoras, M, Korvald, H, Tsaneva, I, Bjørås, M, Whitby, Matthew, Seeberg, E, Osman, F   +8 more
core   +1 more source

HIV-1 Vpr Reprograms CLR4^DCAF1 E3 Ubiquitin Ligase to Antagonize Exonuclease 1-Mediated Restriction of HIV-1 Infection

mBio, 2018
Viral accessory proteins hijack host cell E3 ubiquitin ligases to antagonize innate/intrinsic defenses and thereby provide a more permissive environment for virus replication.
Junpeng Yan, Ming-Chieh Shun, Caili Hao, Yi Zhang, Juan Qian, Kasia Hrecka, Maria DeLucia, Christina Monnie, Jinwoo Ahn, Jacek Skowronski   +9 more
doaj   +1 more source

Archaeal DNA Repair Mechanisms

Biomolecules, 2020
Archaea often thrive in environmental extremes, enduring levels of heat, pressure, salinity, pH, and radiation that prove intolerable to most life. Many environmental extremes raise the propensity for DNA damaging events and thus, impact DNA stability ...
Craig J. Marshall, Thomas J. Santangelo
doaj   +1 more source

Functional Characterization of Excision Repair and RecA-Dependent Recombinational DNA Repair in Campylobacter jejuni

, 2009
The presence and functionality of DNA repair mechanisms in Campylobacter jejuni are largely unknown. In silico analysis of the complete translated genome of C.
Dep Infectieziekten Immunologie, de Boer, A.G., Graaf-van Bloois, L., van der, Gaasbeek, E.J., Strategic Infection Biology, van Putten, J.P.M., van der Graaf-van Bloois, L., Boer, P., Wagenaar, J.A., Vermaning, B.J., van der Wal, F.J., Wal, F.J., van der, Putten, J.P.M., van, Boer, A.G., de   +13 more
core   +1 more source

GEN1 from a thermophilic fungus is functionally closely similar to non-eukaryotic junction-resolving enzymes [PDF]

, 2014
Processing of Holliday junctions is essential in recombination. We have identified the gene for the junction-resolving enzyme GEN1 from the thermophilic fungus Chaetomium thermophilum, and expressed the N-terminal 487 amino acid section. The protein is a
Lilley, David M.J., Lilley, David M. J., Déclais, Anne-Cécile; id_orcid, Freeman, Alasdair D.J., Lilley, David M. J.; id_orcid, Gartner, Anton, Déclais, Anne-Cécile, Liu, Yijin, Freeman, Alasdair D. J.   +8 more
core   +1 more source